Immunological Analysis of G-Protein Expression in the Endocrine Pancreas
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Inhibition of insulin secretion by agonists acting at cell surface receptors (e.g. α2-agonists, somatostatin, galanin) is mediated by one or more guanine-nucleotide binding (G) proteins that serve as substrates for pertussis toxin1. Recent work has established that a family of such proteins exist and that at least 3 subtypes (Gi2 and two forms of Go) are present in rat islet cells2,3.
KeywordsInsulin Secretion Pertussis Toxin RINm5F Cell Galanin Receptor Normal Islet
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- 7.A. Schmidt, J. Hescheler, S. Offermanns, K. Spicher, K-D. Hinsch, F-J. Klinz, J. Codina, L. Birnbaumer, H. Gausepoh, R. Frank, G. Schultz and W. Rosenthal, Involvement of pertussis toxin sensitive G-proteins in the hormonal inhibition of dihydropyridine sensitive Ca currents in an insulin secreting cell line (RINm5F), J. Biol. Chem. 266:18025 (1991).PubMedGoogle Scholar