Abstract
Dipodascopsis uninucleata, a lipomycetaceous mycelial yeast with a well-defined life cycle, synthesises small amounts of arachidonic acid (ARA) and also produces the novel pharmacologically active metabolite, 3-hydroxyarachidonic acid (3-hydroxyeicosatetraenoic acid, 3-HETE) from exogenous ARA during its sexual phase (van Dyk et al, 1991; Kock et al, 1997). The production of 3-HETE from exogenous ARA and both ascosporogenesis and ascospore production in D. uninucleata were all inhibited by 1 mM aspirin (van Dyk et al, 1991; Botha et al, 1992; Coetzee et al, 1992).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Botha A, Kock, JLF, Coetzee DJ, Linde NA & van Dyk MS (1992) The influence of NSAIDs on the life cycle of Dipodascopsis uninucleata. System Appi Microbiol, 15: 155–160
Brodowsky ID & Oliw EH (1992) Metabolism of 18: 2, 18: 3, 20: 4 and 20: 5 by the fungus Gaeumannomyces graminis. Biochim Biophys Acta, 1124, 59–65
Brodowsky ID, Hamberg M & Oliw EH (1992) A linoleic (8R) dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. J Biol Chem, 267: 14738–14745
Coetzee DJ, Kock JLF, Botha A, van Dyk MS, Smit EJ, Botes PJ & Augustyn OPH (1992) Yeast Eicosanoids III. The distribution of arachidonic acid metabolites in the life-cycle of Dipodascopsis uninucleata. System Appl Microbiol, 15: 311–318
Elliot WJ, Morrison AR, Sprecher H & Needleman P (1986) Calcium-dependent oxidation of 5,8,11-icosatrienoic acid by the cyclooxygenase enzyme system. J Biol Chem, 261: 6719–6724
Ellis JS, Keenan PJ, Rathmell WG & Friend J (1993) Inhibition of phytoalexin accumulation in potato tuber discs by Superoxide scavengers. Phytochemistry, 34: 649–655
Fox SR, Ratledge C & Friend J (1997) Optimisation of 3-hydroxyeicosanoid biosynthesis by the yeast Dipodascopsis uninucleata. Biotechnology Letters, 19, 155–158
Hamberg, M (1986) Isolation and structures of lipoxygenase products from Saprolegnia parasitica. Biochim Biophys Acta, 876: 688–692
Hamberg M, Herman CA & Herman P (1986) Novel biological transformations of 15-L-hydroperoxy-5,8,11,13-eicosatetraenoic acid. Biochim Biophys Acta, 877: 447–457
Hiltunen JK, Wenzel B, Beyer A, Erdmann R, Fossa A & Kunau W-H (1992) Peroxisomal multifunctional β-oxidation protein of Saccharomyces cerevisiae. J Biol Chem, 267: 6646–6653
Jin S-J, Hoppel CL & Tserng K-Y (1992) Incomplete fatty oxidation-the production and epimerisation of 3-hydroxy fatty acids. J Biol Chem, 267: 119–125
Kock JLF, van Vuuren J, Botha A, van Dyk MS, Coetzee DJ, Botes PJ, Shaw N, Friend J, Ratledge C, Roberts AD & Nigam S (1997) The production of biologically active 3-HETE and linoleic acid metabolites by Dipodascopsis. System Appl Microbiol, 20: 39–49.
Luthria DL, Baykousheva SP & Sprecher H (1995) Double bond removal from odd-numbered carbons during peroxisomal β-oxidation of arachidonic acid. J Biol Chem, 270: 13771–13778
Sircar JC, Schwender CF & Johnson EA (1983) Soybean lipoxygenase inhibition by nonsteroidal antiinflammatory drugs. Prostaglandins, 25: 393–396
van Dyk MS, Kock JLF, Coetzee DJ, Augustyn OPH & Nigam S (1991) Isolation of a new aspirin-sensitive arachidonic acid metabolite 3-HETE from the yeast Dipodascopsis uninucleata. FEBS Lett, 283: 195–198
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Akpinar, A., Fox, S.R., Ratledge, C., Friend, J. (1997). Biotransformation of Arachidonic Acid and Other Eicosanoids by the Yeast Dipodascopsis uninucleata, the Oomycete Fungi Saprolegnia diclina and Leptomitus lacteus and the Zygomycete Fungus Mortierella isabellina . In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_49
Download citation
DOI: https://doi.org/10.1007/978-1-4899-1810-9_49
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-1812-3
Online ISBN: 978-1-4899-1810-9
eBook Packages: Springer Book Archive