Abstract
In recent years several studies have examined whether eicosanoids might facilitate neurotransmission in pain pathways. Discrepancies between the doses of some non-steroidal antiinflammatory drugs (NSAIDs) required to produce antiinflammatory and analgesic effects suggest that the analgesic actions may arise through a central action of NSAIDs (McCormack and Urquart, 1995). Evidence supporting this hypothesis has come from behavioural experiments which have shown that intrathecally applied NSAIDs reduce pain-related behaviour in the rat formalin model of inflammation (Malmberg and Yaksh, 1992). Furthermore, NSAIDs applied intravenously reduce the responses of rat spinal cord neurones, rendered hyperexcitable by an acute arthritic lesion, to innocuous and noxious stimuli applied to the inflamed knee (Neugebauer et al., 1995).
Keywords
- Dorsal Horn
- Spinal Cord Neurone
- Superficial Dorsal Horn
- Spinal Dorsal Horn Neurone
- United Kingdom Introduction
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Chapman, V. and Dickenson, A.H., 1992, The spinal and peripheral roles of bradykinin and prostaglandins in nociceptive processing in the rat. Eur. J. Pharmacol. 219: 427–433.
Grubb, B.D., Stiller, R.U. and Schaible, H.-G., 1993, Dynamic changes in the receptive field properties of spinal cord neurones with ankle input in rats with chronic unilateral inflammation in the ankle region. Exp. Brain Res. 92: 441–452.
McCormack, K. and Urquart, E., 1995, Correlation between non-steroidal anti-inflammatory drug efficacy in a clinical pain model and the dissociation of their anti-inflammatory and analgesic properties in animal models. Clin. Drug Invest. 9: 88–97.
Malmberg, A.B. and Yaksh, T.L., 1992, Antinociceptive actions of spinal non-steroidal anti-inflammatory agents on the formalin test in the rat. J. Pharm. Exp. Ther. 263: 136–146.
Neugebauer, V. Geisslinger, G., Ruemenapp, P., Weiretter, F., Szelenyi, I. Brune, K. and Schaible, H.-G., 1995, Antinociceptive effects of R(−) and S(+)-flurbiprofen in rat spinal dorsal horn neurones rendered hyperexcitable by an acute knee joint inflammation. J. Pharm.Exp. Ther. 275: 618–628.
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© 1997 Springer Science+Business Media New York
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Grubb, B.D., Willingale, H.L., Gardiner, N.J., Giblett, S. (1997). Functional Consequences of the Identification and Localisation of Cyclooxygenase Isoforms in Dorsal Horn of Rat Spinal Cord. In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_44
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DOI: https://doi.org/10.1007/978-1-4899-1810-9_44
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