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The Human Glucagon-Like Peptide-1 (GLP-1) Receptor

Cloning and Functional Expression
  • Joseph S. Dillon
  • Michael B. Wheeler
  • Xing-Hong Leng
  • B. Brooke Ligon
  • Aubrey E. BoydIII
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 426)

Abstract

At similar plasma glucose concentrations much greater insulin secretion is achieved with oral glucose than with intravenous glucose. These observations lead to the concept that gastrointestinal factors (incretins) are released by nutrients, particularly glucose, to potentiate insulin release (Creutzfeldt, 1979). The two most potent incretins, GLP-1(7–37) and its amidated form GLP-1(7–36 amide), are processed from the parent 37 amino acid GLP-1 peptide, which is produced in intestinal L-cells as a posttranslational product of preproglucagon.

Keywords

Adenylyl Cyclase Human Receptor Human Pancreatic Islet Increase cAMP Level Adenylyl Cyclase System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Creutzfeldt, W. (1979). The incretin concept today. Diabetologia, 16, 75–85.PubMedCrossRefGoogle Scholar
  2. Gutniak, M., Orskov, C., Holst, J. J., Ahren, B. and Efendic, S. (1992). Antidiabetogenic effect of glucagon-like peptide-1(7–36)amide in normal subjects and patients with diabetes mellitus. New England Journal of Medicine, 326(20), 1316–22.PubMedCrossRefGoogle Scholar
  3. Holz, G. A., Kuhtreiber, W. M. and Habener, J. F. (1993). Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7–37). Nature, 361(6410), 362–5.PubMedCrossRefGoogle Scholar
  4. Lu, M. (1993) Signal transduction of the endogenous and recombinant glucagon-like peptide 1(7–37) receptor. PhD Thesis in Cell Biology, Baylor College of Medicine.Google Scholar
  5. Rajan, A., Hill, R. and Boyd, A. (1989). Effect of rise in cAMP levels on Ca2+ influx through voltage dependent Ca2+ channels in HIT cells. Diabetes, 38, 874–880.PubMedCrossRefGoogle Scholar
  6. Thorens, B. (1992). Expression cloning of the pancreatic β cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proceedings of the National Academy of Sciences USA., 89(September), 8641–8645.CrossRefGoogle Scholar
  7. Wheeler, M., Lu, M., Dillon, J., Leng, X.-H., Chen, C. and Boyd, A. (1993). Functional expression of the glucagon-like peptide-1(7–37) receptor: evidence for coupling to phospholipase C as well as adenylyl cyclase. Endocrinology, 133, 57–62.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Joseph S. Dillon
    • 1
  • Michael B. Wheeler
    • 1
  • Xing-Hong Leng
    • 1
  • B. Brooke Ligon
    • 1
  • Aubrey E. BoydIII
    • 1
  1. 1.Division of Endocrinology, Diabetes, Metabolism and Molecular Medicine New England Medical CenterTufts University School of MedicineBostonUSA

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