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Molecular Engineering of Monoterpene Production

  • Chapter
Genetic Engineering

Part of the book series: Genetic Engineering ((GEPM,volume 20))

Abstract

The terpenoids (often referred to as isoprenoids) constitute the largest group of natural products, with more than 22, 000 individual structures now known (1). They are all derived from the sequential addition of branched, five-carbon isopentenoid (isoprenoid) units, and range in size from isoprene (C5H8) to natural rubber (molecular weight greater than 106). In plants, the terpenoids and meroterpenoids (in which the terpenoid comprises a part of a larger molecule) play a broad range of metabolic and physiological roles, for example in photosynthesis (chlorophyll side chains, carotenoids, phylloquinones, plastoquinones), respiration (ubiquinone), cell membrane architecture (sterols), regulation of growth and development (gibberellins, abscisic acid, brassinosteroids), defense mechanisms (as phytoalexins, insect feeding and oviposition deterrents, competitive phytotoxins), and reproduction (as attractants of pollinators and seed dispersing animals). Additionally, isoprenylation of proteins by addition of a C15 or C20 olefinic chain provides a means of membrane anchoring, for example of cell cycle-regulating proteins. In this chapter, we focus on one family of industrially and agronomically significant plant terpenoids, the monoterpenes, and on the potential for the molecular genetic manipulation of the biosynthesis of this group of C10 compounds formed by the head-to-tail condensation of two isoprenoid units.

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Author information

Authors and Affiliations

  1. Institute of Biological Chemistry, Washington State University, Pullman, WA, 99164-6340, USA

    Christian D. Haudenschild & Rodney B. Croteau

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  1. Christian D. Haudenschild
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  2. Rodney B. Croteau
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Editors and Affiliations

  1. Brookhaven National Laboratory, Upton, New York, USA

    Jane K. Setlow

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Haudenschild, C.D., Croteau, R.B. (1998). Molecular Engineering of Monoterpene Production. In: Setlow, J.K. (eds) Genetic Engineering. Genetic Engineering, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1739-3_14

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  • DOI: https://doi.org/10.1007/978-1-4899-1739-3_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1741-6

  • Online ISBN: 978-1-4899-1739-3

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