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Mass Spectrometry

Instrumentation and Techniques

  • Chapter
Mass Spectrometry

Part of the book series: Modern Analytical Chemistry ((MOAC))

Abstract

Mass spectrometry (MS) was first used approximately 80 years ago by Sir J. J. Thomson for analysis of positive rays (1). Since then, it has undergone extensive innovations. The last decade has seen an especially rapid pace of development in both instrumentation and ionization techniques. MS is now probably our most versatile and comprehensive analytical tool. It has found applications in several areas of physics, chemistry, biology, medicine, geology, nuclear science, and environmental science. It is used routinely to obtain relative molecular weights (M r) and structural information; to quantify at trace levels; to study ion chemistry and ion-molecule reactions dynamics; to provide data on physical properties such as ionizing energy, appearance energy, the enthalpy of a reaction, and proton affinities; and to verify theoretical predictions based on molecular orbital calculations.

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  1. Charles B. Stout Neuroscience Mass Spectrometry Laboratory, and Department of Neurology, University of Tennessee-Memphis, Memphis, Tennessee, 38163, USA

    Chhabil Dass

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  1. Chhabil Dass
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  1. Departments of Neurology and Biochemistry, and The Charles B. Stout Neuroscience Mass Spectrometry Laboratory, The University of Tennessee, Memphis Memphis, Tennessee, USA

    Dominic M. Desiderio

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Dass, C. (1994). Mass Spectrometry. In: Desiderio, D.M. (eds) Mass Spectrometry. Modern Analytical Chemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1748-5_1

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  • DOI: https://doi.org/10.1007/978-1-4899-1748-5_1

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