Abstract
Swine dysentery (SD) is a disease caused by an anaerobic spirochete, Serpulina hyodysenteriae and is characterized by a mucohemorrhagic diarrhea. Spirochetes isolated from the colon of pigs are identified on the basis of their hemolytic activity on blood agar with pathogenic Serpulina hyodysenteriae producing a complete hemolytic zone and nonpathogenic S. innocens producing an incomplete hemolysis. Recently, the hemolysin gene (tlyA) of S. hyodysenteriae which encodes for a 26–27 kDa protein has been cloned and expressed in E. coli (Muir et al., 1992) and hemolysin negative mutant strains of Serpulina hyodysenteriae have been produced (terHuune et al., 1992).
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© 1997 Springer Science+Business Media New York
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Hyatt, D.R., Joens, L.A. (1997). Functional Analysis of Serpulina Hyodysenteriae Hemolysin Lytic Activity. In: Paul, P.S., Francis, D.H., Benfield, D.A. (eds) Mechanisms in the Pathogenesis of Enteric Diseases. Advances in Experimental Medicine and Biology, vol 412. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1828-4_41
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DOI: https://doi.org/10.1007/978-1-4899-1828-4_41
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