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Breast-Cancer-Associated Antigens Defined by Monoclonal Antibodies

  • Chapter
Immunological Aspects

Part of the book series: Subcellular Biochemistry ((SCBI,volume 12))

Abstract

The development of monoclonal antibodies against malignant cells is projected to have a number of significant applications related to the clinical management of breast cancer. These include the early diagnosis of tumors, monitoring patients for the detection of recurrence or effects of therapy, and therapeutic modalities, whereby antibodies are employed to target cytotoxic agents (drugs, toxins, or radionuclides) to the site of the tumor. Since in Western countries, breast cancer will afflict in the region of one out of every 14 women, it is essential that the potential of these agents should be explored fully. Conventional wisdom indicates that aids to earlier diagnoses would have an important impact on prognosis. Present methods of diagnosis by palpation and mammography permit detection of tumor masses with diameters as small as 1 cm. However, even at this apparently early stage, tumors may be sufficiently established for the dissemination of tumor cells to have already occurred (reviewed by Tagnon, 1986). Thus, if breast cancer is only rarely a localized disease when it is clinically evident, there is clearly a need for assays that might provide earlier, accurate diagnoses and that reflect tumor burden. Given the sensitivity and specificity that can be obtained with monoclonal antibodies, their use in immunoassays offers the possibilities for the measurement of these clinical parameters and for optimizing therapy.

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  1. Cancer Research Campaign Laboratories, University of Nottingham, University Park, Nottingham, NG7 2RD, UK

    Michael R. Price

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  1. North East Thames Regional Transfusion Centre, Brentwood, Essex, England

    J. R. Harris

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Price, M.R. (1988). Breast-Cancer-Associated Antigens Defined by Monoclonal Antibodies. In: Harris, J.R. (eds) Immunological Aspects. Subcellular Biochemistry, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1681-5_1

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  • DOI: https://doi.org/10.1007/978-1-4899-1681-5_1

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