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Use of an Isolated Perfused Kidney to Assess Renal Clearance of Drugs

Information Obtained in Steady-State and Non-Steady-State Experimental Systems

  • Chapter
Models for Assessing Drug Absorption and Metabolism

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 8))

Abstract

The kidney plays an important role in eliminating foreign compounds that enter the body as well as in regulating the body pool of endogenous substances. The appearance of drug in the urine is the net result of glomerular filtration, tubular secretion and reabsorption (Fig. 1).

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Author information

Authors and Affiliations

  1. Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama 222, Japan

    Noriko Okudaira

  2. Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan

    Yuichi Sugiyama

Authors
  1. Noriko Okudaira
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  2. Yuichi Sugiyama
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Editor information

Editors and Affiliations

  1. The University of Kansas, Lawrence, Kansas, USA

    Ronald T. Borchardt

  2. SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, USA

    Philip L. Smith

  3. Tacora Corporation, Seattle, Washington, USA

    Glynn Wilson

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© 1996 Springer Science+Business Media New York

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Okudaira, N., Sugiyama, Y. (1996). Use of an Isolated Perfused Kidney to Assess Renal Clearance of Drugs. In: Borchardt, R.T., Smith, P.L., Wilson, G. (eds) Models for Assessing Drug Absorption and Metabolism. Pharmaceutical Biotechnology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1863-5_12

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  • DOI: https://doi.org/10.1007/978-1-4899-1863-5_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1865-9

  • Online ISBN: 978-1-4899-1863-5

  • eBook Packages: Springer Book Archive

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