Abstract
Eicosanoid precursors for commercial utilization are currently obtained predominantly from animal sources (Ratledge, 1994). However, the mucoralean fungi turned out to be an alternative source (Shimizu and Yamada, 1989; Ratledge, 1994). These fungi are more suitable for the production of large quantities of eicosanoid precursors, such as arachidonic acid [20: 4(ω6)], dihomo-gamma-linolenic acid [20: 3(ω6)], eicosapentaenoic acid [20: 5(ω3)] and gamma-linolenic acid [18: 3(ω6)]. In order to develop commercial biotechnological processes, it is necessary that favourable fungal strains are selected and that these are screened for the production of eicosanoid precursors from more affordable substrates. The present study reviews the pivotal role of mucoralean fungi in the production of eicosanoid precursors.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Alexander, M., 1961, Fungi, in: Introduction to Soil Microbiology, M. Alexander, ed., John Wiley and sons, Inc. New York.
Bajpai, P., and Bajpai, P.K., 1993, Eicosapentaenoic acid (EPA) production from microorganisms: a review, J. Biotechnol. 30: 161.
Bartshi, C., Berthier, J., Guiguettaz, C., and Valla, G., 1991, A selective medium for the isolation and enumeration of Mucor species, Mycol. Res. 95: 373.
Botha, A., Kock, J.L.F., Roux, G, Coetzee, D.J., and Botes, P.J., 1995, An isolation medium for gamma-linolenic acid producing mucoralean fungi, System. Appl. Microbiol. 18: 448.
Du Preez, J.C., Immelman, M., Kock, J.L.F., and Killian, S.G., 1995, Production of gamma-linolenic acid by Mucor circinelloides and Mucor rouxii with acetic acid as carbon substrate, Biotechnol. Lett. 17: 933.
Du Preez, J.C., Immelman, M., Kock, J.L.F,. and Killian, S.G., 1997, The effect of acetic acid concentration on the growth and production of gamma-linolenic acid by Mucor circinelloides CBS203.28 in fed-batch culture, World J. Microbiol. Biotechnol. 13: 81.
Eicker, A., 1974. The mycoflora of an alkaline soil of the Open-Savannah of the Transvaal, Trans. Brit. Mycol. Soc. 63: 281.
Embree, R.W., 1963, Observations on Mortierella vesiculosa, Trans. Brit. Mycol. Soc. 46: 560.
Hansson, L., and Dostalek, M., 1988, Effect of culture conditions on mycelial growth and production of gamma-linolenic acid by the fungus Mortierella ramanniana, Appl. Microbiol. Biotechnol. 28: 240.
Hesseltine, C.W., and Ellis, J.J., 1973, Chapter 11, Mucorales, in: The Fungi, an Advanced Treatise vol. 4B, G.C. Ainsworth, F.K. Sparrow and A.S. Sussman, eds., Academic Press, London.
Jeffery, J., Kock, J.L.F., Botha, A., Coetzee, D.J., Botes, P.J., and Nigam, S., 1997, Enhanced sunflower oil utilisation and gamma-linolenic acid production by Mucor circinelloides f. circinelloides CBS 108.16 in the presence of acetate, World J. Microbiol. Biotechnol. (Accepted for publication).
Kock, J.L.F., and Botha, A., 1993, Acetic acid-a novel source for the production of gamma-linolenic acid and cocoa butter equivalents, S.Afr. J. Sci. 89: 465.
Kock, J.L.F., and Botha, A., 1995, Biological treatment and cultivation of microorganisms, United States Patent No. 5,429,942.
Kock, J.L.F., Coetzee, D.J., Van Dyk, M.S., Truscott, M., Cloete, F.G., Van Wyk, V., and Augustyn, O.P.H., 1991, Evidence for pharmacologically active prostaglandins in yeasts, S.Afr. J. Sci. 87: 73.
Ratledge, C., 1991, Microorganisms for lipids, Acta Biotechnol. 11: 429.
Ratledge, C., 1994, Yeasts, molds, algae and bacteria as sources of lipids, in: Technological Advances in Improved and Alternative Sources of Lipids, B.S. Kamel and Y. Kakuda, eds., Blackie academic and professional, London.
Sajbidor, J., Dobronova, S., and Certik, M., 1990, Arachidonic acid production by Mortierella sp. S-17, influence of C/N ratio, Biotechnol. Lett. 12: 455.
Shimizu, S., and Yamada, H., 1989, Microbial production of polyunsaturated fatty acids (vitamin-F group), in: Biotechnology of Vitamins, Pigments and Growth Factors, E.J. Vandamme, ed., Elsevier Applied Science, London.
Steiman, R., Guiraud, P., Sage, L., Seigle-Murandi, F., and Lafond, J-L., 1995, Mycoflora of soil around the Dead Sea, I-Ascomycetes (including Aspergillus and Penicillium), Basidiomycetes, Zygomycetes, System. Appl. Microbiol. 18: 310.
Tsuchiura, O.S., and Sakura, T.Y., 1988, Method for the preparation of a fungal body and a lipid rich in gamma-linolenic acid therefrom, United States Patent No. 4,783,408.
Van Dyk, M.S., Kock, J.L.F., Coetzee, D.J., Augustyn, O.P.H., and Nigam, S., 1991, Isolation of a novel arachidonic acid metabolite 3-hydroxy 5,8,11 J4-eicosatetraenoic acid (3-HETE) from the yeast Dipodascopsis uninucleata UOFS-Y128, FEBS Lett. 283: 195.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Botha, A., Kock, J.L.F., Nigam, S. (1997). The Production of Eicosanoid Precursors by Mucoralean Fungi. In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_48
Download citation
DOI: https://doi.org/10.1007/978-1-4899-1810-9_48
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-1812-3
Online ISBN: 978-1-4899-1810-9
eBook Packages: Springer Book Archive