Reciprocal Links Between Metabolic and Ionic Events in Islet Cells
- 117 Downloads
It has long been known that insulin release may occur according to a rhythmic pattern at least from the isolated perfused pancreas.1 Likewise, it has long been questioned whether oscillations of metabolic events take place in glucose-stimulated islets and might account for the rhythmic pattern of insulin release.2,3 The present review refers to selected observations which are considered relevant to these issues.
KeywordsIslet Cell Insulin Release Ionic Event Rhythmic Pattern Muscle Extract
Unable to display preview. Download preview PDF.
- 3.W.J. Malaisse, A. Sener, A. Herchuelz, I. Valverde, J.C. Hutton, I. Atwater and V. Leclercq-Meyer, The interplay between metabolic and cationic events in islet cells: coupling factors and feedback mechanisms. Horm. Metab. Res. suppl. 10:61–66 (1980).Google Scholar
- 4.V. Leclercq-Meyer and W.J. Malaisse, Pulsatility of arginine-stimulated insulin, glucagon and somatostatin release, Med Sci. Res. 22:151–154 (1994).Google Scholar
- 6.M. Deleers, M. Mahy and W.J. Malaisse, Glucose increases cytosolic Ca2+ activity in pancreatic islet cells, Biochem. Internat. 10:97–103 (1985).Google Scholar
- 9.G. Bernardy, A. Sener and W.J. Malaisse, Absence of glycolytic oscillation in rat liver extracts, Med. Sci. Res. 22:155–157 (1994).Google Scholar