Abstract
Pancreatic insulin secretion is under control by peptides, as well as by nutrients and other substances(1,2). Truncated glucagon like peptide-1 (tGLP-1), gastric inhibitory peptide (GIP) and glucagon, the members of glucagon/VIP/secretin family of peptides, stimulate insulin release in a low concentration range around 10−9 M, and are thought to be involved in the physiological regulation of insulin release(3–5).
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Yada, T., Sakurada, M., Nakata, M., Yaekura, K., Kikuchi, M. (1997). PACAP as Low as 10−13 M Raises Cytosolic Ca2+ Activity in Pancreatic B-Cells by Augmenting Ca2+ Influx Through L-Type Ca2+ Channels to Trigger Insulin Release. In: Soria, B. (eds) Physiology and Pathophysiology of the Islets of Langerhans. Advances in Experimental Medicine and Biology, vol 426. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1819-2_22
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DOI: https://doi.org/10.1007/978-1-4899-1819-2_22
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