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Glyceraldehyde and the Pancreatic β-Cell

  • L. Best
  • A. C. Elliott
  • J. Davies
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 426)

Abstract

D-glyceraldehyde is commonly used as a stimulus of insulin release from the pancreatic β-cell1–3. It is generally accepted that the triose can be metabolized in the β-cell via the glycolytic pathway, thus stimulating insulin release in a manner analogous to glucose1–3. In numerous studies of tumoural β-cell lines which, owing to abnormalities in glucose transport or metabolism, fail to respond to the sugar, glyceraldehyde has been employed as a ‘nutrient’ type stimulus4–6. The results of our studies on glyceraldehyde actions on the HIT-T15 cell line suggest, however, that the triose is poorly metabolized in these cells and that, unlike glucose, it stimulates the β-cell by a mechanism which does not involve its glycolytic metabolism.

Keywords

Insulin Release Methyl Glyoxal Intracellular Acidification Glycolytic Metabolism Insulinoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • L. Best
    • 1
  • A. C. Elliott
    • 1
  • J. Davies
    • 1
  1. 1.Departments of Medicine and Physiological SciencesUniversity of ManchesterManchesterUK

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