Abstract
Thromboxane (TXA2) causes platelet aggregation, vasoconstriction and cell proliferation through the activation of specific cell membrane TP-receptors1, 2. TXA2 is implicated in thrombotic disorders and TP-receptor antagonists have been described as an anti-thrombotic approach3. S 18204 (Fig. 1) is a recently developed orally active and long acting TP-receptor antagonist4. Since S 18204 is a racemic compound, the aim of this study was to select the active isomer (S 18885 or S 18886) of S 18204 on platelet and contractile responses induced by the TP-receptor agonist U 46619 under in vitro, in vivo and ex vivo conditions.
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Simonet, S., Descombes, JJ., Vallez, MO., Dubuffet, T., Lavielle, G., Verbeuren, T.J. (1997). S 18886, a New Thromboxane (TP)-Receptor Antagonist Is the Active Isomer of S 18204 in All Species, Except in the Guinea-Pig. In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_35
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DOI: https://doi.org/10.1007/978-1-4899-1810-9_35
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