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Stimulation of Insulin Release In Vivo by the Methyl Esters of Succinic Acid and Glutamic Acid

  • Isabel Valverde
  • David Vicent
  • Marisa L. Villanueva-Peñacarrillo
  • Francine Malaisse-Lagae
  • Willy J. Malaisse
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 426)

Abstract

It is currently believed that, in non-insulin-dependent diabetes mellitus, the pancreatic islet B-cell suffers from a kind of blindness to D-glucose. The secretory response of the B-cell to the hexose indeed appears to be more severely affected than that evoked by other nutrient or non-nutrient secretagogues.

Keywords

Pancreatic Islet Succinic Acid Insulin Release Secretory Response Dimethyl Ester 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Isabel Valverde
    • 1
  • David Vicent
    • 1
  • Marisa L. Villanueva-Peñacarrillo
    • 1
  • Francine Malaisse-Lagae
    • 2
  • Willy J. Malaisse
    • 2
  1. 1.Fundacion Jimenez DiazMadridSpain
  2. 2.Laboratory of Experimental MedicineBrussels Free UniversityBrusselsBelgium

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