Islet Release of ACTH-Like Peptides and their Modulatory Effect on Insulin Secretion

  • Juan J. Gagliardino
  • María I. Borelli
  • Fernando Estivariz
  • Illani Atwater
  • Carlos Boschero
  • Eduardo Rojas
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 426)


The B-cell secretion of insulin in response to glucose is modulated by different hormones1,5. Some of these hormones are produced by non-B islet cells and also by the B-cells themselves. Among these hormones, the presence of POMC6 and some of its derivative products such as endorphin7,8, ACTH9 and corticotropin-like intermediate peptide10 has been identified in the islets. It has not yet been established whether the endogenous islet POMC and its derivatives play any modulatory role in the secretion of insulin. On the other hand, it has already been reported that ACTH enhances the secretion of insulin in response to glucose11,12. Such effect has been attributed to its stimulation on islet adenylate cyclase13 and to the consequent increase of 3′5′-cAMP14 in islet content, but the mechanism by which ACTH stimulates the release of insulin is not clear.


Insulin Secretion ATPase Activity Insulin Release Krebs Ringer Bicarbonate Buffer Islet Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Juan J. Gagliardino
    • 1
  • María I. Borelli
    • 1
  • Fernando Estivariz
    • 1
  • Illani Atwater
    • 2
  • Carlos Boschero
    • 2
  • Eduardo Rojas
    • 2
  1. 1.CENEXA-Centro de Endocrinología Experimental y Aplicada (UNLP-CONICET)La PlataArgentina
  2. 2.Laboratory of Cell Biology and Genetics, NIDDKNational Institutes of HealthBethesdaUSA

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