Skip to main content

Vitamin E

Its Role in Aging

  • Chapter
Fat-Soluble Vitamins

Part of the book series: Subcellular Biochemistry ((SCBI,volume 30))

Abstract

All living organisms undergo irreversible and progressive changes with time in their biological functions. Although some of these changes, namely those associated with growth and development, are not thought of in terms of “aging,” other, deteriorative changes are. Thus, one can consider “aging” as the accumulation of changes with the passage of time that increase the risk of death (Upton, 1977; Kohn, 1985; Harman, 1994).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Amemiya, T., 1981, Effect of vitamin E administration on photoreceptor outer segment and retinal pigment epithelium of vitamin E deficient rats, Int. J. Vitamin Nutr. Res. 51:114–118.

    CAS  Google Scholar 

  • Ames, B. N., 1989, Endogenous DNA damage as related to cancer and aging, Mutat. Res. 214:41–46.

    Article  PubMed  CAS  Google Scholar 

  • Ames, B. N., Shigenaga, M. K., and Hagen, T. M., 1993, Oxidants, antioxidants, and the degenerative diseases of aging, Proc. Natl. Acad. Sci. USA 90:7915–7922.

    Article  PubMed  CAS  Google Scholar 

  • Balin A. K., Goodman, D. B. P., Rasmussen, H., and Cristofalo, V. J., 1977, The effect of oxygen and vitamin E on the life span of human diploid cells in vitro, J. Cell. Biol. 74:58–67.

    Article  PubMed  CAS  Google Scholar 

  • Blackett, A. D., and Hall, D. A., 1981, The effect of vitamin E on mouse fitness and survival, Gerontology 27:133–139.

    Article  PubMed  CAS  Google Scholar 

  • Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Landum, R. W., Cheng, M. S., Wu, J. F., and Floyd, R. A., 1991, Reversal age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin trapping compound N-tert-butyl-α-phenylnitrone, Proc. Natl. Acad. Sci. USA 88:3633–3636.

    Article  PubMed  CAS  Google Scholar 

  • Chia, L. S., Thompson, J. E., and Moscarello, M. A., 1983, Changes in lipid phase behavior in human myelin during maturation and aging, FEBS Lett. 157:155–158.

    Article  PubMed  CAS  Google Scholar 

  • Corwin, L. M., and Shloss, J., 1980, Role of antioxidants in the stimulation of the mitogen response, J. Nutr. 110:2497–2505.

    PubMed  CAS  Google Scholar 

  • Creter, D., Pavlotzky, F., and Savir, H., 1979, Effect of vitamin E on platelet aggregation in diabetic retinopathy, Acta Haematol. 62:74–77.

    Article  PubMed  CAS  Google Scholar 

  • Cutler, R. G., 1984, Antioxidants, aging, and longevity, in Free Radicals in Biology, Vol. 6 (W. A. Pryor, ed.), pp. 371–428, Academic Press, Orlando, Florida.

    Google Scholar 

  • Davies, K. J. A., 1987, Protein damage and degeneration by oxygen radical, I. general aspect, J. Biol. Chem. 262:9895–9901.

    PubMed  CAS  Google Scholar 

  • Dillard, C. J. E., Dumelin, E. E., and Tappel, A. L., 1978, Effects of dietary vitamin E, selenium and polyunsaturated fats on in vivo lipid peroxidation in the rat as measured by pentane production, Lipids 13:396–402.

    Article  PubMed  CAS  Google Scholar 

  • Douglas, C. E., Chan, A. C., and Choy, P. C., 1986, Vitamin E inhibits platelet phospholipase A2, Biochim. Biophys. Acta 876:639–645.

    Article  PubMed  CAS  Google Scholar 

  • Enesco, H. E., and Verdone-Smith, C., 1980, Alpha-tocopherol increases life span in the rotifer Philodina, Exp. Gerontol. 15:335–338.

    Article  CAS  Google Scholar 

  • Enesco, H. E., Bozovic, V., and Anderson, P. D., 1989, The relationship between life span and reproduction in the rotifer Asplanchna brightwelli, Mech. Ageing Dev. 48:281–289.

    Article  PubMed  CAS  Google Scholar 

  • Esterbauer, H., Gebicki, J., Puhl, H., and Jurgens, G., 1992, The role of lipid peroxidation and antioxidants in oxidative modification of LDL, Free Radic. Biol. Med. 13:341–390.

    Article  PubMed  CAS  Google Scholar 

  • Esterbauer, H., Puhl, H., Waeg, G., Krebs, A., and Dieber-Rotheneder, M., 1993, The role of vitamin E in lipoprotein oxidation, in Vitamin E in Health and Disease (L. Packer and J. Fuchs, eds.), pp. 649–671, Marcel Dekker, New York.

    Google Scholar 

  • Farrell, P. M., 1980, Deficiency states, pharmacological effect, and nutrient requirements, in Vitamin E, A Comprehensive Treatise (L. J. Machlin, ed.), pp. 520–620, Marcel Dekker, New York.

    Google Scholar 

  • Floyd, R. A., 1991, Role of oxygen free radicals in carcinogenesis and brain ischemia, FASEB J. 4:2587–2597.

    Google Scholar 

  • Fraga, C. G., Shigenaga, M. K., Park, J.-W., Degan, P., and Ames, B. N., 1990, Oxidative damage to DNA during aging: 8-Hydroxy-2′-deoxyguanosine in rat organ DNA and urine, Proc. Natl. Acad. Sci. USA 87:4533–4537.

    Article  PubMed  CAS  Google Scholar 

  • Francois, C., Nguyen-Legros, J., and Percheron, G., 1981, Topographical and cytological localization of iron in rat and monkey brains, Brain Res. 215:317–322.

    Article  PubMed  CAS  Google Scholar 

  • Fridovich, I., 1983, Superoxide radical: An endogenous toxicant, Annu. Rev. Pharmacol. Toxicol. 23:239–257.

    Article  PubMed  CAS  Google Scholar 

  • Fukuzawa, K., Kurotori, Y., Tokumura, A., and Tsukatani, H., 1989, Vitamin E deficiency increases the synthesis of platelet-activating factor (PAF) in rat polymorphonuclear leucocytes, Lipids 24:236–239.

    Article  PubMed  CAS  Google Scholar 

  • Ghiselli, A., Laurenti, O., Mattia, G. D., Maiani, G., and Ferro-Luzzi, A., 1992, Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients, Free Radic. Biol. Med. 13:621–626.

    Article  PubMed  CAS  Google Scholar 

  • Gisinger, C., Watanabe, J., and Colwell, J. A., 1990, Vitamin E and platelet eicosanoids in diabetes millitus, Prostaglandins Leukotrienes Essential Fatty Acids 40:169–176.

    Article  CAS  Google Scholar 

  • Haberland, M. E., Fless, G. M., Scanu, A. M., and Fogelman, A. M., 1992, Malondialdehyde modification of lipoprotein produces avid uptake by human monocyte-macrophages, J. Biol. Chem. 267:4143–4151.

    PubMed  CAS  Google Scholar 

  • Hafeman, D. G., and Hoekstra, W. G., 1977, Lipid peroxidation in vivo during vitamin E and selenium deficiency in the rats as monitored by ethane evolution, J. Nutr. 107:666–672.

    PubMed  CAS  Google Scholar 

  • Halliwell, B., 1989, Oxidants and the central nervous system: Some fundamental questions, Acta Neurol. Scand. 126:23–33.

    Article  CAS  Google Scholar 

  • Halliwell, B., and Gutteridge, J. M. C., 1985, The importance of free radicals and catalytic metal ions in human diseases, Mol. Aspects Med. 8:189–193.

    Article  Google Scholar 

  • Hammond, B., Kontos, H. A., and Hess, M. L., 1985, Oxygen radicals in the adult respiratory distress syndrome, in madrigal ischemia and reperfusion injury, and in cerebral vascular damage, J. Physiol. Pharmacol. 63:173–187.

    Article  CAS  Google Scholar 

  • Harman, D., 1956, Aging, A theory based on free radical and radiation chemistry, J. Gerontol. 11:298–300.

    Article  PubMed  CAS  Google Scholar 

  • Harman, D., 1982, The free-radical theory of aging, in Free Radicals in Biology, Vol. 5 (W. A. Pryor, ed.), pp. 255–275, Academic Press, Orlando, Florida.

    Google Scholar 

  • Harman, D., 1986, Free radical theory of aging: Role of free radicals in the origination and evolution of life, aging and disease process, in Free Radicals, Aging, and Degenerative Disease (J. E. Johnson, ed.), pp. 3–49, Alan R. Liss, New York.

    Google Scholar 

  • Harman, D., 1992, Free radical theory of aging, Mutat. Res. 275:257–266.

    Article  PubMed  CAS  Google Scholar 

  • Harman, D., 1994, Aging: Prospects for further increases in the functional life span, Age 17:119–146.

    Article  CAS  Google Scholar 

  • Harman, D., 1995, Role of antioxidant nutrients in aging: Overview, Age 18:51–62.

    Article  CAS  Google Scholar 

  • Hatman, L. J., and Kayden, H. J., 1979, A high-performance liquid Chromatographic method for the determination of tocopherol in plasma and cellular elements of the blood, J. Lipid Res. 20:639–645.

    Google Scholar 

  • Hayakawa, M., Hattori, K., Sugiyama, S., and Ozawa, T., 1992, Age associated oxygen damage and mutations in mitochondrial DNA in human hearts, Biochem. Biophys. Res. Commun. 189:979–985.

    Article  PubMed  CAS  Google Scholar 

  • Hennig, B., and Chow, C. K., 1988, Lipid peroxidation and endotherial cell injury: Implications in atherosclerosis, Free Radic Biol. Med. 4:99–106.

    Article  PubMed  CAS  Google Scholar 

  • Hennig, B., Boissonneault, G. A., and Wang, Y., 1989, Protective effects of vitamin E in age-related endotherial cell injury, Int. J. Vitamin Nutr. Res. 59:273–279.

    CAS  Google Scholar 

  • Hirai, S., and Yoshikawa, M., 1970, Vitamin E and aging of the nervous system, in Proceedings International Symposium on Vitamin E (N. Shimazono and Y. Takagi, eds.), pp. 228–237, Kyoritsu Shuppan, Tokyo.

    Google Scholar 

  • Hope, W. C., Dalton, C., and Machlin, L. J., 1975, Influence of vitamin E on Prostaglandin biosynthesis rat blood, Prostaglandins 10:577–567.

    Google Scholar 

  • Kahn, M., and Enesco, H. E., 1981, Effect of α-tocopherol on the life span of Vrbatrix aceti, Age 4:109–115.

    Article  CAS  Google Scholar 

  • Kay, M. M. B., Bosman, G. J. C. G. M., Shapiro, S. S., Bendich, A., and Nassal P. S., 1986, Oxidation as a possible mechanism of cellular aging: Vitamin E deficiency causes premature aging and IgG binding to erythrocytes, Proc. Natl. Acad. Sci. USA 83:2463–2467.

    Article  PubMed  CAS  Google Scholar 

  • Kita, T., Nagano, Y., Yokode, M., Ishii, K., Kume, N., Ooshima, A., Yoshida, H., and Kawai, C., 1987, Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits, Proc. Natl. Acad. Sci. USA 84:5928–5931.

    Article  PubMed  CAS  Google Scholar 

  • Kohn, R. R., 1985, Aging and age-related diseases: Normal processes, in Relation between Normal Aging and Disease (H. A. Johnson, ed.), pp. 1–44, Raven Press, New York.

    Google Scholar 

  • Kruk, P., and Enesco, H. E., 1981, Tocopherol reduces fluorescent age pigment levels in heart and brain of young mice, Experimentia 37:1301–1302.

    Article  CAS  Google Scholar 

  • Ku, H. H., Brunk, U. T., and Sohal, R. S., 1993, Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species, Free Radic. Biol. Med. 15:621–627.

    Article  PubMed  CAS  Google Scholar 

  • Ledvina, M., and Hodanova, M., 1980, The effect of simultaneous administration of tocopherol and sunflower oil on the life span of female mice, Exp. Gerontol. 15:67–71.

    Article  PubMed  CAS  Google Scholar 

  • Machlin, L. J., Filipski, R., and Kuhn, D. C., 1975, Influence of vitamin E on platelet aggregation and thrombocytopenia in rat, Proc. Soc. Exp. Biol. Med. 149:275–277.

    Article  PubMed  CAS  Google Scholar 

  • Masuda, M., Ihara, N., Kuriki, H., Komiyama, Y., Nishikado, H., Egawa, H., and Murata, K., 1989, Spontaneous injuries in the aortic endotherium of the inherited cataract rats and their prevention by tocopherol, Atherosclerosis 75:23–30.

    Article  PubMed  CAS  Google Scholar 

  • McCord, J. M., and Fridovich, I., 1969, Superoxide dismutase, An enzymic function for erythrocuprein, J. Biol. Chem. 244:6049–3055.

    CAS  Google Scholar 

  • Metzger, Z., Hoffeld, J. T., and Oppenheim, J. J., 1980, Macrophage-mediated suppression I. Evidence for participation of both hydrogen peroxide and Prostaglandin of suppression of murine lymphocyte proliferation, J. Immunol. 124:983–988.

    PubMed  CAS  Google Scholar 

  • Meydani, S. N., and Tengerdy, R. P., 1991, Vitamin E and immune response, in Vitamin E: Biochemical Clinical Applications (L. Packer and J. Fuchs, eds.), pp. 549–561, Marcel Dekker, New York.

    Google Scholar 

  • Meydani, S. N., Meydani, M., Verdon, C. P., Blumberg, J. P., and Hayes, K. C. (1986). Vitamin E supplementation suppresses Prostaglandin E2 synthesis and enhances immune response of aged mice, Mech. Ageing Dev. 34:191–201.

    Article  PubMed  CAS  Google Scholar 

  • Miquel, J., Binnard, R., and Howard, W. H., 1973, Effect of d1-α-tocopherol on the life span of Drosophila melanogaster, Gerontologist 13:37.

    Google Scholar 

  • Muller, D. P. R., Lloyd, J. K., and Wolff, O. H., 1983, Vitamin E and neurological function: Abetalipoproteinaemia and other disorders of fat absorption, in Ciba foundation Symposium 101, Biology of Vitamin E, pp. 106–121, Pitman, London.

    Google Scholar 

  • Munnell, J. F., and Getty, R., 1968, Rate of accumulation of cardiac lipofuscin in the aging canine, J. Gerontol. 23:154–158.

    Article  PubMed  CAS  Google Scholar 

  • Nelson, J. S., 1980, Phathology of vitamin E deficiency, in Vitamin E—A Comprehensive Treatise (L. J. Machlin, ed.), pp. 397–428, Marcel Dekker, New York.

    Google Scholar 

  • Okuma, M., Takayama, H., and Uchino, H., 1980, Generation of prostacycline-like substance and lipid peroxidation in vitamin E-deficient rats, Prostaglandin, 19:527–536.

    Article  CAS  Google Scholar 

  • Oliver, C. N., Ahn, B.-W., Moerman, E. J., Goldstein, S., and Stadtman, E. R., 1987, Age-related changes in oxidised proteins, J. Biol. Chem. 262:5488–5491.

    PubMed  CAS  Google Scholar 

  • Ouahchi, K., Arita, M., Kayden, H., Hentati, F., Hanida, M. B., Sokol, R., Arai, H., Inoue, K., Mandel, J.-L., and Koenig, M., 1995, Ataxia with isolated vitamin E deficiency is caused by mutations in the α-tocopherol transfer protein, Nature Genet, 9:141–145.

    Article  PubMed  CAS  Google Scholar 

  • Packer, L., and Smith, J. R., 1974, Extension of the life span of cultured normal human diploid cells by vitamin E, Proc. Natl. Acad. Sci. USA 71:4763–4767.

    Article  PubMed  CAS  Google Scholar 

  • Packer, L., and Smith, J. R., 1977, Extension of the life span of cultured normal human diploid cells by vitamin E. A reevaluation, Proc. Natl. Acad. Sci. USA 74:1640–1641.

    Article  PubMed  CAS  Google Scholar 

  • Papafrangos, E. D., and Lyman, C. P., 1982, Lipofuscin accumulation and hibernation in the Turkish hamster, Mesocricetes brandti, J. Gerontol. 37:417–421.

    Article  CAS  Google Scholar 

  • Parthasarathy, S., Khoo, J. C., Miller E., Barnett, J., Witztum, J. L., and Steinberg, D., 1990, Low density lipoprotein rich in oleic acid is protected against oxidative modification: Implications for dietary prevention of atherosclerosis, Proc. Natl. Acad. Sci. USA 87:3894–3898.

    Article  PubMed  CAS  Google Scholar 

  • Pichard, K. A., Karpen, C. W., and Merola, C. W., 1982, Influence of dietary vitamin C on platelet thromboxane A2 and vascular prostacycline I2 in rabbit, Prostaglandins Leukotrienes Med. 9:373–378.

    Article  Google Scholar 

  • Porta, E. A., Joun, N. S., and Nitta, R. T., 1980, Effects of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging, Mech. Ageing Dev. 13:1–39.

    Article  PubMed  CAS  Google Scholar 

  • Pryor, W. A., 1982, Free radical biology: Xenobiotics, cancer and aging, Ann. N. Y. Acad. Sci. 393:1–22.

    Article  PubMed  CAS  Google Scholar 

  • Reddy, K., Fletcher, B., Tappel, A., and Tappel, A. L., 1973, Measurement and spectral characteristics of fluorescent pigments in tissues of rats as a function of dietary polyunsaturated fats and vitamin E, J. Nutr. 103:908–915.

    PubMed  CAS  Google Scholar 

  • Sack, C. A., Socci, D. J., Crandall, B. M., and Arendash, G. W., 1996, Antioxidant treatment with phenyl-a-tert-butylnitron (PBN) improves the cognitive performance and survival of aging rats, Neurosci. Lett. 205:181–184.

    Article  PubMed  CAS  Google Scholar 

  • Sakagami, H., and Yamada, M., 1977, Failure of vitamin E to extend the life span of a human diploid cell line in culture, Cell Struct. Funct. 2:219–227.

    Article  CAS  Google Scholar 

  • Sawada, M., and Enesco, H. E., 1984, Vitamin E extends life span in the short-lived rotifer Asplanchna brightwelli, Exp. Gerontol. 19:179–183.

    Article  PubMed  CAS  Google Scholar 

  • Sawada, M., and Carlson, J. C., 1987a, Changes in Superoxide radical and lipid peroxide formation in the brain, heart and liver during the life span of the rat, Mech. Aging Dev. 41:125–137.

    Article  PubMed  CAS  Google Scholar 

  • Sawada, M., and Carlson, J. C., 1987b, Association between lipid peroxidation and life modifying factors in rotifers, J. Gerontol. 42:451–456.

    Article  PubMed  CAS  Google Scholar 

  • Shirai, K., Matsuoka, N., Morisaki, N., Murano, S., Sasaki, N., Shinoyama, N., Saito, Y., Kumagai, A., and Mizobuchi, M., 1980, Effect of tocopherol deficiency on lipid metabolism in the arterial wall of rats on normal and high cholesterol diet, Artery 6:484–506.

    PubMed  CAS  Google Scholar 

  • Socci, D. J., Crandall, B. M., and Arendash, G. W., 1995, Chronic antioxidant treatment improves the cognitive performance of aged rats, Brain Res. 693:88–94.

    Article  PubMed  CAS  Google Scholar 

  • Sohal, R. S., Farmer, K. J., Allen, R. G., and Ragland, S. S., 1984, Effects of diethyldithiocarbamate on life span, metabolic rate, Superoxide dismutase, catalase, inorganic peroxide and glutathione in the adult male housefly, Mech. Ageing Dev. 24:175–183.

    Article  PubMed  CAS  Google Scholar 

  • Sokol, R. J., 1989, Vitamin E and neurologic function in man, Free Radic. Biol Med. 6:189–207.

    Article  PubMed  CAS  Google Scholar 

  • Stampfer, M. J., Hennekens, C. H., Manson, J. E., Colditz, G. A., Rosner, B., and Willett, W., 1993, Vitamin E consumption and the risk of coronary disease in women, N. Engl. J. Med. 328:1444–1449.

    Article  PubMed  CAS  Google Scholar 

  • Starke-Reed, P. E., and Oliver, C. N., 1989, Protein oxidation and proteolysis during aging and oxidative stress, Arch. Biochem. Biophys. 275:559–567.

    Article  PubMed  CAS  Google Scholar 

  • Steinbrecher, U. P., Zhang, H., and Lougheed, M., 1990, Role of oxidatively modified LDL in atherosclerosis, Free Radic. Biol. Med. 9:155–168.

    Article  PubMed  CAS  Google Scholar 

  • Strehler, B. L., Mark, D. D., Mildvan, A. S., and Gee, M. V., 1959, Rate and magnitude of age pigment accumulation in the human myocardium, J. Gerontol. 14:430–439.

    Article  PubMed  CAS  Google Scholar 

  • Takeuchi, N., Tanaka, E., Katayama, I., Matsumiya, K., and Yamamura, I., 1976, Effects of tocopherol on thiobarbituric acid reactive substances in serum and hepatic subcellular organelles and lipid metabolism, Exp. Gerontol. 11:179–185.

    Article  PubMed  CAS  Google Scholar 

  • Takeuchi, N., Iritani, N., Fukuda, E., and Tanaka, F., 1978, Effects of long-term administration and deficiency of α-tocopherol on lipid metabolism of rats, in Tocopherol, Oxygen and Biomembranes (C. deDuve and O. Hayaishi, eds.), pp. 257–267, Elsevier, Amsterdam.

    Google Scholar 

  • Tappel, A. L., Fletcher, B., and Deamer, D., 1973, Effect of antioxidants and nutrients on lipid peroxidation fluorescent products and aging parameters in the mouse, J. Gerontol. 28:415–424.

    Article  PubMed  CAS  Google Scholar 

  • Thomas, J., and Nyberg, D., 1988, Vitamin E supplementation and intense selection increase clonal life span in Paramecium tetraurelia, Exp. Gerontol. 23:501–512.

    Article  PubMed  CAS  Google Scholar 

  • Tokumaru, S., Iguchi, H., and Kpjo, S., 1996, Changes of the lipid hydroperoxide level in mouse organs on aging, Mech. Ageing Dev. 86:67–74.

    Article  PubMed  CAS  Google Scholar 

  • Tokumaru, S., Ogino, R., Shiromoto, A., Iguchi, H., and Kpjo, S., 1997, Increase of lipid hydroperoxides in tissues of vitamin E-deficient rats, Free Radic. Res. 26:169–174.

    Article  PubMed  CAS  Google Scholar 

  • Tolonen, M., Halme, M., and Sarna, S., 1985, Vitamin E and selenium supplementation in geriatric patients. A double-blind preliminary clinical trial, Biol. Trace Element Res. 7:161–168.

    Article  Google Scholar 

  • Turrens, J. F., Freeman, B. A., and Crapo, J., 1982, Hyperoxia increases H2O2 release by lung mitochondria and microsomes, Arch. Biochem. Biophys. 217:411–421.

    Article  PubMed  CAS  Google Scholar 

  • Upton, A. C., 1977, Pathobiology, in The Biology of Aging (C. H. Finch and L. Hayflick, eds.), pp. 513–535, Van Nostrand, New York.

    Google Scholar 

  • Urano, S., 1993, The role of vitamin E in blood and cellular aging, in Vitamin E in Health and Disease (L. Packer and J. Fuchs, eds.), pp. 159–170, Marcel Dekker, New York.

    Google Scholar 

  • Urano, S., Matsuo, M., Ohtsubo, K., and Izumiyama, N., 1994, Oxidative damage of synaptic membranes in rats during aging, Biomed. Gerontol. 18:378–379.

    Google Scholar 

  • Urano, S., Asai, Y., Makabe, S., Matso, M., Izumiyama, N., Ohtsubo, K., and Endo, T., 1997, Oxidative injury of synapse and antioxidative defense systems in rats, and its prevention by vitamin E, Eur. J. Biochem. 245:67–70.

    Article  Google Scholar 

  • van Kujik, F. J. G. M., Sevanian, A., Handelman, F. J., Dratz, E. D., 1987, A new role for phospholipase A2: Protection of membranes from lipid peroxidation damage, Trends Biochem. Sci. 12:31–34.

    Article  Google Scholar 

  • Verdon-Smith, C., and Enesco, H. E., 1982, The effect of temperature and dietary restriction on life span and reproduction in the rotifer Asplanchna brightwelli, Exp. Gerontol. 17:255–262.

    Article  Google Scholar 

  • Wartanowicz, M., Panczenko-Kresowska, B., Ziemlanski, S., Kowalska, M., and Okolska, G., 1984, The effect of α-tocopherol and ascorbic acid on the serum lipid peroxide level in elderly people, Ann. Nutr. Metab. 28:186–191.

    Article  PubMed  CAS  Google Scholar 

  • Zhang, J.-R., Andrus, P. K., and Hall, E. D., 1994, Age-related phospholipid hydroperoxide levels in gerbil brain measured by HPLC-chemiluminescence and their relation to hydroxyl radical stress, Brain Res. 639:275–282.

    Article  PubMed  CAS  Google Scholar 

  • Zuckerman, B. M. L., and Geist, M. A., 1983, Effect of vitamin E on the nematode Caenorhabditis eleganse, Age 6:1–4.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

Urano, S. (1998). Vitamin E. In: Quinn, P.J., Kagan, V.E. (eds) Fat-Soluble Vitamins. Subcellular Biochemistry, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1789-8_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-1789-8_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1791-1

  • Online ISBN: 978-1-4899-1789-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics