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Comparison of Invasive (Septicemic) and Non Invasive Strains of Group A Streptococci Isolated During a One-Year National Survey in France

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Streptococci and the Host

Abstract

Delineation between invasive and non invasive strains of group A streptococci (Streptococcus pyogenes) is complex and important advances have been made in epidemiology and knowledge of the cofactors involved in pathogenicity, including the antigenically variant M protein.2,5 In previous series of pharyngitis and septicemic strains, we reported an association between biotypes and serotypes, which suggested that M proteins and physiological characters can cooperate for pathogenicity.1,3 This hypothesis led us to investigate a larger population of strains, responsible for invasive or non invasive infections, to determine whether invasiveness was associated with specific biotypes and serotypes.

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References

  1. Bouvet A., P. Geslin, P. Kriz-Kuzemenska, V. Blanc, C. Devine, and F. Grimont. 1994. Restricted association between biotypes and serotypes within group A streptococci. J. Clin. Microbiol. 32: 1312–1317.

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  2. Fischetti, V.A. 1989. Streptococcal M protein: molecular design and biological behavior. Clin. Microbiol. Rev. 2:285–314.

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  3. Geslin, P., P. Kriz-Kuzemenska, A. Frémaux, H. Havlickova, A. Dublanchet, and A. Bouvet. 1996. Septiceamia caused by phenotypic variants of group A streptococci. Res. Microbiol. 147: 273–277.

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  4. Johnson D.R., E.L. Kaplan, J. Sramek, R. Bicova, J. Havlicek, H. Havlickova, J. Motlova, and P. Kriz. 1996. Laboratory diagnosis of group A streptococcal infections. World Health Organization publications. Geneva, 1996.

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  5. Talkington, D.F., B. Schwartz, C.M. Black, J.K. Todd, J. Elliott, R.F. Breiman, and R.R. Facklam. 1993. Association of phenotypic and genotypic characteristics of invasive Streptococcus pyogenes isolates with clinical components of streptococcal toxic shock syndrome. Infect. Immun. 61: 3369–3374.

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© 1997 Springer Science+Business Media New York

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Varon, E. et al. (1997). Comparison of Invasive (Septicemic) and Non Invasive Strains of Group A Streptococci Isolated During a One-Year National Survey in France. In: Horaud, T., Bouvet, A., Leclercq, R., de Montclos, H., Sicard, M. (eds) Streptococci and the Host. Advances in Experimental Medicine and Biology, vol 418. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1825-3_21

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  • DOI: https://doi.org/10.1007/978-1-4899-1825-3_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1827-7

  • Online ISBN: 978-1-4899-1825-3

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