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Neuro-Immune Pathobiology of Infectious Enteric Disease

  • Chapter
Mechanisms in the Pathogenesis of Enteric Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 412))

Summary

Recent knowledge of neuro-endocrine-immune communication in the intestinal mucosa has provided a new paradigm for the pathophysiology of diarrheal disease that will significantly alter and advance therapeutic strategies. Mast cells, enteroendocrine cells and phagocytes are the proximate mediators of signalling cascades activated by parasitic nematodes and food allergens, enterotoxigenic bacteria, and at least some of the invasive pathogens, respectively. These proximate, trigger cells give rise to products that affect epithelial function directly, or indirectly through stimulation of prostaglandin production by mesenchymal cells, and enteric nerve stimulation, which can markedly amplify the initial stimulus. The enteric nervous system in fact may mediate the majority of the secretory response induced by enterotoxins or phagocytes. The signalling network mediated by cells in the lamina propria provides new points of control for pharmacological therapy.

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Authors and Affiliations

  1. College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA

    Robert A. Argenzio

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  1. Robert A. Argenzio
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Editors and Affiliations

  1. Iowa State University, Ames, Iowa, USA

    Prem S. Paul

  2. South Dakota State University, Brookings, South Dakota, USA

    David H. Francis  & David A. Benfield  & 

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© 1997 Springer Science+Business Media New York

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Argenzio, R.A. (1997). Neuro-Immune Pathobiology of Infectious Enteric Disease. In: Paul, P.S., Francis, D.H., Benfield, D.A. (eds) Mechanisms in the Pathogenesis of Enteric Diseases. Advances in Experimental Medicine and Biology, vol 412. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1828-4_2

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  • DOI: https://doi.org/10.1007/978-1-4899-1828-4_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1830-7

  • Online ISBN: 978-1-4899-1828-4

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