Pyridothiadiazines as Potent Inhibitors of Glucose-Induced Insulin Release
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In the last few years, great interest has been focused on drugs (diazoxide, pinacidil, cromakalim,...) whose mechanism of action involves the activation of membrane K+ channels (1,2). Such compounds, which may control the membrane potential and the excitability of a variety of cells, constitute a new class of drugs: the “K+ channel openers.” Although the K+ channel openers presently available display several potential clinical applications, the diversity of K+ channels offers the possibility to develop new agents selective for specific K+ channel types.
KeywordsChannel Opener Insulin Release Sodium Nitroprusside Extracellular Concentration Channel Type
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