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Biochemistry and Pathophysiology of the Molecular Forms of Cholinesterases

  • Zoltán Rakonczay
  • Stephen Brimijoin
Part of the Subcellular Biochemistry book series (SCBI, volume 12)

Abstract

Acetylcholinesterase (acetylcholine acetylhydrolase, AChE: EC 3.1.1.7) and butyrylcholinesterase (acylcholine acylhydrolase, BuChE: EC 3.1.1.8) both possess the capacity to hydrolyze choline esters, although the latter accepts a much wider variety of substrates. These two enzymes are found in a large number of excitable and nonexcitable tissues in most species, including humans (for review see Silver, 1974). The two types of ChE (generic abbreviation for any Cholinesterase) are readily distinguished not only by their substrate specificity but also by their response to selective inhibitors.

Keywords

Amyotrophic Lateral Sclerosis Amniotic Fluid AChE Activity Molecular Form Extensor Digitorum Longus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used in this chapter

AChE

acetylcholinesterase

AD

Alzheimer’s disease

ALS

amyotrophic lateral sclerosis

BuChE

butyrylcholinesterase

cDNA

complementary DNA

ChAT

choline acetyltransferase

ChE

Cholinesterase

CSF

cerebrospinal fluid

EDL

extensor digitorum longus

FACS

fluorescence-activated cell sorter

McAb

monoclonal antibody

mdg

muscular dysgenesis

med

motor endplate disease

NTD

neural tube defects

PNH

paroxysmal nocturnal hemoglobinuria

PTA

phenyltrimethylammonium

RBC

red blood cell

SCG

superior cervical ganglion.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Zoltán Rakonczay
    • 1
  • Stephen Brimijoin
    • 2
  1. 1.Central Research LaboratoryMedical UniversitySzegedHungary
  2. 2.Department of PharmacologyMayo ClinicRochesterUSA

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