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Characterization and Molecular Cloning of Mouse Type II Phospholipase A2

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Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 407))

Abstract

Phospholipase A2 (PLA2) plays a crucial role in diverse cellular responses including phospholipid digestion and metabolism, host defence, and signal transduction. PLA2 also provides precursors for eicosanoid generation when the cleaved fatty acid is arachidonic acid, or platelet-activating factor (PAF) formation when the sn-1 position of the phosphatidylcholine (PC) contains an alkyl ether linkage. Recent advances in molecular and cellular biology have enabled us to understand the molecular nature, possible function and regulation of each PLA2 isozyme. Mammalian tissues and cells generally contain more than one enzyme, each of which is regulated independently and has distinct functions. Thus, cytosolic PLA2 (cPLA2) and two types of secretory PLA2s (type I and type II) are the best characterized members of a still expanding large family of mammalian PLA2 s1,2.

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Author information

Authors and Affiliations

  1. School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142, Japan

    Noriko Hara, Makoto Murakami, Yoshihito Nakatani & Ichiro Kudo

  2. Faculty of Pharmaceutical Sciences, The University of Tokyo, 3-7-1 Hongo, Bunkyo-ku, Tokyo 113, Japan

    Noriko Hara & Keizo Inoue

Authors
  1. Noriko Hara
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  2. Makoto Murakami
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  3. Yoshihito Nakatani
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  4. Keizo Inoue
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  5. Ichiro Kudo
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Editor information

Editors and Affiliations

  1. Wayne State University, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Vanderbilt University, Nashville, Tennessee, USA

    Lawrence J. Marnett

  3. Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

    Robert L. Jones

  5. University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, USA

    Patrick Y.-K. Wong

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© 1997 Springer Science+Business Media New York

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Hara, N., Murakami, M., Nakatani, Y., Inoue, K., Kudo, I. (1997). Characterization and Molecular Cloning of Mouse Type II Phospholipase A2 . In: Honn, K.V., Marnett, L.J., Nigam, S., Jones, R.L., Wong, P.YK. (eds) Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3. Advances in Experimental Medicine and Biology, vol 407. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1813-0_17

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  • DOI: https://doi.org/10.1007/978-1-4899-1813-0_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1815-4

  • Online ISBN: 978-1-4899-1813-0

  • eBook Packages: Springer Book Archive

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