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Effects of Localized Pulses of High K+ and Carbachol on [Ca2+]i in Pancreatic Islets of Langerhans

  • Ana Gomis
  • Miguel Valdeolmillos
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  • 116 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 426)

Abstract

Pancreatic β-cells, naturally exist aggregated forming the islet of Langerhans. Isolated β-cells show a marked variability in their response to secretagogues. The variability is found for instance in their electrical response to glucose1, changes in intracellular calcium ([Ca2+]i)2 and insulin release3–4. Such variability contrast with the homogeneous response of the islet of Langerhans, at least with regard to glucose-induced electrical activity5 and [Ca2+]i oscillations6.

Keywords

Pancreatic Islet Electrical Coupling Patch Pipette Mouse Islet Junctional Coupling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Ana Gomis
    • 1
  • Miguel Valdeolmillos
    • 1
  1. 1.Departamento de Fisiología and Instituto de Neurociencias, Facultad de MedicinaUniversidad Miguel HernandezAlicanteSpain

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