Abstract
Accumulating data suggest that dietary supplementation of fish oils rich in eicosapentaenoic acid (EPA) and eicosapentaenoic acid (DHA) increases susceptibility of isolated low density lipoprotein (LDL) to peroxidation1–4. Oxidative modication of LDL may contribute to tissue damage through cytotoxic reactions with endothelial cells or through further reactions to generate “modified” LDL which is selectively accummulated by “scavenger” receptors5. Therefore, concern has been raised with respect to the high intake of EPA and DHA in numerous trials in the prevention of disease as well as encouragement to self medication by the health food industry.
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References
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Nourooz-Zadeh, J., Halliwell, B., Änggård, E.E. (1997). Formation of a Novel Class of F3-Isoprostanes during Peroxidation of Eicosapentaenoic Acid (EPA). In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_38
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DOI: https://doi.org/10.1007/978-1-4899-1810-9_38
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