Reciprocal Links Between Metabolic and Ionic Events in Islet Cells

Their Relevance to the Rhythmics of Insulin Release
  • Willy J. Malaisse
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 426)


It has long been known that insulin release may occur according to a rhythmic pattern at least from the isolated perfused pancreas.1 Likewise, it has long been questioned whether oscillations of metabolic events take place in glucose-stimulated islets and might account for the rhythmic pattern of insulin release.2,3 The present review refers to selected observations which are considered relevant to these issues.


Islet Cell Insulin Release Ionic Event Rhythmic Pattern Muscle Extract 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Willy J. Malaisse
    • 1
  1. 1.Laboratory of Experimental MedicineBrussels Free UniversityBrusselsBelgium

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