Effects of Localized Pulses of High K+ and Carbachol on [Ca2+]i in Pancreatic Islets of Langerhans

  • Ana Gomis
  • Miguel Valdeolmillos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 426)


Pancreatic β-cells, naturally exist aggregated forming the islet of Langerhans. Isolated β-cells show a marked variability in their response to secretagogues. The variability is found for instance in their electrical response to glucose1, changes in intracellular calcium ([Ca2+]i)2 and insulin release3–4. Such variability contrast with the homogeneous response of the islet of Langerhans, at least with regard to glucose-induced electrical activity5 and [Ca2+]i oscillations6.


Pancreatic Islet Electrical Coupling Patch Pipette Mouse Islet Junctional Coupling 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Ana Gomis
    • 1
  • Miguel Valdeolmillos
    • 1
  1. 1.Departamento de Fisiología and Instituto de Neurociencias, Facultad de MedicinaUniversidad Miguel HernandezAlicanteSpain

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