Abstract
Platelet-activating factor (PAF) is not only a potent proinflammatory compound, but also plays important roles in reproductive, gastrointestinal, neuronal, respiratory systems (Hanahan, 1986; Barnes et al., 1988; Prescott et al., 1990; Bazan, 1994; Snyder, 1995; Izumi and Shimizu, 1995). These diverse actions might be through a PAF receptor expressed in the plasma membrane (Shimizu et al., 1992; Chao and Olson, 1993). The cloned receptor is a member of G-protein-coupled receptor superfamily (Figure 1).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Barnes, P.J., Chung, K.F., and Page, C.P. (1988) J. Allergy Clin. Immunol. 81: 919–934
Bazan, N.G. (1994) J. Lipid Mediators Cell Signal. 10: 83–86
Bito, H., Honda, Z., Nakamura, M., and Shimizu, T. (1994) Eur. J. Biochem. 221: 211–218
Chao, W., and Olson, M.S. (1993) Biochem. J. 292: 617–629.
Ferby, I.M., Waga, I., Sakanaka, C., Kume, K., and Shimizu, T. (1994) J. Biol. Chem. 269: 30485–30488.
Ferby, I.M., Waga, I., Hoshino, M., Kume, K., and Shimizu, T. (1996) J. Biol. Chem. 271: in press
Hanahan, D.J. (1986) Annu. Rev. Biochem. 55: 483–509
Honda, Z., Nakamura, M., Miki, I., Minami, M., Watanabe, T., Seyama, Y., Okado, H., Toh, H., Ito, K., Miyamaoto, T., and Shimizu, T. (1991) Nature 349: 342–346
Honda, Z., Takano, T., Gotoh, Y., Nishida, E., Ito, K., and Shimizu, T. (1994) J. Biol. Chem. 269: 2307–2315
Ishii, S., Matsuda, Y., Nakamura, M., Waga, I., Kume, K., Izumi, T., and Shimizu, T. (1996) Biochem. J. 314: 671–678
Ishii, S., Nagase, T., Tashiro, F., Ikuta, K., Sato, S., Waga, I., Kume, K., Miyazaki, J., and Shimizu, T. (1997) EMBO J. 16: 133–142.
Izumi, T., Kishimoto, S., Takano, T., Nakamura, M., Miyabe, Y., Nakata, M., Sakanaka, C., and Shimizu, T. (1995) Biochem. J. 305: 829–4835
Izumi, T., and Shimizu, T. (1995) Biochim. Biophys. Acta 1259: 317–333
Kunz, D., Gerard, N.P., and Gerard, C. (1992) J. Biol. Chem. 267: 9101–9106.
Liu, H., Chao, W., and Olson, M.S. (1992) J. Biol. Chem. 267: 20811–20819
Liu, B., Nakashima, S., Kanoh, H., Takano, T., Shimizu, T., and Nozawa, Y. (1994) J. Biochem. 116: 882–891
Mori, M., Aihara, M., Kume, K., Hamanoue, M., Kohsaka, S., and Shimizu, T. (1996). J. Neurosci., in press
Mutoh, H., Bito, H., Minami, M., Nakamura, M., Honda, Z., Izumi, T., Nakata, R., Kurachi, Y., Terano, A., and Shimizu, T. (1993) FEBS Lett. 322: 129–134
Mutoh, H., Kume, K., Sato, S., Kato, S., and Shimizu, T. (1994a) Biochem. Biophys. Res. Commun. 205: 1130–1136
Mutoh, H., Ishii, S., Izumi, T., Kato, S., and Shimizu, T. (1994b) Biochem. Biophys. Res. Commun. 205: 1137–1142
Mutoh, H., Fukuda, T., Kitamoto, T., Masushige, S., Sasaki, H., Shimizu, T., and Kato, S. (1996) Proc. Natl. Acad. Sci. USA 93: 774–779
Nakamura, M., Honda, Z., Izumi, T., Sakanaka, C., Mutoh, H., Minami, M., Bito, H., Seyama, Y., Matsumoto, T, Noma, M., and Shimizu, T. (1991) J. Biol. Chem. 266: 20400–20405
Pang, J-H.S., Hung, R-Y, Wu, C-J., Fang, Y-Y., and Chau, L-Y (1995) J. Biol. Chem. 270: 14123–14129
Prescott, S.M., Zimmerman, G.A., and Mclntyre, T.M. (1990). J. Biol. Chem. 265: 17381–17384
Sato, S., Kume, K., Taketani, Y., and Shimizu, T. J. Lipid Mediators Cell Signal. (in press)
Shimizu, T., Honda, Z., Nakamura, M., Bito, H., and Izumi, T. (1992) Biochem. Pharmacol. 44: 1001–1008
Shukla, S.D. (1992) FASEB J. 6: 2296–2301
Snyder, F. (1995) Biochem. J. 305: 689–705
Strahle, U., Schmidt, M.C., Kelsey, G., Stewart, A.F., Cole, T.J., Schmid, W., and Schutz, G. (1992) Proc. Natl. Acad. Sci. USA 89: 6731–6735
Sugimoto, T., Tsuchimochi, H., McGregor, CG., Mutoh, H., Shimizu, T., and Kurachi, Y (1992) Biochem. Biophys. Res. Commun. 189: 617–624
Takano, T., Honda, Z., Sakanaka, C., Izumi, T., Kameyama, K., Haga, K., Haga, T., Kurokawa, K., and Shimizu, T. (1994) J. Biol. Chem. 269: 22453–22458
Ye, R.D., Prossnitzu, E.R., Zou, A.H., and Cochrane, C.G. (1991) Biochem. Biophys. Res. Commun. 180: 105–111
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Shimizu, T., Mutoh, H. (1997). Structure and Regulation of Platelet Activating Factor Receptor Gene. In: Honn, K.V., Marnett, L.J., Nigam, S., Jones, R.L., Wong, P.YK. (eds) Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3. Advances in Experimental Medicine and Biology, vol 407. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1813-0_30
Download citation
DOI: https://doi.org/10.1007/978-1-4899-1813-0_30
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-1815-4
Online ISBN: 978-1-4899-1813-0
eBook Packages: Springer Book Archive