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Calcyclin, a Calcium-Binding Protein, which Regulates Insulin Secretion from the Permeabilized Pancreatic β-Cell

  • Ichiro Niki
  • Katsuo Okazaki
  • Satoshi Iino
  • Sigeru Kobayashi
  • Hiroyoshi Hidaka
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 426)

Abstract

Although it is widely accepted that an increase in intracellular Ca2+ is a crucial event in the stimulus-secretion coupling in the pancreatic β-cell [1], we have limited knowledge on the later steps in the signal transduction pathway. Calcium binding proteins are considered to be involved in the control of Ca2+-dependent cellular functions including hormone release [2]. Various types of calcium-binding proteins such as calmodulin, calbindin and S-100b protein are identified in the islet cells biochemically or immunohistochemically [3,4]. Calmodulin, the best characterized calcium binding protein, was demonstrated to exist in the pancreatic islet cells by Sugden et al [5]. The pancreatic β-cell possesses the kinase activity which is dependent on Ca2+/calmodulin [6]. Involvement of calmodulin and calmodulin-dependent protein kinases in insulin release has been suggested mainly based on the inhibitory effect of calmodulin antagonists on the release [7,8,9], albeit there is the argument against this idea [10].

Keywords

Pancreatic Islet Insulin Release Calcium Binding Protein Pancreatic Islet Cell Rabbit Lung 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Ichiro Niki
    • 1
  • Katsuo Okazaki
    • 1
  • Satoshi Iino
    • 1
  • Sigeru Kobayashi
    • 1
  • Hiroyoshi Hidaka
    • 1
  1. 1.Departments of Pharmacology and AnatomyNagoya University School of MedicineShowa-ku, 466, NagoyaJapan

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