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Retroviral cDNA Integration: Mechanism, Applications and Inhibition

  • Chapter
Genetic Engineering

Part of the book series: Genetic Engineering ((GEPM,volume 20))

Abstract

Retroviruses such as human immunodeficiency virus (HIV) are distinguished from other viruses by the combination of two steps in the viral life cycle. The first is reverse transcription, which results in the production of a cDNA copy of the viral RNA genome, and the second is integration, which results in the connection of that cDNA copy to a chromosome of the host. This article centers on the cDNA integration step. Understanding the integration system is important for designing methods for genetic manipulation in animal cells. Integration also represents a key area in developing new anti-retroviral therapy. Furthermore, studies of the integration system shed light on mechanisms in diverse related “mobile DNA” systems. In this article, we focus on recent work in three areas: i) the mechanism of retroviral integration, ii) integration and the development of retroviral vectors and iii) inhibition of integration. For further reviews on retroviral integration see (1–9).

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Author information

Author notes

  1. Christopher Hoffmann

    Present address: School of Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97201, USA

  2. Ling Li

    Present address: Gene Therapy Laboratories, USC School of Medicine, Norris Cancer Center, Los Angeles, CA, 90033, USA

Authors and Affiliations

  1. Infectious Disease Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Mark S. T. Hansen, Sandrine Carteau, Christopher Hoffmann, Ling Li & Frederic Bushman

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  2. Sandrine Carteau
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  3. Christopher Hoffmann
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  4. Ling Li
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  5. Frederic Bushman
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  1. Brookhaven National Laboratory, Upton, New York, USA

    Jane K. Setlow

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Hansen, M.S.T., Carteau, S., Hoffmann, C., Li, L., Bushman, F. (1998). Retroviral cDNA Integration: Mechanism, Applications and Inhibition. In: Setlow, J.K. (eds) Genetic Engineering. Genetic Engineering, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1739-3_3

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