Abstract
Arachidonic acid ethanolamide (anandamide), a simple nitrogen-containing lipid, has recently been described as an endogenous ligand to the mammalian CNS cannabinoid receptor (CB1)1. Since its initial characterization, there has been tremendous interest in exploring a diversity of related structures for activity at this receptor from the viewpoint of defining structure-activity relationships at this receptor, discovering pharmacologically useful agonists and antagonists, and defining the role of anandamide metabolism in the modulation of CB1 activation2.
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References
D.A. Devane, L. Hanus, A. Breuer, R.G. Pertwee, L.A. Stevenson., G. Griffin, D. Gibson, A. Mandelbaum, A. Etinger, and R. Mechoulam, Isolation and structure of a brain constituent that binds to the cannabinoid receptor, Science 258: 1946–1949 (1992).
V. Di Marzo, and A. Fontana, Anandamide, an endogenous cannabinomimetic eicosanoid: “Killing two birds with one stone”, in: Prostaglandins, Leukotrienes and Essential Fatty Acids 53: 1–11 (1995).
M.L. Wise, K. Soderstrom, T.F. Murray, and W.H. Gerwick, Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid, Experientia 52: 88–92 (1995).
J.C. Pinto, F. Potie, K.C. Rice, D. Boring, M.R. Johnson, D.M. Evans, G.H. Wilken, C.H. Cantrell, and A.C. Howlett, Cannabinoid receptor binding activity of amides and esters of arachidonic acid, Mol. Pharmacol. 46: 516–522 (1994).
N. Ueda, K. Yamamoto, S. Yamamoto, T. Tokunaga, E. Shirakawa, H. Shinkai, M. Ogawa, T. Sato, I. Kudao, K. Inoue, H. Takizawa, T. Nagano, M. Hirobe, N. Matsuki, H. Saito, Lipoxygenase-catalyzed oxygenation of arachidonylethanolamide, a cannabinoid receptor agonist, Biochim. Biophys. Acta 1254: 127–134 (1995).
A.J. Hampson, W.A.G. Hill, M. San-Phillips, A. Makriyannis, E. Leung, R.M. Eglen, L.M. Bornheim, Anandamide hydroxylation by brain lipoxygenase: Metabolite structures and potencies at the cannabinoid receptor, Biochim. Biophys. Acta 1259: 173–179 (1995).
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Soderstrom, K. et al. (1997). Discovery of Novel Cannabinoid Receptor Ligands from Diverse Marine Organisms. In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_14
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DOI: https://doi.org/10.1007/978-1-4899-1810-9_14
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