Summary
Young chicks were experimentally infected with 6 strains of AEEC isolated from calves, pigs, chicks, and humans. AEEC colonized the cecum of chicks and induced the AE lesions on the mucosal surface. In the early stages of the AE lesions, AEEC attached to the enterocyte were enfolded with the microvilli. In the advanced stages, microvilli and cytoskeletons of the enterocytes were disrupted, and cytoplasmic cups and pedestal-like protrusions were formed on the cell surface. The AE lesions interconnected with the adjacent lesions, and it formed the network on the mucosal surface. Leukocytes infiltrated in the mucosa associated with AE lesions, and lymphatic nodules also developed. The results of these studies support the conclusion that chicks can be used as a model for the study of the lesions caused by AEEC.
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References
Sueyoshi, M., and Adachi, Y.,1990, Diarrhea induced by Treponema hyodysenteriae: a young chick cecal model for swine dysentery, Infect. Immun. 58: 3348–3362.
Sueyoshi, M., and Nakazawa, M., 1994, Experimental infection of young chicks with attaching and effacing Escherichia coli, Infect. Immun. 62: 4066–4071.
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© 1997 Springer Science+Business Media New York
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Sueyoshi, M., Nakazawa, M., Tanaka, S. (1997). A Chick Model for the Study of “Attaching and Effacing Escherichia coli” Infection. In: Paul, P.S., Francis, D.H., Benfield, D.A. (eds) Mechanisms in the Pathogenesis of Enteric Diseases. Advances in Experimental Medicine and Biology, vol 412. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1828-4_16
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DOI: https://doi.org/10.1007/978-1-4899-1828-4_16
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