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Pyridothiadiazines as Potent Inhibitors of Glucose-Induced Insulin Release

  • P. Lebrun
  • M.-H. Antoine
  • R. Ouedraogo
  • A. Herchuelz
  • P. de Tullio
  • J. Delarge
  • B. Pirotte
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 426)

Abstract

In the last few years, great interest has been focused on drugs (diazoxide, pinacidil, cromakalim,...) whose mechanism of action involves the activation of membrane K+ channels (1,2). Such compounds, which may control the membrane potential and the excitability of a variety of cells, constitute a new class of drugs: the “K+ channel openers.” Although the K+ channel openers presently available display several potential clinical applications, the diversity of K+ channels offers the possibility to develop new agents selective for specific K+ channel types.

Keywords

Channel Opener Insulin Release Sodium Nitroprusside Extracellular Concentration Channel Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    P. Lebrun, M.-H. Antoine and A. Herchuelz, Minireview: K+ channel openers and insulin release, Life Sciences 51:795 (1992).PubMedCrossRefGoogle Scholar
  2. 2.
    N.S. Cook and U. Quast, Potassium channel pharmacology, in: “Potassium channels, Structure, Classification, Function and Therapeutic potential”, N.S. Cook, ed, Ellis Horwood Limited, Chichester, England (1990).Google Scholar
  3. 3.
    B. Pirotte, P. de Tullio, P. Lebrun, M.-H. Antoine, B. Masereel, M. Schynts, L. Dupont, A. Herchuelz and J. Delarge, 3-Alkylamino-4H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from pancreatic B cells, J. Med. Chem. 36:3211 (1993).PubMedCrossRefGoogle Scholar
  4. 4.
    P. Lebrun, V. Devreux, M. Hermann and A. Herchuelz, Similarities between the effects of pinacidil and diazoxide on ionic and secretory events in rat pancreatic islets, J. Pharmacol. Exp. Ther. 250:1011 (1989).PubMedGoogle Scholar
  5. 5.
    M.-H. Antoine, M. Hermann, A. Herchuelz and P. Lebrun, Sodium nitroprusside inhibits glucose-induced insulin release by activating ATP-sensitive K+ channels, Biochim. Biophys. Acta 1175:293 (1993).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • P. Lebrun
    • 1
  • M.-H. Antoine
    • 1
  • R. Ouedraogo
    • 1
  • A. Herchuelz
    • 1
  • P. de Tullio
    • 2
  • J. Delarge
    • 2
  • B. Pirotte
    • 2
  1. 1.Laboratory of Pharmacology, School of MedicineFree University of BrusselsBrusselsBelgium
  2. 2.Department of Medicinal ChemistryUniversity of LiègeLiègeBelgium

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