Skip to main content
SpringerLink
Log in
Book cover

Fat-Soluble Vitamins pp 29–51Cite as

Retinoid Endocrinology

From Metabolism to Cellular Signaling

  • Chapter

Part of the book series: Subcellular Biochemistry ((SCBI,volume 30))

Abstract

An interplay of differentiative and proliferative factors is necessary for the normal development and maintenance of complex multicellular organisms. Aberrations in this regulatory balance are the basis of developmental abnormalities and diseases such as cancer. One important group of such regulatory factors is the retinoids, a family of structurally related isoprenoid lipids that includes vitamin A alcohol, retinol—the physiological precursor of many bioactive retinoids. Biological activity of retinoids is regulated by retinoid-binding proteins present in extracellular, cytosolic, and nuclear compartments. These retinoid-protein complexes participate in cellular uptake, metabolism, signaling, and homeostasis of retinoids. The nuclear retinoid-binding proteins, called retinoid receptors, are ligand-regulated transcription factors. The retinoid receptors can modulate the expression of genes via a complex network of interactions with corepressors, coactivators, other nuclear hormone receptors, or other components of distinct signaling pathways. Such a network provides a molecular basis for the pleiotropic physiological effects of retinoids.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Achen, M. G., Duan, W., Pettersson, T. M., Hanns, P. J., Richardson, S. J., Lawrence, M. C., Wettenhall, R. E., Aldred, A. R., and Schreiber, G., 1993, Transthyretin gene expression in choroid plexus first evolved in reptiles, Am. J. Physiol. 265:R982-989.

    Google Scholar 

  • Allenby, G., Bocquel, M., Saunders, M., Kazmer, S., Speck, J., Rosenberger, M., Lovey, A., Kastner, P., Grippo, J. F., Chambon, P., and Levin, A. A., 1993, Retinoic acid receptors and retinoid X receptors: Interactions with endogenous retinoic acids, Proc. Natl. Acad. Sci. USA 90:30–34.

    Article  PubMed  CAS  Google Scholar 

  • Angulo, A., Suto, C., Boehm, M. F., Heyman, R. A., and Ghazal, P., 1995, Retinoid activation of retinoic acid receptors but not of retinoid X receptors promotes cellular differentiation and replication of human cytomegalovirus in embryonal cells, J. Virol. 69:3831–3837.

    PubMed  CAS  Google Scholar 

  • Araki, H., Shidoji, Y., Yamada, Y., Moriwaki, H., and Muto, Y., 1995, Retinoid agonist activities of synthetic geranyl geranoic acid derivatives, Biochem. Biophys. Res. Commun. 209:66–72.

    Article  PubMed  CAS  Google Scholar 

  • Bass, N. M., 1993, Cellular binding proteins for fatty acids and retinoids: Similar or specialized functions? Mol. Cell. Biochem. 123:191–202.

    Article  PubMed  CAS  Google Scholar 

  • Bavik, C., Levy, F., Hellman, U., Wernstedt, C., and Eriksson, U., 1993, The retinal pigment epithelial membrane receptor for retinol-binding protein, J. Biol. Chem. 268:20540–20546.

    PubMed  CAS  Google Scholar 

  • Bavik, C., Ward, S. J., and Chambon, P., 1996, Developmental abnormalities in cultured mouse embryos deprived of retinoic by inhibition of yolk-sac retinol binding protein synthesis, Proc. Natl. Acad. Sci. USA 93:3110–3114.

    Article  PubMed  CAS  Google Scholar 

  • Becker, P. S., Li, Z., Potselueva, T., Madri, J. A., Newburger, P. E., and Berliner, N., 1996, Laminin promotes differentiation of NB4 promyelocytic leukemia cells with all-trans retinoic acid, Blood 88:261–267.

    PubMed  CAS  Google Scholar 

  • Bennekum, A., Blaner, W., Seifert-Bock, I., Moukides, M., Brouwer, A., and Hendriks, H. F. J., 1993, Retinol uptake from retinol binding protein by liver parenchymal cells in vitro does not specifically depend on its binding to retinol binding protein, Biochemistry 32:1727–1733.

    Article  PubMed  Google Scholar 

  • Berard, J., Gaboury, L., Landers, M., De Repentigny, Y., Houle, B., Kothary, R., and Bradley, W. E. C., 1994, Hyperplasia and tumors in lung, breast and other tissues in mice carrying a RARβ4-like transgene, EMBO J. 13:5570–5580.

    PubMed  CAS  Google Scholar 

  • Bermudez, A. J., Swayne, D. E., Squires, M. W., and Radin, M. J., 1993, Effects of vitamin A deficiency on the reproductive system of mature White Leghorn hens, Avian Dis. 37:274–283.

    Article  PubMed  CAS  Google Scholar 

  • Berni, R., and Formelli, F., 1992, In vitro interaction of fenretinide with RBP and its functional consequences, FEBS Lett. 308:43–45.

    Article  PubMed  CAS  Google Scholar 

  • Blake, C. C., and Oatley, S. J., 1977, Protein-DNA and protein-hormone interactions in prealbumin, Nature 268:115–120.

    Article  PubMed  CAS  Google Scholar 

  • Blake, C. C., Geisow, M. J., Oatley, S. J., Rerat, B., and Rerat, C., 1978, Structure of prealbumin: Secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 Å, J. Mol. Biol. 121:339–356.

    Article  PubMed  CAS  Google Scholar 

  • Blomhoff, R., Green, M. H., and Norum, K. R., 1992, Vitamin A: Physiological and biochemical processing, Annu. Rev. Nutr. 12:37–57.

    Article  PubMed  CAS  Google Scholar 

  • Boerman, M, and Napoli, J., 1991, Cholate-independent retinyl ester hydrolase, J. Biol. Chem. 266:22273–22278.

    PubMed  CAS  Google Scholar 

  • Boylan, J. F., Lohnes, D., Taneja, R., Chambon, P., and Gudas, L. J., 1993, Loss of RAR γ function by gene disruption results in aberrant Hoxa-1 expression and defective cell differentiation, Proc. Natl. Acad. Sci. USA 90:9601–9605.

    Article  PubMed  CAS  Google Scholar 

  • Buck, J., Ritter, G., Dannecker, L., Katta, V., Cohen, S. L., Chait, B. T., and Hammerling, U., 1990, Retinol is essential for growth of activated human B cells, J. Exp. Med. 171:1613–1624.

    Article  PubMed  CAS  Google Scholar 

  • Cantorna, M. T., Nashold, F. E., Chun, T. Y., and Hayes, C. E., 1996, Vitamin A downregulation of IFN-gamma synthesis in cloned mouse Thl lymphocytes depends on the CD28 costimulatory pathway, J. Immunol. 156:2674–2679.

    PubMed  CAS  Google Scholar 

  • Chambon, P., 1996, A decade of molecular biology of retinoic acid receptors, FASEB J. 10:940–954.

    PubMed  CAS  Google Scholar 

  • Chen, J.-Y., Penco, S., Ostrowski, J., Balaguer, P., Pons, M., Starrett, J. E., Reczek, P., Chambon, P., and Gronemeyer, H., 1995, RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation, EMBO J. 14:1187–1197.

    PubMed  CAS  Google Scholar 

  • Chen, Y., Takeshita, A., Ozaki, K., Kitano, S., and Hanazawa, S., 1996, Transcriptional regulation by transforming growth factor beta of the expression of retinoic acid and retinoid X receptor genes in osteoblastic cells is mediated through AP-1, J. Biol. Chem. 271:31602–31606.

    Article  PubMed  CAS  Google Scholar 

  • Darwiche, N., Scita, G., Jones, C., Rutberg, S., Greenwald, E., Tennenbaum, T., Collins, S. J., De Luca, L. M., and Yuspa, S. H., 1996, Loss of retinoic acid receptors in mouse skin and skin tumors is associated with activation of the ras(Ha) oncogene and high risk for premalignant progression, Cancer Res. 56:4942–4949.

    PubMed  CAS  Google Scholar 

  • DeBoeck, H., and Raphael, Z., 1988, NMR study of the interaction of retinoids with phospho-lipid bilayers, Biochim. Biophys. Acta 946:244–252.

    Article  CAS  Google Scholar 

  • Derguini, F., Nakanishi, K., Hämmerling, U., Chua, R., Eppinger, T., Levi, E., and Buck, J., 1995, 13,14-Dihydroxy-retinol, a new bioactive retinol metabolite, J. Biol. Chem. 270:18875–18880.

    Article  PubMed  CAS  Google Scholar 

  • Desbois, C., Aubert, D., Legrand, C., Pain, B., and Samarut, J., 1991, A novel mechanism of action for v-ErbA: Abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors, Cell 67:731–740.

    Article  PubMed  CAS  Google Scholar 

  • de The, H., 1996, Altered retinoic acid receptors, FASEB J. 10:955–960.

    PubMed  Google Scholar 

  • Divino, C. M., and Schlussler, G., 1990, Receptor-mediated uptake and internalization of transthyretin, J. Biol. Chem. 265:1425–1429.

    PubMed  CAS  Google Scholar 

  • Dmitrovsky, E., Moy, D., Miller, W. H., Jr., Li, A., and Masui, H., 1990, Retinoic acid causes a decline in TGF-alpha expression, cloning efficiency, and tumorigenicity in a human embryonal cancer cell line, Oncogene Res. 5:233–239.

    PubMed  CAS  Google Scholar 

  • Dong, D., and Zile, M. H., 1995, Endogenous retinoids in the early avian embryo, Biochem. Biophys. Res. Commun. 217:1026–1031.

    Article  PubMed  CAS  Google Scholar 

  • Episkopou, V., Maeda, S., Nishiguchi, S., Shimada, K., Gaitanaris, G. A., Gottesman, M. E., and Robertson, E. J., 1993, Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone, Proc. Natl. Acad. Sci. USA 90:2375–2379.

    Article  PubMed  CAS  Google Scholar 

  • Fanjul, A., Dawson, M. I., Hobbs, P. D., Jong, L., Cameron, J. F., Harlev, E., Graupner, G., Lu, X.-P., and Pfahl, M., 1994, A new class of retinoids with selective inhibition of AP-1 inhibits proliferation, Science 372:107–109.

    CAS  Google Scholar 

  • Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z.-Q., Varani, J., Kang, S., and Voorhees, J. J., 1996, Molecular basis of sun-induced premature skin aging and retinoid antagonism, Nature 379:335–339.

    Article  PubMed  CAS  Google Scholar 

  • Flower, D., 1996, The lipocalin protein family: Structure and function, Biochem J. 318:1–14.

    PubMed  CAS  Google Scholar 

  • Forman, B. M., Goode, E., Chen, J., Oro, A. E., Bradley, D. J., Perlmann, T., Noonan, D. J., Burka, L. T., McMorris, T., Lamph, W. W., Evans, R. M., and Weinberger, C., 1995, Identification of a nuclear receptor that is activated by farnesol metabolites, Cell 81:687–693.

    Article  PubMed  CAS  Google Scholar 

  • Fujiki, H., Mori, M., Nakayasu, M., Terada, M., Sugimura, T., and Moore, R. E., 1981, Indole alkaloids: Dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters, Proc. Nad. Acad. Sci. USA 78:3872–3876.

    Article  CAS  Google Scholar 

  • Gerlach, T. H., and Zile, M. H., 1991, Effect of retinoic acid and apo-retinol binding protein on serum retinol concentration in acute renal failure, FASEB J. 5:86–92.

    PubMed  CAS  Google Scholar 

  • Giardiello, F. M, Hamilton, S. R., Hylind, L. M, Yang, V. W., Tamez, P., and Casero, R. A., Jr., 1997, Ornithine decarboxylase and polyamines in familial adenomatous polylosis, Cancer Res. 57:199–201.

    PubMed  CAS  Google Scholar 

  • Giguere, V., Ong, E. S., Segui, P., and Evans, R. M, 1987, A human retinoic acid receptor which belongs to the family of nuclear receptors, Nature 330:624–629.

    Article  PubMed  CAS  Google Scholar 

  • Goodman, D. S., 1984, Plasma retinol-binding protein, in The Retinoids, Vol. 2 (D. S. Goodman, ed.), pp. 41–88, Academic Press, Orlando, Florida.

    Google Scholar 

  • Grandis, J. R., Zeng, Q., and Tweardy, D. J., 1996, Retinoic acid normalizes the increased gene transcription rate of TGF-alpha and EGFR in head and neck cancer cell lines, Nature Med. 2:237–240.

    Article  Google Scholar 

  • Halter, S. A., Winnier, A. R., and Arteaga, C. L., 1993, Pretreatment with vitamin A inhibits transforming growth factor alpha stimulation of human mammary carcinoma cells, J. Cell Physiol. 156:80–87.

    Article  PubMed  CAS  Google Scholar 

  • Harant, H., de Martin, R., Andrew, P. J., Foglar, E., Dittrich, C., and Lindley, I. J. D., 1996, Synergistic activation of interleukine-8 gene transciption by all-trans-retinoic acid and tumor necrosis factor-a involves the transcription factor NF-ϰB, J. Biol. Chem. 271:26954–26961.

    Article  PubMed  CAS  Google Scholar 

  • Heller, J., 1975, Interactions of retinol-binding protein with its receptor, J. Biol. Chem. 250:3613–3619.

    PubMed  CAS  Google Scholar 

  • Herr, F. M., Wradlaw, S. A., Kakkad, B., Albrecht, A., Quick, T. C., and Ong, D. E., 1993, Intestinal vitamin A metabolism: Coordinate distribution of enzymes, J. Lipid Res. 34:1545–1554.

    PubMed  CAS  Google Scholar 

  • Hope, W. C., Patel, B. J., Fiedler-Nagy, C., and Wittreich, B. H., 1990, Retinoids inhibit phospholipase A2 in human synovial fluid and arachidonic acid release from rat peritoneal macrophages, Inflammation 14:543–559.

    Article  PubMed  CAS  Google Scholar 

  • Houle, B., Rochette-Egly, C., and Bradley, W. E., 1993, Tumor suppressive effect of retinoic acid receptor β in human epidermoid lung cancer cells, Proc. Natl. Acad. Sci. USA 90:985–989.

    Article  PubMed  CAS  Google Scholar 

  • Huggenvik, J., Collard, M., Kim, Y., and Sharma, R., 1993, Modification of the retinoic acid signalling pathway by the catalytic subunit of protein kinase A, Mol. Endocrinol. 7:543–550.

    Article  PubMed  CAS  Google Scholar 

  • Joshi, P. S., Mathur, S. N., Murthy, S. K., and Ganguly, J., 1973, Vitamin A economy of the developing chick embryo and of the freshly hatched chick, Biochem J. 136:757–761.

    PubMed  CAS  Google Scholar 

  • Kahl-Rainer, P., Sedivy, R., and Marian, B., 1996, Protein kinase C tissue localization in human colonie tumors suggests a role for adenoma growth control, Gastroenterology 110:1753–1759.

    Article  PubMed  CAS  Google Scholar 

  • Kaji, E. H., and Lodish, H. F., 1993, Unfolding of newly made retinol-binding protein by dithiothreitol. Sensitivity to retinoids, J. Biol. Chem. 268:22188–22194.

    PubMed  CAS  Google Scholar 

  • Kanai, M., Raz, A., and Goodman, D. S., 1968, Retinol-binding protein: The transport protein for vitamin A in human plasma, J. Clin. Invest. 47:2025–2044.

    Article  PubMed  CAS  Google Scholar 

  • Kastner, P., Grondona, J. M., Mark, M., Gansmuller, A., LeMeur, M., Decimo, D., Vonesch, J.-L., Dolle, P., and Chambon, P., 1994, Genetic analysis of RXRa developmental functions: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis, Cell 78:987–1003.

    Article  PubMed  CAS  Google Scholar 

  • Kitareewan, S., Burka, L. T., Tomer, K. B., Parker, C. E., Deterding, L. J., Stevens, R. D., Forman, B. M., Mais, D. E., Heyman, R. A., McMorris, T., and Weinberger, C., 1996, Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR, Mol. Biol. Cell 7:1153–1166.

    PubMed  CAS  Google Scholar 

  • Kopelman, M., Cogan, U., Mokady, S., and Shinitzky, M., 1976, The interaction between retinol-binding proteins and prealbumins studied by fluorescence polarization, Biochim. Biophys. Acta 439:449–460.

    Article  PubMed  CAS  Google Scholar 

  • Kostrouch, Z., Kostrouchova, M., and Rail, J. E., 1995, Steroid/thyroid hormone receptor genes in Caenorhabditis elegans, Proc. Natl. Acad. Sci. USA 92:156–159.

    Article  PubMed  CAS  Google Scholar 

  • Ktistakis, N. T., Brown, H. A., Waters, M. G., Sternweis, P. C., and Roth, M. G., 1996, Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles, J. Cell Biol 134:295–306.

    Article  PubMed  CAS  Google Scholar 

  • Kurlandsky, S. B., Gamble, M. V., Ramakrishnan, R., and Blaner, W. S., 1995, Plasma delivery of retinoic acid to tissues in the rat, J. Biol Chem. 270:17850–17857.

    Article  PubMed  CAS  Google Scholar 

  • Kurlandsky, S. B., Duell, E. A., Kang, S., Voorhees, J. J., and Fisher, G. J., 1996, Autoregulation of retinoic acid biosynthesis through regulation of retinol esterification in human keratinocytes, J. Biol Chem. 271:15346–15352.

    Article  PubMed  CAS  Google Scholar 

  • Langenfeld, J., Lonardo, F., Kiyokawa, H., Passalaris, T., Ahn, M. J., Rusch, V., and Dmitrovsky, E., 1996, Inhibited transformation of immortalized human bronchial epithelial cells by retinoic acid is linked to cyclin E down-regulation, Oncogene 13:1983–1990.

    PubMed  CAS  Google Scholar 

  • Levin, M. S., 1993, Cellular retinol-binding proteins are determinants of retinol uptake and metabolism in stably transfected Caco-2 cells, J. Biol Chem. 268:8267–8276.

    PubMed  CAS  Google Scholar 

  • Li, J. J., Dong, Z., Dawson, M. I., and Colburn, N. H., 1996, Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element, Cancer Res. 56:483–489.

    PubMed  CAS  Google Scholar 

  • Liu, Y., Lee, M. O., Wang, H. G., Li, Y., Hashimoto, Y., Klaus, M, Reed, J. C., and Zhang, X., 1996, Retinoic acid receptor beta mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells, Mol Cell Biol 16:1138–1149.

    PubMed  CAS  Google Scholar 

  • Lohnes, D., Kastner, P., Dierich, A., Mark, M., LeMeur, M., and Chambon, P., 1993, Function of retinoic acid receptor y in the mouse, Cell 73:643–658.

    Article  PubMed  CAS  Google Scholar 

  • Lotan, R., 1996, Retinoids in cancer chemoprevention, FASEB J. 10:1031–1039.

    PubMed  CAS  Google Scholar 

  • Malaba, L., Smeland, S., Senoo, H., Norum, K. R., Berg, T., Blomhoff, R., and Kindberg, G. M., 1995, Retinol-binding protein and asialo-orosomucoid are taken up by different pathways in liver cells, J. Biol Chem. 270:15686–15692.

    Article  PubMed  CAS  Google Scholar 

  • Malpeli, G., Folli, C., and Berni, R., 1996, Retinoid binding to retinol-binding protein and the interference with the interaction with transthyretin, Biochim. Biophys. Acta 1294:48–54.

    Article  PubMed  Google Scholar 

  • Mao, Y., Gurr, J. A., and Hickok, N. J., 1993, Retinoic acid regulates Ornithine decarboxylase gene expression at the transcriptional level, Biochem. J. 295:641–644.

    PubMed  CAS  Google Scholar 

  • Mehta, P., Bertram, J., and Loenstein, W. R., 1989, The actions of retinoids on cellular growth correlate with their actions on gap junctions, J. Cell Biol. 108:1053–1065.

    Article  PubMed  CAS  Google Scholar 

  • Miller, L. A., Zhao, Y. H., and Wu, R., 1996, Inhibition of TGF-alpha gene expression by vitamin A in airway epithelium, J. Clin. Invest. 97:1429–1435.

    Article  PubMed  CAS  Google Scholar 

  • Monaco, H. L., Rizzi, M., and Coda, A., 1995, Structure of a complex of two plasma proteins: Transthyretin and retinol-binding protein, Science 268:1039–1041.

    Article  PubMed  CAS  Google Scholar 

  • Nagpal, S., Friant, S., Nakshatri, H., and Chambon, P., 1993, RARs and RXRs: Evidence for two autonomous transactivation functions and heterodimerization in vivo, EMBO J. 12:2349–2360.

    PubMed  CAS  Google Scholar 

  • Napoli, J., 1996, Retinoic acid biosynthesis and metabolism, FASEB J. 10:993–1001.

    PubMed  CAS  Google Scholar 

  • Noy, N., and Xu, Z., 1990, Interactions of retinol with binding proteins: Implications for cellular uptake mechanisms, Biochemistry 29:3878–3883.

    Article  PubMed  CAS  Google Scholar 

  • Ou, X., Campau, S., Slusher, R., Jasti, R. K., Mabry, M., and Kalemkerian, G. P., 1996, Mechanism of all-trans-retinoic acid-mediated L-myc gene regulation in small cell lung cancer, Oncogene 13:1893–1899.

    PubMed  CAS  Google Scholar 

  • Pan, L, Eckhoff, C., and Brinckerhoff, C. E., 1995, Suppression of collagenase gene expression by all-trans and 9-cis retinoic acid is ligand dependent and requires both RARs and RXRs, J. Cell. Biochem. 57:575–589.

    Article  PubMed  CAS  Google Scholar 

  • Paulik, M., Morre, D. J., and Morre, D. M., 1995, A 55 kDa protein of transitional endoplasmic reticulum from rat liver binds retinol, Biochim. Biophys. Acta 1266:273–277.

    Article  PubMed  Google Scholar 

  • Perry, M. M, Gilbert, A. B., and Evans A. J., 1978, Electron microscope observation on the ovarian follicle of the domestic fowl during the rapid growth phase, J. Anat. 125:481–497.

    PubMed  CAS  Google Scholar 

  • Perry, M. M., Griffin H. D., and Gilbert A. B., 1984, The binding of very low density and low density lipoproteins to the plasma membrane of the hen’s oocyte, Exp. Cell Res. 151:433–446.

    Article  PubMed  CAS  Google Scholar 

  • Petkovich, M., Brand, N. J., Krust, A., and Chambon, P., 1987, A human retinoic acid receptor which belongs to the family of nuclear receptors, Nature 330:444–450.

    Article  PubMed  CAS  Google Scholar 

  • Rask, L., and Peterson, P. A., 1976, In vitro uptake of vitamin A from the retinol-binding plasma protein to mucosal epithelial cells from the monkey’s small intestine, J. Biol. Chem. 251:6360–6366.

    PubMed  CAS  Google Scholar 

  • Roberts, A. B., and Sporn, M. B., 1984, Cellular biology and biochemistry of the retinoids, in The Retinoids, Vol. 2 (D. S. Goodman, ed.), pp. 209–286, Academic Press, Orlando, Florida.

    Google Scholar 

  • Robertson, K., Emami, B., and Collins, S., 1992, Retinoic acid resistant HL60 cells harbour a point mutation in the RAR ligand binding domain that confers dominant negative activities, Blood 80:1885–1892.

    PubMed  CAS  Google Scholar 

  • Rochette-Egly, C., Oulad-Abdelghani, M., Staub, A., Pfister, V., Scheuer I., Chambon, P., and Gaub, M. P., 1995, Phosphorylation of the retinoic acid receptor-alpha by protein kinase A, Mol. Endocrinol. 9:860–871.

    Article  PubMed  CAS  Google Scholar 

  • Ross, A., 1993, Cellular metabolism and activation of retinoids: Roles of cellular retinoid-binding proteins, FASEB J. 7:317–327.

    PubMed  CAS  Google Scholar 

  • Roulier, S., Rochette-Egly, C., Alsat, E., Dufour, S., Porquet, D., and Evain-Brion, D., 1996, EGF increases retinoid X receptor-alpha expression in human trophoblastic cells in culture: Relationship with retinoic acid induced human chorionic gonadotropin secretion, Mol. Cell. Endocrinol 118:125–135.

    Article  PubMed  CAS  Google Scholar 

  • Sawaya, B. E., Rohr, O., Aunis, D., and Schaeffer, E., 1996, Regulation of HIV-1 gene transcription by nuclear receptors in human brain cells, J. Biol. Chem. 271:22895–22900.

    Article  PubMed  CAS  Google Scholar 

  • Schadendorf, D., Kern, M. A., Artuc, M, Pahl, H. L., Rosenbach, T., Fichtner, I., Nrnberg, W., Stting, S., Stebut, E., Worm, M., Makki, A., Jurgovsky, K., Kolde, G., and Henz, B. M., 1996, Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo, J. Cell Biol. 135:1889–1898.

    Article  PubMed  CAS  Google Scholar 

  • Schneider, W. J., Vieira, A. V., MacLachlan, I., and Nimpf, J. N., 1993, Lipoprotein receptor-mediated oocyte growth, in Cellular Metabolism of the Arterial Wall and Central Nervous System (G. Schettler, H. Greten, and A. Habenicht, eds.), pp. 105–115, Springer-Verlag, Berlin.

    Chapter  Google Scholar 

  • Schroeder, C., Gibson, L., and Beug, H., 1992, The v-erbA oncogene requires cooperation with tyrosine kinases to arrest erythroid differentiation induced by ligand-activated endogenous c-erbA and retinoic acid receptor, Oncogene 7:203–216.

    PubMed  CAS  Google Scholar 

  • Shimeld, S. M., 1996, Retinoic acid, HOX genes and the anterior-posterior axis in chordates, Bioessays 18:613–616.

    Article  CAS  Google Scholar 

  • Simeone, A., Acampora, D., Arcioni, L., Andrews, P. W., Boncinelli, E., and Malvillo, F., 1990, Sequencial activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells, Nature 346:763–767.

    Article  PubMed  CAS  Google Scholar 

  • Sivaprasadarao, A., and Findlay, J., 1988, The mechanism of uptake of retinol by plasma membrane vesicles, Biochem. J. 255:571–579.

    PubMed  CAS  Google Scholar 

  • Takahashi, N., and Breitman, T., 1989, Retinoic acid acylation (retinoylation) of a nuclear protein in the human acute myeloid leukemia cell line HL60, J. Biol. Chem. 264:5159–5163.

    PubMed  CAS  Google Scholar 

  • Terry, C. J., Damas, A. M., Oliveira, P., Saraiva, M. J., Alves, I. L., Costa, P. P., Matias, P. M., Sakaki, Y., and Blake, C. C., 1993, Structure of Met30 variant of transthyretin and its amyloidogenic implications, EMBO J. 12:735–741.

    PubMed  CAS  Google Scholar 

  • Thompson, J., McHowell, J., Pitt, G., and McLaughlin, C., 1969, The biological activity of retinoic acid in the domestic fowl and the effects of vitamin A deficiency on the chick embryo, Br. J. Nutr. 23:471–490.

    Article  PubMed  CAS  Google Scholar 

  • Tornabene, T. G., Langworthy, T. A., Holzer, G., and Oro, J., 1979, Squalenes, phytanes and other isoprenoids as major neutral lipids of methanogenic and thermoacidophilic “Archaebacteria,” J. Mol. Evol. 13:73–83.

    Article  PubMed  CAS  Google Scholar 

  • Tsao, Y.-P., Li, S.-F., Kuo, S.-W., Liu, J.-C., and Chen, S.-L., 1996, Reversal of the temperature-shift-induced growth restriction of a temperature-sensitive simian virus 40 T-antigentransformed human fibroblast cell line by treatment with retinoic acid, Biochem. J. 317:707–711.

    PubMed  CAS  Google Scholar 

  • Tsutsumi, C., Okuno, M., Tannous, L., Piantedossi, R., Allan, M., Goodman, D. S., and Blaner, W. S., 1992, Retinoids and retinol-binding protein expression in rat liver adipocytes, J. Biol. Chem. 267:1805–1810.

    PubMed  CAS  Google Scholar 

  • Urano, S., Inomori, Y., Sugawara, T., Kato, Y., Kitahara, M., Hasegawa, Y., Matsuo, M., and Mukai, K., 1992, Vitamin E: Inhibition of retinol-induced hemolysis and membrane-stabilizing behavior, J. Biol. Chem. 267:18365–18370.

    PubMed  CAS  Google Scholar 

  • Vennstrom, B., and Bishop, J. M., 1982, Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virus, Cell 28:135–143.

    Article  PubMed  CAS  Google Scholar 

  • Vieira, A. V., 1994, Characterization of the avian retinol-binding protein-transthyretin complex and its role in oocytic endocytosis of retinol, Ph.D. Thesis, University of Alberta, Edmonton, Alberta, Canada.

    Google Scholar 

  • Vieira, A. V., and Schneider, W. J., 1993, Transport and uptake of retinol during chicken oocyte growth, Biochim. Biophys. Acta 1169:250–256.

    Article  PubMed  CAS  Google Scholar 

  • Vieira, A. V., Sanders, E. J., and Schneider, W. J., 1995a, Transport of serum transthyretin into chicken oocytes, a receptor-mediated mechanism, J. Biol. Chem. 270:2952–2956.

    Article  PubMed  CAS  Google Scholar 

  • Vieira, A. V., Schneider, W. J., and Vieira, P. M., 1995b, Retinoids: Transport, metabolism, and mechanisms of action, J. Endocrinol. 146:201–207.

    Article  PubMed  CAS  Google Scholar 

  • Wahlberg, P., Fex, G., and Wennerberg, J., 1989, A relationship between retinol and cellular retinol-binding protein concentrations in human squamous cell carcinomas, Biochim. Biophys. Acta 1010:287–293.

    Article  PubMed  CAS  Google Scholar 

  • Wang, W., Napoli, J. L., and Ballow, M., 1993, The effects of retinol on in vitro Immunoglobulin synthesis by cord blood and adult peripheral blood mononuclear cells, Clin. Exp. Immunol. 92:164–168.

    Article  PubMed  CAS  Google Scholar 

  • Wang, X. D., Russell, R. M, Liu, C., Stickel, F., Smith, D. E., and Krinsky, N. I., 1996, Beta-oxidation in rabbit liver in vitro and in the perfused ferret liver contributes to retinoic acid biosynthesis from beta-apocarotenoic acids, J. Biol. Chem. 271:26490–26498.

    Article  PubMed  CAS  Google Scholar 

  • Wei, S., Episkopou, V., Piantedosi, R., Maeda, S., Shimada, K., Gottesman, M. E., and Blaner, W. S., 1995, Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombination, J. Biol. Chem. 270:866–870.

    Article  PubMed  CAS  Google Scholar 

  • Woods, J., Woodward, M., and Roth, T., 1978, Selective protein uptake, J. Cell Sci 30:87–97.

    PubMed  CAS  Google Scholar 

  • Xiao, Y., Desai, D., Quick, T. C., and Niles, R. M., 1996, Control of retinoic acid receptor expression in mouse melanoma cells by cyclic AMP, J. Cell. Physiol. 167:413–421.

    Article  PubMed  CAS  Google Scholar 

  • Zheng, Z. S., Xue, G. Z., and Prystowsky, J. H., 1995, Regulation of the induction of Ornithine decarboxylase in keratinocytes by retinoids, Biochem. J. 309:159–165.

    PubMed  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Amandio V. Vieira

    Present address: Department of Biochemistry, National Public Health Institute-KTL, FIN-00300, Helsinki, Finland

Authors and Affiliations

  1. Department of Cell Biology, The Scripps Research Institute, La Jolla, California, 92037, USA

    Amandio V. Vieira

Authors
  1. Amandio V. Vieira
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. King’s College London, University of London, London, UK

    Peter J. Quinn

  2. Department of Environmental and Occupational Health, and Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Valerian E. Kagan

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

Vieira, A.V. (1998). Retinoid Endocrinology. In: Quinn, P.J., Kagan, V.E. (eds) Fat-Soluble Vitamins. Subcellular Biochemistry, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1789-8_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-1789-8_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1791-1

  • Online ISBN: 978-1-4899-1789-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation