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Lipidic Signaling and Peroxisomal Function

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Fat-Soluble Vitamins

Part of the book series: Subcellular Biochemistry ((SCBI,volume 30))

Abstract

While the important role of lipids in relation to cellular signaling is firmly established and in general well reviewed (Exton, 1994; Barrett, 1992), several novel aspects of the subject have only recently come to light, which involve peroxisomal function, and which appear deserving of further commentary.

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References

  • Ames, B. N., Shigenaga, M. K., and Hagen, T. M., 1993, Oxidants, antioxidants and the degenerative diseases of ageing, Proc. Natl. Acad. Sci. USA 90:7915–7922.

    Article  PubMed  CAS  Google Scholar 

  • Asaoka, Y., Nakamura, S., Yoshida, K., and Nishizuka, Y., 1992, Protein kinase C., calcium and phospholipid degradation, Trends Biochem. Sci. 17:414–448.

    Article  PubMed  CAS  Google Scholar 

  • Barritt, G. J., 1992, Communication within Animal Cells, Oxford University Press, Oxford.

    Google Scholar 

  • Bieri, F., 1993, Peroxisome proliferators and cellular signalling pathways. A review, Biol. Cell 77:43–46.

    Article  PubMed  CAS  Google Scholar 

  • Black, S. D., and Coon, M. J., 1987, P450 cytochromes: Structure and function, Adv. Enzymol. 60:35–87.

    PubMed  CAS  Google Scholar 

  • Budowski, P., 1988, Omega-3 fatty acids in health and disease, World Rev. Nutr. Dietet. 57:214–274.

    CAS  Google Scholar 

  • Chance, B., Sies, H., and Boveris, A., 1979, Hydroperoxide metabolism in mammalian organs, Physiol. Rev. 59:527–605.

    PubMed  CAS  Google Scholar 

  • Crane, D., and Masters, C., 1986, The effect of Clofibrate on the phospholipid composition of peroxisomal membranes in mouse liver, Biochim. Biophys. Acta 876:256–263.

    Article  PubMed  CAS  Google Scholar 

  • Crane D., Zamattia, J., and Masters, C. J., 1990, Alterations in the integrity of peroxisomal membranes in livers of mice treated with peroxisome proliferators, Mol. Cell. Biochem, 96:153–161.

    Article  PubMed  CAS  Google Scholar 

  • De Duve, G. 1983, Microbodies in the living cell, Sci. Am. 248:74–84.

    Google Scholar 

  • De Duve, C., and Baudhuin, P., 1966, Peroxisomes (microbodies and related particles), Physiol. Rev. 46:323–357.

    PubMed  Google Scholar 

  • Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., and Wahli, W., 1996, The PPARα-leukotriene B4 pathway to inflammation control, Nature 384:39–43.

    Article  PubMed  CAS  Google Scholar 

  • Exton, J., 1994, Phosphatidyl choline breakdown and signal transduction, Biochim. Biophys. Acta 1212:26–42.

    Article  PubMed  CAS  Google Scholar 

  • Gibson, G. G., 1989, Comparative aspects of the mammalian cytochrome P450IV gene family, Xenobiotica 19:1123–1148.

    Article  PubMed  CAS  Google Scholar 

  • Green, S., 1992, Receptor-mediated mechanisms of peroxisome proliferators, Biochem. Pharmacol. 43:393–401.

    Article  PubMed  CAS  Google Scholar 

  • Hansen, H. S., 1994, New biological and clinical roles for the ω-6 and ω-3 fatty acids, Nutr. Rev. 52:162–167.

    Article  PubMed  CAS  Google Scholar 

  • Kiss, Z., and Anderson, W. H., 1994, Hydrogen peroxide regulates phospholipase D mediated hydrolysis of phosphatidylethanolamine and phosphatidylcholine by different mechanisms in NIH 3T3 fibroblasts, Arch. Biochem. Biophys. 311:430–436.

    Article  PubMed  CAS  Google Scholar 

  • Lehninger, A. L., Nelson, D. L., and Cox, M. M., 1993, Principles of Biochemistry, Worth, New York.

    Google Scholar 

  • Maksymowych, A. B., Hsu, T. C., and Litwack, G., 1992, A novel highly conserved structural motif is present in all members of the steroid hormone receptor superfamily, Receptor 2:225–240.

    PubMed  CAS  Google Scholar 

  • Masters, C., 1996a, Omega-3 fatty acids and the peroxisome, Mol. Cell. Biochem. 145:83–93.

    Google Scholar 

  • Masters, C., 1996b, Cellular signalling: The role of the peroxisome, Cell Signal. 8:197–208.

    Article  PubMed  CAS  Google Scholar 

  • Masters, C., and Crane, D., 1984, The role of the peroxisomes in lipid metabolism, Trends Biochem. Sci. 9:314–317.

    Article  CAS  Google Scholar 

  • Masters, C., and Crane, D., 1995a, The Peroxisome—A Vital Organelle, Cambridge University Press, Cambridge.

    Google Scholar 

  • Masters, C., and Crane, D., 1995b, On the role of the peroxisome in ontogeny, aging and degenerative disease, Mech. Ageing 80:69–83.

    Article  CAS  Google Scholar 

  • Masters, C., and Crane, D., 1996, Recent developments in peroxisome biology, Endeavour 20:68–73.

    Article  PubMed  CAS  Google Scholar 

  • Masters, C., and Crane, D., 1998, On the role of the peroxisome in the metabdism of drugs and xenobiotics, Biochem. Pharmacol, (in press).

    Google Scholar 

  • Motojima, K., 1993, Peroxisome proliferator activated receptor (PPAR)—Structure, mechanisms of action and diverse function, Cell Struct. Funct. 18:267–277.

    Article  PubMed  CAS  Google Scholar 

  • Osmundsen, H., Bremer, J., and Pedersen, J. I., 1991, Metabolic aspects of β-Oxidation, Biochim. Biophys. Acta 1085:141–158.

    Article  PubMed  CAS  Google Scholar 

  • Pederson, J. I., 1993, Peroxisomal oxidation of the steroid side chain in bile acid formation, Biochimie 75:159–165.

    Article  Google Scholar 

  • Reddy, J. K., Usuda, N., and Rao, M. S., 1988, Hepatic peroxisome proliferation: An overview, Arch. Toxicol. Suppl. 12:207–216.

    Article  CAS  Google Scholar 

  • Stadtman, E. R., 1990, Metal ion catalysed oxidation of proteins: Biochemical mechanism and biological consequences, Free Radic Biol. Med. 9:315–325.

    Article  PubMed  CAS  Google Scholar 

  • Tronchere, H., Record, M., Terce, F., and Chap, H., 1994, Phosphatidyl choline cycle and regulation of phosphatidyl choline biosynthesis by enzyme translocation, Biochim. Biophys. Acta 1212:137–151.

    Article  PubMed  CAS  Google Scholar 

  • Van Kuijk, F. J. G. M., Sevanian, A., Handelman, G. J., and Dratz, E. A., 1987, A new role for phospholipase A2: Protection of membranes from lipid peroxidation damage, Trends Biochem. Sci. 12:31–33.

    Article  Google Scholar 

  • Von Schacky, C., Kiefl, R., Marcus, A. J., Breckman, M. J., and Kaminsky, W. E., 1993, Dietary n-3 fatty acids accelerate catabolism of leukotriene B4 in human granulocytes, Biochim. Biophys. Acta 1166:20–24.

    Article  Google Scholar 

  • Yuan, Y., Jackson, S. P., Newnham, H. H., Mitchell, C. A., and Salem H. H., An essential role for lysophosphatidylcholine in the inhibition of platelet aggregation by secretory phospholipase, Blood 86:4166-4171.

    Google Scholar 

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© 1998 Springer Science+Business Media New York

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Masters, C. (1998). Lipidic Signaling and Peroxisomal Function. In: Quinn, P.J., Kagan, V.E. (eds) Fat-Soluble Vitamins. Subcellular Biochemistry, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1789-8_18

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  • DOI: https://doi.org/10.1007/978-1-4899-1789-8_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1791-1

  • Online ISBN: 978-1-4899-1789-8

  • eBook Packages: Springer Book Archive

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