Effects of Abstinence from Tobacco

A Critical Review
  • John R. Hughes
  • Stephen T. Higgins
  • Dorothy Hatsukami


Many smokers, ex-smokers, and scientists have strong opinions about the effects of abstinence from tobacco. Some believe the effects are mild, are not true withdrawal phenomena, and have little to do with the inability of smokers to stop. Others believe abstinence effects can produce significant distress, are similar to the classical withdrawal syndromes of opiates and sedatives, and account for much of the inability of smokers to stop.


Smoking Cessation Withdrawal Syndrome Rebound Effect Smokeless Tobacco Nicotine Withdrawal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Abrams, P., Monte, P., Pinto, R., Elder, J., and Brown, P., 1987, Psychosocial stress and coping in smokers who relapse or quit, Health Psychol. 6:289–303.PubMedCrossRefGoogle Scholar
  2. Ague, C., 1974, Cardiovascular variables, skin conductance and time estimation: Changes after the administration of small doses of nicotine, Psychopharmacology 37:109–125.CrossRefGoogle Scholar
  3. Albanes, D., Jones, Y., Micuzzi, M. S., and Mattson, M. E., 1987, Associations between smoking and and body weight in the U.S. population: Analysis of NHANES I, Am. J. Public Health 77:439–444.PubMedCrossRefGoogle Scholar
  4. American Psychiatric Association, 1980, Diagnostic and Statistical Manual, 3rd ed., pp. 159–160, 176–178, American Psychiatric Association, Washington, DC.Google Scholar
  5. American Psychiatric Association, 1987, Diagnostic and Statistical Manual, 3rd ed.—revised, pp. 150–151, 166–168, 181–182, American Psychiatric Association, Washington, DC.Google Scholar
  6. Ashton, H., and Stepney, R., 1982, Smoking: Psychology and Pharmacology, Tavistock, New York.Google Scholar
  7. Axelsson, A., and Brantmark, B., 1975, The anti-smoking effect of chewing gum with nicotine of high and low bioavailability, in: Proceedings of the Third World Conference on Smoking and Health, American Cancer Society, New York.Google Scholar
  8. Azrin, H. H., Hutchinson, R. R., and Hake, D. F., 1966, Extinction-induced aggression, J. Exp. Anal. Behav. 9:191–204.PubMedCrossRefGoogle Scholar
  9. Bachynsky, N., 1986, The case for anticholinergic drugs for smoking cessation: A pilot study, Int. J. Addict. 21:789–805.PubMedGoogle Scholar
  10. Badawy, A. A.-B., and Evans, M., 1973, The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptophan pyrolase and their resemblance to those of ethanol, Biochem. J. 135:555–557.PubMedGoogle Scholar
  11. Badawy, A. A.-B., and Evans, M., 1974, The effects of ethanol on tryptophan pyrolase activity and their comparison with those of phenobarbitone and morphine, Adv. Exp. Med. Biol. 59:229–251.Google Scholar
  12. Badawy, A. A.-B., and Evans, M., 1975a, The effects of acute and chronic nicotine hydrogen (+)— tartrate administration and subsequent withdrawal on rat liver tryptophan pyrrolase activity and their comparison with those of morphine, phenobarbitone, and ethanol, Biochem. J. 148:425–432.PubMedGoogle Scholar
  13. Badawy, A. A.-B., and Evans, M., 1975b, The effects of ethanol on tryptophan pyrrolase activity and their comparison with those of phenobarbitone and morphine, Adv. Exp. Med. Biol. 59:229–251.PubMedGoogle Scholar
  14. Badawy, A. A.-B., and Evans, M., 1983, Opposite effects of chronic administration and subsequent withdrawal of drugs of dependence on the metabolism and disposition of endogenous and exogenous tryptophan in the rat, Alcohol Alcoholism 18:369–382.Google Scholar
  15. Badawy, A. A.-B., Punjani, N. F., and Evans, M., 1980a, The effects of ethanol on rat liver and brain tryptophan metabolism, Substance Alcohol Actions/Misuse 1:507–515.Google Scholar
  16. Badawy, A. A.-B., Punjani, N. F., Evans, C. M., and Evans, M., 1980b, Inhibition of rat brain tryptophan metabolism by ethanol withdrawal and possible involvement of the enhanced liver trypophan pyrrolase activity, Biochem. J. 192:449–455.PubMedGoogle Scholar
  17. Badawy, A. A.-B., Evans, M., and Punjani, N. F., 1981a, Reversal by naloxone of the effects of chronic administration of drugs of dependence on rat liver and brain tryptophan metabolism, Br. J. Pharmacol. 74:489–494.PubMedCrossRefGoogle Scholar
  18. Badawy, A. A.-B., Punjani, N., and Evans, M., 1981b, The role of liver tryptophan pyrolase in the opposite effects of chronic administration and subsequent withdrawal of drugs of dependence on rat brain tryptophan metabolism, Biochem. J. 196:161–170.PubMedGoogle Scholar
  19. Balfour, D. J., 1980, Studies on biochemical and behavioral effects of oral nicotine, Arch. Int. Pharmacodyn. 245:95–103.PubMedGoogle Scholar
  20. Balfour, D. J., 1982, The pharmacology of nicotine dependence: A working hypothesis, Pharmacol. Ther. 15:239–250.CrossRefGoogle Scholar
  21. Balfour, D. J., and Benwell, M. E., 1981, The effects of chronic nicotine administration and withdrawal on 5-hydroxtryptamine synthesis and uptake by rat brain synaptosomes, Br. J. Pharmacol. 72:490.Google Scholar
  22. Balfour, D. J., and Morrison, C.F., 1975, A possible role for the pituitary-adrenal system in the effects of nicotine on avoidance behavior, Pharmacol. Biochem. Behav. 3:349–354.PubMedCrossRefGoogle Scholar
  23. Balster, R. L., 1985, Behavioral studies of tolerance and dependence, in: Behavioral Pharmacology: The Current Status, Neurology and Neurobiology, Volume 13 (L. Seiden, and R. L. Balster, eds.), pp. 403–418, Alan R. Liss, New York.Google Scholar
  24. Benowitz, N. L., Kuyt, F., and Jacob, P., 1984, Influence of nicotine on cardiovascular and hormonal effects of cigarette smoking, Clin. Pharmacol. Ther. 36:74–81.PubMedCrossRefGoogle Scholar
  25. Benowitz, N. L., Hall, S. M., and Moden, G. M., 1988, Caffeine levels and consumption following tobacco abstinence: Evidence for caffeine regulation, Unpublished manuscript.Google Scholar
  26. Benwell, M. E., and Balfour, D. J., 1979, Effects of nicotine administration and its withdrawal on plasma corticosterone and brain 5-hydroxyindoles, Psychopharmacology 63:7–11.PubMedCrossRefGoogle Scholar
  27. Benwell, M. E., and Balfour, D. J., 1982, Effects of chronic nicotine administration on the response and adaptation to stress, Psychopharmacology 76:160–162.PubMedCrossRefGoogle Scholar
  28. Benwell, M. E., Balfour, D. J., and Anderson, J. M., 1988, Evidence that tobacco smoking increases the density of (-)[3H] nicotine binding sites in human brain, J. Neurochem. 50:1243–1247.PubMedCrossRefGoogle Scholar
  29. Bickel, W. K., Stitzer, M. L., Liebson, I. A., and Bigelow, G. E., 1988, Acute physical dependence in man: Effects of naloxone after acute morphine exposure, J. Pharmacol. Exp. Ther. 244:126–132.PubMedGoogle Scholar
  30. Black, P. M., Giovino, G. A., Ossip-Klein, D. J., Megahead, N., Reynolds, W., Lent, L., DeBole, N., Valenzuela, L., Leone, M. A., and Stiggins, J., November 1988. Weight gain following smoking cessation in a self-help population: An exploratory analysis, Presented at the Annual Meeting of the Association for the Advancement of Behavior Therapy, Boston.Google Scholar
  31. Bojholm, S., Hansen, M., Meyer, J., Andersen, B. T., and Gyntelberg, F., 1980, Effect of smoking cessation on heart rate and blood pressure at rest and during exercise, Danish Med. Bull. 27:96–98.PubMedGoogle Scholar
  32. Bosse, R., Garvey, A. J., and Costa, P. T., 1980, Predictors of weight change following smoking cessation, Int. J. Addict. 15:969–991.PubMedGoogle Scholar
  33. Bourne, S., 1985, Treatment of cigarette smoking with short-term high-dosage corticotrophin therapy: Preliminary communication, J. Roy. Soc. Med. 78:649–650.PubMedGoogle Scholar
  34. Bowen, D. J., Evry, S. E., and Grunberg, N. E., 1986, Nicotine’s effects on female rats’ body weight: Caloric intake and physical activity, Pharmacol. Biochem. Behav. 25:1131–1136.PubMedCrossRefGoogle Scholar
  35. Brady, J. V., and Lukas, S. E., eds., 1984, Testing Drugs for Physical Dependence Potential and Abuse Liability, NIDA Research Monograph 52, U.S. Govt. Printing Office, Washington, DC.Google Scholar
  36. Brantmark, B., Ohlin, P., and Westling, H., 1973, Nicotine-containing chewing gum as an anti-smoking aid, Psychopharmacology 31:191–200.CrossRefGoogle Scholar
  37. Brown, B. B., 1968, Some characteristic EEG differences between heavy smoker and non-smoker subjects, Neuropsychiatry 6:381–388.Google Scholar
  38. Brown, C. R., Jacob, P., Wilson, M., and Benowitz, N. L., 1988, Changes in rate and pattern of caffeine metabolism after cigarette abstinence, Clin. Pharmacol. Ther. 43:488–491.PubMedCrossRefGoogle Scholar
  39. Brozek, J., and Keys, A., 1957, Changes of body weight in normal men who stop smoking cigarettes, Science 125:1203.PubMedCrossRefGoogle Scholar
  40. Burse, R. L., Bynum, G. D., Pandolf, K. B., Goldman, R. F., Sims, E. A., and Danforth, E. R., 1975, Increased appetite and unchanged metabolism upon cessation of smoking with diet held constant, Physiologist 18:157.Google Scholar
  41. Burse, R. L., Goldman, R. F., Danforth, E., Horton, E. S., and Sims, E. A., 1976, Effects of cigarette smoking on body weight, energy expenditure, appetite, and endocrine function, Unpublished manuscript.Google Scholar
  42. Cambien, F., Richard, J. L., Ducimetiere, P., Warnet, J. M., and Kahn, J., 1981. The Paris Cardiovascular Risk Factor Prevention Trial: Effects of two years of intervention in a population of young men, J. Epidemiol. Comm. Health 35:91–97.CrossRefGoogle Scholar
  43. Cappell, H., and Leblanc, A. E., 1971, Tolerance and physical dependence. Do they play a role in alcohol and drug self-administration? in: Research Advances in Alcohol and Drug Abuse, Volume 6 (Y. Israel, F. B. Glaser, H. Kalant, R. E. Popham, W. Schmidt, and R. G. Smart, eds.), pp. 159–196, Plenum Press, New York.Google Scholar
  44. Carney, R. M., and Goldberg, A. P., 1984, Weight gain after cessation of cigarette smoking, N. Engl. J. Med. 310:614–616.PubMedCrossRefGoogle Scholar
  45. Carroll, M. E., and Meisch, R. A., 1984, Increased drug-reinforced behavior due to food deprivation, in: Advances in Behavioral Pharmacology, Volume 4 (T. Thompson, P. B. Dews, and J. E. Barrett, eds.), pp. 47–88, Academic Press, New York.Google Scholar
  46. Cherek, D. R., 1981, Effects of smoking different doses of nicotine on human aggressive behavior, Psychopharmacology 75:334–345.CrossRefGoogle Scholar
  47. Cherry, N., and Kiernan, K., 1976, Personality scores and smoking behavior: A longitudinal study, Br. J. Prev. Soc. Med. 30:123–131.PubMedGoogle Scholar
  48. Clarke, P. B., and Kumar, R., 1983, The effects of nicotine on locomotor activity in nontolerant and tolerant rats, Br. J. Pharmacol. 78:329–337.PubMedCrossRefGoogle Scholar
  49. Clarke, P. B., and Kumar, R., 1984, Some effects of nicotine on food and water intake in undeprived rats, Br. J. Pharmacol. 82:233–239.PubMedCrossRefGoogle Scholar
  50. Classen, W., and Battig, K., 1976, Nicotine induced changes in the regulation of body weight in growing rats, Sozial-praventivmed., Med. Soc. E Prev. 21:142–143.CrossRefGoogle Scholar
  51. Clearman, D. R., and Jacobs, D. R., 1985, Relationships between weight and caloric intake of men who stop smoking, Unpublished manuscript.Google Scholar
  52. Comstock, G. W., and Stone, R. W., 1972, Changes in body weight and subcutaneous fatness related to smoking habits, Arch. Environ. Health 24:271–276.PubMedCrossRefGoogle Scholar
  53. Crabbe, J. C., and Belknap, J. K., 1980, Pharmacogenetic tools in the study of drug tolerance and dependence, Substance Alcohol Actions/Misuse 1:385–413.Google Scholar
  54. Cryer, P. E., Haymond, M. W., Santiago, J. V., and Shad, S. D., 1976, Norepinephrine and epinephrine release and adrenergic mechanism of smoking-associable hemodynamic and metabolic events, N. Engl. J. Med. 295:573–577.PubMedCrossRefGoogle Scholar
  55. Cummings, K. M., Jaen, C.R., and Giovino, G., 1985a, Circumstances surrounding relapse in a group of recent ex-smokers, Prev. Med. 14:195–202.PubMedCrossRefGoogle Scholar
  56. Cummings, K. M., Giovino, G., Jaen, C.R., and Emrich, L. J., 1985b, Reports of smoking withdrawal symptoms over a 21-day period of abstinence, Addict. Behav. 10:373–381.PubMedCrossRefGoogle Scholar
  57. Cushman, P., Forbes, R., Lerner, W., and Stewart, M., 1985, Alcohol withdrawal syndromes: Chemical management with lofexidine, Alcoholism Clin. Exp. Res. 9:103–108.CrossRefGoogle Scholar
  58. Dahlstrom, A., Booj, S., Heiwall, P. O., and Larsson, P. A., 1980, The effect of chronic nicotine and withdrawal on intra-neuronal dynamics of acetylcholine and related enzymes in a preganglionic neuron system of the rat, Acta Physiol. Scand. 110:13–20.PubMedCrossRefGoogle Scholar
  59. Dalloso, H. M., and James, W. P. T., 1983, The role of smoking in the regulation of energy balance, Int. J. Obesity 8:365–375.Google Scholar
  60. Dawson, G. W., and Vestal, R. E., 1982, Smoking and drug metabolism, Pharmacol. Ther. 15:207–221.CrossRefGoogle Scholar
  61. Dews, P. B., and Wenger, G. R., 1977, Rate dependency of the behavioral effects of amphetamine, in: Advances in Behavioral Pharmacology, Volume 1 (T. Thompson and P. B. Dews, eds.), pp. 167 – 227, Academic Press, New York.Google Scholar
  62. Dow, R. J., and Fee, W. M., 1984, Use of beta-blocking agents with group therapy in a smoking withdrawal clinic, J. Roy. Soc. Med. 77:648–651.PubMedGoogle Scholar
  63. Duffy, J., and Hall, S. M., in press, Smoking abstinence, eating style, and food intake, J. Consult. Clin. Psychol. Google Scholar
  64. Edwards, G., Arif, A., and Hodgson, R., 1981, Nomenclature and classification of drug and alcohol related problems: A WHO memorandum, Bull. WHO 59:225–242.PubMedGoogle Scholar
  65. Edwards, J., and Warburton, D., 1983, Smoking, nicotine and electrocortical activity, Pharmacol. Ther. 19:147–164.CrossRefGoogle Scholar
  66. Edwards, N. B., Simmons, R. C., Rosenthal, T. L., Hoon, P. W., and Downs, J. M., 1988, Doxepin in the treatment of nicotine withdrawal, Psychosomatic s 29:203–206.CrossRefGoogle Scholar
  67. Eisenberg, R. M., and Sparber, S. B., 1979, Changes in plasma corticosterone level as a measure of acute dependence upon levorphenol in rats, J. Pharmacol. Exp. Ther. 211:364–369.PubMedGoogle Scholar
  68. Eiser, J., Van der Plight, J., Raw, M., and Sutton, S., 1985, Trying to stop smoking: Effects of perceived addiction, attributions for failure, and expectancy for success, J. Behav. Med. 8:321–341.PubMedCrossRefGoogle Scholar
  69. Eldon, M. A., Lerecker, P. W., MacGee, J., and Ritschel, W. A., 1987, Lack of effect of withdrawal from cigarette smoking on theophylline pharmacokinetics, J. Clin. Pharmacokin. 27:221–225.CrossRefGoogle Scholar
  70. Elgerot, A., 1976, Note on selective effects of short-term tobacco abstinence on complex versus simple mental tasks, Percept. Motor Skills 42:413–414.PubMedCrossRefGoogle Scholar
  71. Elgerot, A., 1978, Psychological and physiological changes during tobacco: Abstinence in habitual smokers, J. Clin. Psychol. 34:759–764.PubMedCrossRefGoogle Scholar
  72. Emont, S. L., and Cummings, K. M., 1987, Weight gain following smoking cessation: A possible role for nicotine replacement in weight management, Addict. Behav. 12:151–155.PubMedCrossRefGoogle Scholar
  73. Eysenk, J. H., and Eaves, E. J., 1980, The Causes and Effects of Smoking, Maurice Temple Smith, London.Google Scholar
  74. Eysenk, J. H., and Eysenk, S. B. G., 1975, Manual of the Eysenk Personality Questionnaire, Hodder and Stoughton, London.Google Scholar
  75. Fagerstrom, K. O., 1978, Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment, Addict. Behav. 3:235–241.PubMedCrossRefGoogle Scholar
  76. Fagerstrom, K. O., 1980, Physical dependence on nicotine as a determinant of success in smoking cessation, World Smoking Health 5:22–23.Google Scholar
  77. Fagerstrom, K. O., 1987, Reducing the weight gain after stopping smoking, Addict. Behav. 12:91–93.PubMedCrossRefGoogle Scholar
  78. Falk, J. L., 1981, The environmental generation of excessive behavior, in: Behavior in Excess: An Examination of the Volitional Disorders (S. J. Mule, ed.), pp. 313–337, Free Press, London.Google Scholar
  79. Falk, J. L., 1983, Drug dependence: Myth or motive? Pharmacol. Biochem. Behav. 19:385–391.PubMedCrossRefGoogle Scholar
  80. Falkenborn, Y., Larsson, C., and Nordberg, A., 1981, Chronic nicotine exposure in the rat: A behavioral and biochemical study of tolerance, Drug Alcohol Depend. 8:51–60.CrossRefGoogle Scholar
  81. Fehily, A. M., Phillips, K. M., and Yarnell, J. W. G., 1984, Diet, smoking, social class and body mass index in the Caerphilly Heart Disease Study, Am. J. Clin. Nutr. 40:827–833.PubMedGoogle Scholar
  82. Feldman, R. S., and Quenzer, L. F., 1984, Fundamentals of Neuropsychopharmacology, pp. 237–258, Sinauer, Sunderland, MA.Google Scholar
  83. Fertig, J. B., Pomerleau, O. F., and Sanders, B., 1986, Nicotine-produced antinociception in minimally deprived smokers and ex-smokers, Addict. Behav. 11:239–248.PubMedCrossRefGoogle Scholar
  84. Finnegan, J. K., Larson, P. S., and Haag, H. B., 1945, The role of nicotine in the cigarette habit, Science 10:294–96.Google Scholar
  85. Finnegan, L. P., 1981, Maternal and neonatal effects of drug dependence in pregnancy, in: Substance Abuse: Clinical Problems and Perspectives (J. H. Lowinson and P. Renz, eds.), pp. 545–581, Williams & Wilkins, Baltimore.Google Scholar
  86. Fixx, A. J., Daughton, D., Kass, I., Smith, J. L., Wickiser, A., and Golden, C. J., in press, Urinary alkanization and smoking cessation, J. Clin. Psychol. Google Scholar
  87. Flanagan, J., and Maany, I., 1982, Smoking and depression, Am. J. Psychiatry 139:541.PubMedGoogle Scholar
  88. Frankenhaeuser, M., 1971, Behavior and circulating catecholamines, Brain Res. 34:241–262.CrossRefGoogle Scholar
  89. Freidman, G. D., and Siegelaub, A. B., 1980, Changes after quitting cigarette smoking, Circulation 61: 716–723.CrossRefGoogle Scholar
  90. Freidman, J., Horvath, T., and Meares, R., 1974, Tobacco smoking and a “stimulus barrier,” Nature 248:455–456.CrossRefGoogle Scholar
  91. Fuller, J. A., 1982, Smoking withdrawal and acupuncture, Med. J. Aust. 1:28–29.PubMedGoogle Scholar
  92. Garvey, A., Bosse, R., and Seltzer, C., 1974, Smoking, weight change, and age, Arch. Environ. Health 28:327–329.PubMedCrossRefGoogle Scholar
  93. Gilbert, D., 1979, Paradoxical tranquilizing and emotion reducing effects of nicotine, Psychol. Bull. 86: 643–661.PubMedCrossRefGoogle Scholar
  94. Gilbert, R. M., and Pope, M. A., 1982, Early effects of quitting smoking, Psychopharmacology 78: 121–127.PubMedCrossRefGoogle Scholar
  95. Glassman, A. H., Jackson, W. K., Walsh, B. T., and Roose, S. P., 1985, Cigarette craving, smoking withdrawal, and Clonidine, Science 226:864–866.CrossRefGoogle Scholar
  96. Glassman, A. H., Stetner, F., Walsh, B. T., Raizman, P. S., Fleess, I. L., Cooper, T. B., and Corey, L. S., 1988, Heavy smokers, smoking cessation and Clonidine, J. Am. Med. Ass. 259:2863–2866.CrossRefGoogle Scholar
  97. Glauser, S. C., Glauser, E. M., Reidenberg, M. M., Rusy, B. F., and Tallarida, R. J., 1970, Metabolic changes associated with the cessation of cigarette smoking, Arch. Environ. Health 20:377–381.PubMedCrossRefGoogle Scholar
  98. Glynn, S. M., Grader, C. L., and Jegerski, J. A., 1986, Effects of biochemical validation of self-reported cigarette smoking on treatment success and on misreporting abstinence, Health Psychol. 5: 125–136.PubMedCrossRefGoogle Scholar
  99. Goldberg, S. R., and Stolerman, I. P., eds., 1986, Behavioral Analysis of Drug Dependence, Academic Press, New York.Google Scholar
  100. Goldstein, A., 1987, Criteria of a pharmacologic withdrawal syndrome, Arch. Gen. Psychiatry 44:392.PubMedCrossRefGoogle Scholar
  101. Goldstein, M. G., Ward, K., and Niaura, R., May 1988, Nicotine gum, tobacco dependence and withdrawal, Presented at the Annual Meeting of the American Psychiatric Association, Montreal.Google Scholar
  102. Gordon, T., Kannel, W. B., Dawber, T. R., and McGee, D., 1975, Changes associated with quitting cigarette smoking: The Framingham study, Am. Health J. 90:322–328.Google Scholar
  103. Gorelick, D. A., Rose, J., and Jarvik, M. E., 1988, Effect of naloxone on cigarette smoking, J. Substance Abuse 1:153–159.CrossRefGoogle Scholar
  104. Gottlieb, A. M., Killen, J. D., Marlatt, G. A., and Taylor, C. B., 1987, Psychological and pharmacological influences in cigarette smoking withdrawal: The effects of nicotine gum and expectancy on smoking withdrawal symptoms and relapse, J. Consult. Clin. Psychol. 55:606–608.PubMedCrossRefGoogle Scholar
  105. Griffiths, R. R., and Balster, R. L., 1979, Opioids: Similarity between evaluations of subjective effects and animal self-administration results, Clin. Pharmacol. Ther. 25:611–617.PubMedGoogle Scholar
  106. Griffiths, R. R., and Woodson, P. P., 1988, Caffeine physical dependence: A review of human, laboratory and animal studies, Psychopharmacology 94:437–451.PubMedCrossRefGoogle Scholar
  107. Grinstead, O. A., 1981, Preventing weight gain following smoking cessation: A comparison of behavioral treatment approaches, Univ. Microfilms Int. 82– 06024:174.Google Scholar
  108. Gritz, E. R., 1980, Smoking behavior and tobacco abuse, in: Advances in Substance Abuse, Volume 1 (N. Mello, ed.), pp. 91–158, JAI Press, Greenwich, CT.Google Scholar
  109. Gritz, E. R., and Jarvik, M. E., 1973, Preliminary study: Forty-eight hours of abstinence from smoking, in: Proceedings of the 81st Annual Convention, American Psychological Association, pp. 1039–1040, American Psychological Association, Washington, DC.Google Scholar
  110. Grunberg, N. E., 1982, The effects of nicotine and cigarette smoking on food consumption and taste preferences, Addict. Behav. 7:317–331.PubMedCrossRefGoogle Scholar
  111. Grunberg, N. E., 1985, Nicotine, cigarette smoking and body weight, Br. J. Addict. 80:369–377.PubMedCrossRefGoogle Scholar
  112. Grunberg, N. E., 1986, Behavioral and biological factors in the relationship between tobacco use and body weight, in: Advances in Behavioral Medicine (E. S. Katkin and S. B. Manien, eds.), pp. 97–129, JAI Press, Greenwich, CT.Google Scholar
  113. Grunberg, N. E., and Bowen, D. J., 1985, The role of physical activity in nicotine’s effects on body weight, Pharmacol. Biochem. Behav. 23:851–854.PubMedCrossRefGoogle Scholar
  114. Grunberg, N. E., Bowen, D. J., and Morse, D. E., 1984, Effects of nicotine on body weight and food consumption in rats, Psychopharmacology 83:93–98.PubMedCrossRefGoogle Scholar
  115. Grunberg, N. E., Bowen, D. J., Maycock, V. A., and Nespor, S. M., 1985, The importance of sweet taste and caloric content in the effects of nicotine on specific food consumption, Psychopharmacology 87:198–203.PubMedCrossRefGoogle Scholar
  116. Grunberg, N. E., Bowen, D. J., and Winders, S. E., 1986, Effects of nicotine on body weight and food consumption in female rats, Psychopharmacology 90:101–105.PubMedCrossRefGoogle Scholar
  117. Grunberg, N. E., Winders, S. E., and Popp, K. A., 1987, Sex differences in nicotine’s effects on consumatory behavior and body weight in rats, Psychopharmacology 91:221–225.PubMedCrossRefGoogle Scholar
  118. Grunberg, N. E., Popp, K. A., and Winders, S. E., 1988a, Effects of nicotine on body weight in rats with access to “junk” foods, Psychopharmacology 94:536–539.PubMedCrossRefGoogle Scholar
  119. Grunberg, N. E., Nespor, S. M., Popp, K. A., Raygada, M., Sibolboro, E. C., Winders, S. E., August 1988b, Nicotine cessation affects plasma insulin and glucose levels in rats, Presented at the Annual Meeting of the American Psychological Association, New York.Google Scholar
  120. Guilford, J. S., 1966, Factors Related to Successful Abstinence from Smoking, American Institute for Research, Pittsburgh.Google Scholar
  121. Guilford, J. S., 1967, Sex differences between successful and unsuccessful abstainers from smoking, in: Studies and Issues in Smoking Behavior (S. V. Zagona, ed.), pp. 95–102, University of Arizona Press, Tucson.Google Scholar
  122. Gunn, R. C., 1986, Reactions to withdrawal symptoms and success in smoking cessation clinics, Addict. Behav. 11:49–53.PubMedCrossRefGoogle Scholar
  123. Gunn, R. C., and Shapiro, A., 1979, Life stress, weight gain and resuming smoking after success in a cessation clinic, Psychol. Rep. 57:1035–1039.CrossRefGoogle Scholar
  124. Gust, S. W., Hughes, J. R., and Keenan, R., June 1985, A randomized, placebo-controlled study of the effects of dose on nicotine gum self-administration, Presented at the Annual Meeting of the International Study Group Investigating Drugs As Reinforcers, Baltimore.Google Scholar
  125. Hall, G. H., 1982, Pharmacological responses to the intracerebral administration of nicotine, Pharmacol. Ther. 15:223–238.CrossRefGoogle Scholar
  126. Hall, G. H., and Morrison, C.F., 1973, New evidence for a relationship between tobacco smoking, nicotine dependence and stress, Nature 243:199–201.PubMedCrossRefGoogle Scholar
  127. Hall, R. A., Rappaport, M., Hopkins, H., and Griffin, R., 1973, Tobacco and evoked potential, Science 180:212–214.PubMedCrossRefGoogle Scholar
  128. Hall, S. M., 1984, The abstinence phobias: Links between substance abuse and anxiety, Int. J. Addict. 19:613–631.PubMedGoogle Scholar
  129. Hall, S. M., Ginsberg, D., and Jones, R. T., 1986, Smoking cessation and weight gain, J. Consult. Clin. Psychol. 54:342–346.PubMedCrossRefGoogle Scholar
  130. Harris, C. M., Emmett-Oglesby, M. W., Robinson, N. G., and Lal, H., 1986a, Withdrawal from chronic nicotine substitutes partially for the interoceptive stimulus produced by pentylenetetrazol, Psychopharmacology 90:85–89.PubMedCrossRefGoogle Scholar
  131. Harris, C. M., Emmett-Oglesby, M. W., Robinson, N. G., and Lal, H., 1986b, Subjective effects of nicotine withdrawal: Evidence for role of GABAergic system, J. Am. Osteopathic. Assoc. 86 (689): 103–104.Google Scholar
  132. Harris, C. M., Elkhayat, I. S., Bhadra, S., Wood, D., and Lal, H., June 1988, Comparison of pentylenetetrazol-like withdrawal stimulus after chronic treatment with amphetamine, nicotine and cocaine, Presented at the Internation Meeting of the Society for Stimulus Properties of Drugs, Falmouth, MA.Google Scholar
  133. Hasselmeyer, E. G., Meyer, M. B., Longo, L. D., and Mattison, D. R., 1983, Pregnancy and infant health, in: The Health Consequences of Smoking for Women: A Report of the Surgeon General, pp. 189–250, U.S. Government Printing Office, Washington, DC.Google Scholar
  134. Hatsukami, D. K., 1988, Nicotine: Withdrawal reactions (physical dependence) in: The Health Consequences of Smoking: Nicotine Addiction (N. L. Benowitz, N. E. Grunberg, J. E. Henningfield, and H. A. Lando, eds.), pp. 197–211, U.S. Government Printing Office, Washington, DC.Google Scholar
  135. Hatsukami, D. K., and Hughes, J. R., 1985, Characterization of tobacco withdrawal: Physiological and subjective effects, in: Pharmacological Adjuncts in Smoking Cessation, NIDA Research Monograph No. 53 (J. Grabowski and S. M. Hall, eds.), pp. 56–67, U.S. Government Printing Office, Washington, DC.Google Scholar
  136. Hatsukami, D. K., Hughes, J. R., Pickens, R. W., and Svikis, D. S., 1984, Tobacco withdrawal symptoms: An experimental analysis, Psychopharmacology 84:231–236.PubMedCrossRefGoogle Scholar
  137. Hatsukami, D. K., Hughes, J. R., and Pickens, R. W., 1985, Blood nicotine, smoke exposure and tobacco withdrawal symptoms, Addict. Behav. 10:413–417.PubMedCrossRefGoogle Scholar
  138. Hatsukami, D. K., Gust, S. W., and Keenan, R., 1987, Physiological and subjective changes from smokeless tobacco withdrawal, Clin. Pharmacol. Ther. 41:103–107.PubMedCrossRefGoogle Scholar
  139. Hatsukami, D. K., Dalgren, L., and Hughes, J. R., 1988, Symptoms of tobacco withdrawal from abrupt cigarette cessation versus partial cigarette reduction, Psychopharmacology 94:242–247.PubMedCrossRefGoogle Scholar
  140. Hatsukami, D., Morgan, S. F., Pickens, R. W., and Hughes, J. R., 1987, Smoking topography in a nonlaboratory environment, Int. J. Addict. 22:719–725.PubMedGoogle Scholar
  141. Heimstra, N. W., Bancroft, N. R., and DeKock, A. R., 1967, Effects of smoking upon sustained performance in a simulated driving task, Ann. NY Acad. Sci. 142:295–307.CrossRefGoogle Scholar
  142. Henningfield, J. E., Miyasato, K., and Jasinski, D. R., 1985, Abuse liability and pharmacodynamic characteristics of intravenous and inhaled nicotine. J. Pharmacol. Exp. Ther. 234:1–12.PubMedGoogle Scholar
  143. Herning, R. I., and Pickworth, W. B., 1985, Nicotine gum improves stimulus processing during tobacco withdrawal, Psychophysiology 22:595.Google Scholar
  144. Herning, R. I., Jones, R. T., and Backman, J., 1983, EEG changes during tobacco withdrawal, Psychophysiology 20:507–512.PubMedCrossRefGoogle Scholar
  145. Hickey, N., and Mulcahy, R., 1973, Effect of cessation of smoking on body weight after myocardial infarction, Am. J. Clin. Nutr. 26:385–386.PubMedGoogle Scholar
  146. Higgins, M. W., and Kjelsberg, M., 1967, Characteristics of smokers and nonsmokers in Tecumseh, Michigan, Am. J. Epidemiol. 86:60–77.PubMedGoogle Scholar
  147. Higgins, S. T., Preston, K., Cane, E., Henningfield, J., and Jaffee, J., 1988, Behavioral, physiological and hormonal effects of a naloxone challenge following acute morphine pre-treatment in humans, in: Problems of Drug Dependence, 1987, NIDA Research Monograph 81 (L. S. Harris, ed.), pp. 202–208, U.S. Government Printing Office, Washington, DC.Google Scholar
  148. Hjalmarson, A. I., 1984, Effect of nicotine chewing gum in smoking cessation: A randomized, placebo-controlled, double-blind study, JAMA 252:2835–2838.PubMedCrossRefGoogle Scholar
  149. Hofstetter, A., Schutz, Y., Jequier, E., and Wahren, J., 1986, Increased 24-hour energy expenditure in cigarette smokers, N. Engl. J. Med. 314:79–82.PubMedCrossRefGoogle Scholar
  150. Hughes, J. R., 1984, Identification of the dependent smoker, Validity and clinical utility, Behav. Med. Abstr. 5:202–204.Google Scholar
  151. Hughes, J. R., 1986a, Genetics of smoking: A brief review, Behav. Ther. 17:335–345.CrossRefGoogle Scholar
  152. Hughes, J. R., 1986b, Craving as a psychological construct, Br. J. Addict. 82:38–39.CrossRefGoogle Scholar
  153. Hughes, J. R., 1988, Clonidine, depression and smoking cessation, JAMA 254:2901–2902.CrossRefGoogle Scholar
  154. Hughes, J. R., in press, Similarities and differences in drug withdrawal syndromes in: Addiction Counseling: The Role of the Family Physician, The Medicine Group, Toronto.Google Scholar
  155. Hughes, J. R., and Hatsukami, D. K., 1985, Short-term effects of nicotine gum, in: Pharmacological Adjuncts in Smoking Cessation, NIDA Research Monograph, No. 53 (J. Grabowski and S. M. Hall, eds.), pp. 68–82, U.S. Government Printing Office, Washington, DC.Google Scholar
  156. Hughes, J. R., and Hatsukami, D. K., 1986, Signs and symptoms of tobacco withdrawal, Arch. Gen. Psychiatry 43:289–294.PubMedCrossRefGoogle Scholar
  157. Hughes, J. R., and Hatsukami, D. K., 1987, Criteria of a pharmacologic withdrawal syndrome, Arch. Gen. Psychiatry 44:393–394.Google Scholar
  158. Hughes, J. R., and Krahn, D., 1985, Blindness and the validity of double-blind drug trials, J. Clin. Psychopharmacol. 5:138–142.PubMedCrossRefGoogle Scholar
  159. Hughes, J. R., and Miller, S., 1984, Nicotine gum to help stop smoking, JAMA 252:2855–2858.PubMedCrossRefGoogle Scholar
  160. Hughes, J. R., and Valliere, W., 1988, Are ex-smokers nonsmokers? Unpublished manuscript.Google Scholar
  161. Hughes, J. R., Hatsukami, D., Carroll, K., and Pickens, R. W., August 1982a, Effects of smoking cessation on weight, eating and activity, Presented at Annual Meeting of the American Psychological Association, Washington, DC.Google Scholar
  162. Hughes, J. R., O’Hara, M. W., and Rehm, L. P., 1982b, Measurement of depression in clinical trials: A critical overview, J. Clin. Psychiatry 43:85–88.PubMedGoogle Scholar
  163. Hughes, J. R., Hatsukami, D. K., Pickens, R. W., Krahn, D., Malin, S., and Luknic, A., 1984a, Effect of nicotine on the tobacco withdrawal syndrome, Psychopharmacology 83:82–87.PubMedCrossRefGoogle Scholar
  164. Hughes, J. R., Hatsukami, D. K., and Pickens, R. W., 1984b, The effect of Nicorette on the signs and symptoms of the tobacco withdrawal syndrome, Project Report Y-84–07, Merrell Dow Research Institute, Indianapolis.Google Scholar
  165. Hughes, J. R., Hatsukami, D. K., Pickens, R. W., and Svikis, D. S., 1984c, Consistency of the tobacco withdrawal syndrome, Addict. Behav. 9:409–412.PubMedCrossRefGoogle Scholar
  166. Hughes, J. R., Gust, S. W., Keenan, R. M., Skoog, K. P., Pickens, R. W., Ramlet, D., and Healey, M., August 1986a, Efficacy of nicotine gum in general practice, Presented at the Annual Meeting of the American Psychological Association, Washington, DC.Google Scholar
  167. Hughes, J. R., Hatsukami, D. K., and Skoog, K., 1986b, Physical dependence on nicotine gum: A placebo-substitution trial, JAMA 255:3277–3279.PubMedCrossRefGoogle Scholar
  168. Hughes, J. R., Hatsukami, D. K., Mitchell, J. E., and Dahlgren, B. A., 1986c, Prevalence of smoking in psychiatric outpatients, Am. J. Psychiatry 143:993–997.PubMedGoogle Scholar
  169. Hughes, J. R., Arana, G., Amori, G., and Stewart, F., 1988, Effect of tobacco withdrawal on the dexamethasone suppression test, Biol. Psychiatry 23:96–98.PubMedCrossRefGoogle Scholar
  170. Hughes, J. R., Gulliver, S., Amori, G., and Mireault, G., in press-a, Effects of instructions and nicotine gum on smoking cessation, withdrawal symptoms and self-administration of nicotine gum, Psychopharmacology. Google Scholar
  171. Hughes, J. R., Keenan, R., and Yellin, A., in press-b, Effect of tobacco withdrawal on sustained attention, Addict. Behav. Google Scholar
  172. Hughes, J. R., Strickler, G., King, D., Gulliver, S., Mireault, G., and Fenwick, J. W., Smoking history instructions and the effects of nicotine: Two pilot studies, Pharm. Biochem. Behav. (in press).Google Scholar
  173. Hunt, S. N., Jusko, W. J., and Yurchak, A. M., 1976, Effect of smoking on theophylline distribution, Clin. Pharmacol. Ther. 9:546–551.Google Scholar
  174. Hutchinson, R. R., and Emley, G. S., 1973, Effects of nicotine on avoidance, conditioned suppression and aggression response measures in animals and man, in: Smoking Behavior: Motives and Incentives (W. L. Dunn, ed.), pp. 171–196, Holt, New York.Google Scholar
  175. Hutchinson, R. R., and Emley, G. S., 1981, Nicotine ingestion reduces elevated blood pressures in rats and squirrel monkeys, Life Sci. 28:801–809.PubMedCrossRefGoogle Scholar
  176. Hutchinson, R. R., and Emley, G. S., 1986, Behavioral effects of nicotine, in: Advances in Behavioral Pharmacology, Volume 4, (T. Thompson and J. Barrett, eds.) Academic Press, New York.Google Scholar
  177. Ikard, F. F., Green, D. E., and Horn, D., 1969, A scale to differentiate between types of smoking as related to the management of affect, Int. J. Addict. 4:649–659.Google Scholar
  178. Istvan, J., and Matarazzo, J. D., 1984, Tobacco, alcohol and caffeine use: A review of their interrelationships, Psychol. Bull. 95:301–326.PubMedCrossRefGoogle Scholar
  179. Itel, T. M., Ulett, G. A., Hsu, W., Klingenberg, H., and Ulett, J. A., 1971, The effects of smoking withdrawal on quantitatively analyzed EEG, Clin. EEG 2:44–51.Google Scholar
  180. Jacobs, D. R., and Gottenborg, S., 1981, Smoking and weight: The Minnesota Lipid Research Clinic, Am. J. Public Health 71: 391–396.PubMedCrossRefGoogle Scholar
  181. Jaffe, J. H., 1977, Tobacco use as a mental disorder: The rediscovery of a medical problem, in: Research in Smoking Behavior, NIDA Research Monograph No. 17 (N. Krasnegor, ed.), pp. 202–219, U.S. Government Printing Office, Washington, DC.Google Scholar
  182. Jaffe, J. H., 1980, Drug addiction and drug abuse, in: The Pharmacologic Basis of Therapeutics, 6th ed. (A. G. Gilman, L. S. Goodman, and A. Gilman, eds.), pp. 535–584, Macmillan, New York.Google Scholar
  183. Jamrozik, K., Vessey, M., and Wald, N., 1984, Placebo-controlled trial of nicotine chewing gum in general practice, Br. Med. J. 289:794–797.CrossRefGoogle Scholar
  184. Jarvik, M. E., 1979, Biological influences on cigarette smoking, in: Smoking and Health: A Report of the Surgeon General, Chapter 15, U.S. Government Printing Office, Washington, DC.Google Scholar
  185. Jarvis, M. J., Hajek, P., Russell, M. A. H., and West, R. J., in press, Nasal nicotine solution as an aid to cigarette withdrawal: A pilot clinical trial, Br. J. Addict. Google Scholar
  186. Jasinski, D. R., Johnson, R. E., and Kocher, T. R., 1985, Clonidine in morphine withdrawal: Differential effects in signs and symptoms, Arch. Gen. Psychiatry 42:1063–1066.PubMedCrossRefGoogle Scholar
  187. Jones, R. A., 1986, Individual differences in nicotine sensitivity, Addict. Behav. 11:435–438.PubMedCrossRefGoogle Scholar
  188. Jones, R. T., Farrell, T. R., and Herning, R. I., 1978, Tobacco smoking and nicotine tolerance, in: Self-administration of Abused Substances: Methods for Study, NIDA Research Monograph, No. 20 (N. A. Krasnegor, ed.), pp. 202–208, U.S. Government Printing Office, Washington, DC.Google Scholar
  189. Kahn, A., Ciraulo, D., Nelson, W. H., Becker, J. T., Nies, A., and Jaffe, J., 1984, Dexamethasone suppression test in recently detoxified alcoholics: Clinical implications, J. Clin. Psychopharmacol. 4:94–97.CrossRefGoogle Scholar
  190. Kalant, H., LeBlanc, A. E., and Griffins, R. J., 1971, Tolerance to, and dependence on, some non-opiate psychotropic drugs, Pharmacol. Rev. 23:135–191.PubMedGoogle Scholar
  191. Kales, J., Allen, C., Preston, T., Tan, T., and Kales, A., 1970, Changes in REM sleep and dreaming with cigarette smoking and following withdrawal, Psychophysiology 7:347–348.Google Scholar
  192. Karanci, N. A., 1985, Individual nicotine requirements: The relationship between differences in nicotine intake and physiological response, Biol. Psychol. 21:27–42.PubMedCrossRefGoogle Scholar
  193. Karras, A., Kane, J. M., 1980, Naloxone reduces cigarette smoking, Life Sci. 27:1541–1543.PubMedCrossRefGoogle Scholar
  194. Katz, J. L., and Valentino, R. J., 1986, Pharmacological and behavioral factors in opioid dependence in animals, in: Behavioral Analysis of Drug Dependence (S. R. Goldberg and I. P. Stolerman, eds.), pp. 287–315, Academic Press, New York.Google Scholar
  195. Keenan, A., and Johnson, F. N., 1972, Development of behavioral tolerance to nicotine in the rat, Specialia 5:428–429.Google Scholar
  196. Killen, J. C., Maccoby, N., and Taylor, C. B., 1984, Nicotine gum and self-regulation training in smoking relapse prevention, Behav. Ther. 15:234–248.CrossRefGoogle Scholar
  197. Killen, J., Taylor, C., Maccoby, N., and Young, J., 1987, Investigating predictors of smoking relapse: An analysis of biochemical and self-report measures of tobacco dependence, Unpublished manuscript.Google Scholar
  198. Kleinman, K., Vaughn, R., and Christ, T., 1973, Effects of cigarette smoking and smoking deprivation on paired-associate learning of high and low meaningful nonsense syllables, Psychol. Rep. 32:963–966.PubMedCrossRefGoogle Scholar
  199. Klesges, R. C., and Klesges, L. M., 1987, Cigarette smoking as a dieting strategy in a young adult sample, Unpublished manuscript.Google Scholar
  200. Klesges, R. C., Eck, L. H., Clark, E. M., Meyers, A. W., and Hanson, C. L., 1988a, The effects of smoking cessation and gender on dietary intake, physical activity and weight gain, Unpublished manuscript.Google Scholar
  201. Klesges, R. C., Meyers, A. W., and LaVasque, M. E., 1988b, Smoking, body weight and their effects on smoking behavior: A comprehensive review of the literature, Unpublished manuscript.Google Scholar
  202. Knapp, P. H., Bliss, C. M., and Wells, H., 1963, Addictive aspects in heavy cigarette smoking, Am. J. Psychiatry 119:966–972.PubMedGoogle Scholar
  203. Knott, V. J., and Venables, P. H., 1977, EEG alpha correlates of non-smokers, smokers smoking, and smoking deprivation, Psychophysiology 14:150–156.PubMedCrossRefGoogle Scholar
  204. Knott, V. J., and Venables, P. H., 1978, Stimulus intensity control and the cortical evoked response in smokers and non-smokers, Psychophysiology 15:186–192.PubMedCrossRefGoogle Scholar
  205. Knott, V. J., and Venables, P. H., 1979, EEG alpha correlates of alcohol consumption in smokers and nonsmokers: Effect of smoking and smoking deprivation, J. Stud. Alcohol 40:247–257.PubMedGoogle Scholar
  206. Kozlowski, L. T., and Wilkinson, D. A., 1937, Use and misuse of the concept of “craving” by alcohol, tobacco and drug researchers, Br. J. Addict. 82:31–36.CrossRefGoogle Scholar
  207. Krasnegor, R. A., ed., 1978, Self-Administration of Abused Substances: Methods for Study, NIDA Research Monograph No. 20, U.S. Government Printing Office, Washington, DC.Google Scholar
  208. Ksir, C., Hakan, P., Hall, D. P., Jr., and Kellar, K. J., 1985, Exposure to nicotine enhances the behavioral stimulant effect of nicotine and increases binding of [3H] acetylcholine to nicotinic receptors, Neuropharmacology 24:527–531.PubMedCrossRefGoogle Scholar
  209. Lal, H., Harris, C.M., and Emmett-Oglesby, M. W., May 1985, Nicotine withdrawal symptom is increased by a GABA synthesis inhibitor, Presented at Society for Neuroscience, Minneapolis, MN.Google Scholar
  210. Larson, P. S., and Silvette, H., 1961, Tobacco: Experimental and Clinical Studies, Williams & Wilkins, Baltimore.Google Scholar
  211. Larson, P. S., and Silvette, H., 1968, Tobacco: Experimental and Clinical Studies, Supplement I, Williams & Wilkins, Baltimore.Google Scholar
  212. Larson, P. S., and Silvette, H., 1971, Tobacco: Experimental and Clinical Studies, Supplement II, Williams & Wilkins, Baltimore.Google Scholar
  213. Larson, P. S., and Silvette, H., 1975, Tobacco: Experimental and Clinical Studies, Supplement III, Williams & Wilkins, Baltimore.Google Scholar
  214. Larsson, P. A., Dahlstrom, A., Heiwaii, P-O., and Booj, S., 1980, The effect of chronic nicotine and withdrawal on intra-axonal transport of acetylcholine and related enzymes in sciatic nerve of the rat, J. Neural. Transm. 47:243–251.PubMedCrossRefGoogle Scholar
  215. Lawrence, P. S., Amodei, N., and Murray, A., November 1982, Withdrawal symptoms associated with smoking cessation, Presented at the Annual Convention of the Association for the Advancement of Behavior Therapy.Google Scholar
  216. Lee, B. L., Benowitz, N. L., and Jacob, P., 1987a, Influence of tobacco abstinence on the disposition kinetics and effects of nicotine, Clin. Pharmacol. Ther. 41:474–478.PubMedCrossRefGoogle Scholar
  217. Lee, B. L., Benowitz, N. L., and Jacob, P., 1987b, Cigarette abstinence, nicotine gum and theophylline disposition, Ann. Intern. Med. 106:553–555.PubMedCrossRefGoogle Scholar
  218. Leventhal, H., and Cleary, P. D., 1980, The smoking problem: A review of the research and theory in behavioral risk modification, Psychol. Bull. 88:370–405.PubMedCrossRefGoogle Scholar
  219. Levin, E. D., Morgan, M. M., Galvez, C., and Ellison, G., 1987, Chronic nicotine and withdrawal effects on body weight and food and water consumption in female rats, Physiol. Behav. 39:441–444.PubMedCrossRefGoogle Scholar
  220. Levinson, P. R., Gernstein, D. R., and Maloff, D. R., eds., 1983, Commonalities in Substance Abuse and Habitual Behavior, Lexington Books, Lexington, MA.Google Scholar
  221. Littlewood, J., Glover, V., Sander, M., Peatfield, R., Petty, R., and Rose, F. C., 1984, Low platelet monoamine oxidase activity in headache: No correlation with phenolsulphastransferase, succinate dehydrogenose, platelet preparation method and smoking, J. Neurol. Neurosurg. Psychiatry 47: 338–352.PubMedCrossRefGoogle Scholar
  222. Lund-Larsen, P. G., and Tretle, S., 1982, Changes in smoking habits and body weight after a three-year period—The Cardiovascular Disease Study in Finnmark, J. Chronic Dis. 35:773–780.PubMedCrossRefGoogle Scholar
  223. MacAndrews, C., 1979, On the possibility of the psychometric detection of persons who are prone to the abuse of alcohol and other substances, Addict. Behav. 9:11–20.CrossRefGoogle Scholar
  224. Malcolm, R. E., Sillett, R. W., Turner, J. A. McM., and Ball, K. P., 1980, The use of nicotine chewing gum as an aid to stopping smoking, Psychopharmacology 70:295–296.PubMedCrossRefGoogle Scholar
  225. Mangan, G. L., 1982, The effects of cigarette smoking on vigilance performance, J. Gen. Psychol. 106: 77–83.PubMedCrossRefGoogle Scholar
  226. Mangan, G. L., and Golding, J. F., 1984, The Psychopharmacology of Smoking, Cambridge University Press, Cambridge.Google Scholar
  227. Manley, R., and Boland, F., 1983, Side-effects and weight gain following a smoking cessation program, Addict. Behav. 8:375–380.PubMedCrossRefGoogle Scholar
  228. Marks, M. J., Burch, J. B., and Collins, A. C., 1983, Effects of chronic nicotine infusion on tolerance development and nicotine receptors, J. Pharmacol. Exp. Ther. 226:817–825.PubMedGoogle Scholar
  229. Marks, M. J., Stitzel, J., and Collins, A. C., 1985, Time course study of the effects of chronic nicotine infusion on drug response and brain receptors, J. Pharmacol. Exp. Ther. 235:619–628.PubMedGoogle Scholar
  230. Martin, W., ed., 1977, Drug Addiction I and II: Handbook of Experimental Pharmacology, Volume 45, Springer-Verlag, New York.Google Scholar
  231. Martin, W. R., and Jasinski, D. R., 1969, Physiological parameters of morphine dependence in non-tolerance, early abstinence and protracted abstinence, J. Psychiatr. Res. 7:9–17.PubMedCrossRefGoogle Scholar
  232. Matarazzo, J. D., and Saslow, G., 1960, Psychological and related characteristics of smokers and nonsmokers, Psychol. Bull. 57:493–513.PubMedCrossRefGoogle Scholar
  233. McCarty, M. F., 1982, Nutritional support of central catecholaminergic tone may aid smoking withdrawal, Med. Hypotheses 8:95–102.PubMedCrossRefGoogle Scholar
  234. McNair, E., and Bryson, R., 1983, Effects of nicotine on weight change and food consumption in rats, Pharmacol. Biochem. Behav. 18:341–344.PubMedCrossRefGoogle Scholar
  235. McNeill, A. D., West, R. J., Jarvis, M., Jackson, P., and Bryant, A., 1986, Cigarette withdrawal symptoms in adolescent smokers, Psychopharmacology 90:533–536.PubMedCrossRefGoogle Scholar
  236. Melander, A., Nordenskjold, E., Lundh, B., and Thorell, J., 1981, Influence of smoking on thyroid activity, Acta Med. Scand. 209:41–43.PubMedCrossRefGoogle Scholar
  237. Mello, N. K., and Mendelson, J. H., 1977, Clinical aspects of alcohol dependence, in: Drug Addiction, Handbook of Experimental Pharmacology, Volume 45 (W. Martin, ed.), pp. 613–666, Springer-Verlag, New York.CrossRefGoogle Scholar
  238. Milgrom-Friedman, J., Penman, R., and Meares, R., 1983, A preliminary study on pain perception and tobacco smoking, Clin. Exp. Pharmacol. Physiol. 10:161–169.PubMedCrossRefGoogle Scholar
  239. Morgan, M. M., and Ellison, G., 1987, Different effects of chronic nicotine treatment regimens on body weight and tolerance in the rat, Psychopharmacology 91:236–238.PubMedCrossRefGoogle Scholar
  240. Morrison, C. F., 1974a, Effects of nicotine and its withdrawal on the performance of rats on signaled and unsignaled avoidance schedules, Psychopharmacology 38:25–35.CrossRefGoogle Scholar
  241. Morrison, C. F., 1974b, Effects of nicotine on the observed behavior of rats during signalled and unsignalled avoidance experiments, Psychopharmacology 38:37–46.CrossRefGoogle Scholar
  242. Morrison, C.F., and Stephenson, J. A., 1972, The occurrence of tolerance to a central depressant effect of nicotine, Br. J. Pharmacol. 45:151–156.CrossRefGoogle Scholar
  243. Mule, S. J., 1981, Behavior in Excess: An Examination of the Volitional Disorders, Free Press, London.Google Scholar
  244. Murphee, H. B., 1979, EEG effects in humans of nicotine, tobacco smoking, withdrawal from smoking and possible surrogates, in: Electrophysiological Effects of Nicotine (A. Remond and C. Izard, eds.), pp. 227–243, Elsevier/North Holland Biomedical Press, Amsterdam.Google Scholar
  245. Murphee, H. B., and Schultz, R. E., 1968, Abstinence effects in smokers, Fed. Proc. 27:220.Google Scholar
  246. Murray, A. L., and Lawrence, P. S., 1984, Sequalae to smoking cessation: A review, Clin. Psychol. Rev. 4:143–157.CrossRefGoogle Scholar
  247. Myrsten, A. L., Elgerot, A., and Edgren, B., 1977, Effects of abstinence from tobacco smoking on physiological and psychological arousal levels in habitual smokers, Psychosom. Med. 39: 25–38.PubMedGoogle Scholar
  248. National Institute on Drug Abuse, 1983, Why People Smoke Cigarettes, U.S. Government Printing Office, Washington, DC.Google Scholar
  249. Nelson, J. M., and Goldstein, L.,1972, Improvement of performance on an attention task with chronic nicotine treatment in rats, Psychopharmacology 26:347–360, 1972.CrossRefGoogle Scholar
  250. Nelson, J. M., and Goldstein, L., 1973, Chronic nicotine treatment in rats: 1. Acquisition and performance of an attention task, Res. Commun. Chem. Pathol. Pharmacol. 5:681–693.Google Scholar
  251. Nemeth-Coslett, R., and Griffiths, R. R., 1986, Naloxone does not affect cigarette smoking, Psychopharmacology 89:261–264.PubMedCrossRefGoogle Scholar
  252. Nemeth-Coslett, R., Henningfield, J. E., O’Keefe, M. K., and Griffiths, R. R., 1986a, Effects of mecamylamine on human cigarette smoking and subjective ratings, Psychopharmacology 88:420–425.PubMedCrossRefGoogle Scholar
  253. Nemeth-Coslett, R., Sampson, A., and Henningfield, J. E., August 1986b, Subjective and physiological correlates of cigarette deprivation, Presented at the Annual Meeting of the American Psychological Association, Washington, DC.Google Scholar
  254. Nesbitt, P. D., 1973, Smoking, physiological arousal, and emotional response, J. Person. Soc. Psychol. 25:137–144.CrossRefGoogle Scholar
  255. Niaura, R., Abrams, D., Demuth, B., Monti, P., and Pinto, R., in press, Response to smoking-related stimuli and early relapse, Addict. Behav. Google Scholar
  256. Nil, R., Woodson, P. P., and Battig, K., 1987, Effects of smoking deprivation on smoking behavior and heart rate response in high- and low-CO absorbing smokers, Psychopharm. 92:465–469.CrossRefGoogle Scholar
  257. Norman, T. R., Chamberlain, K. G., and French, M. A., 1987, Platelet monoamine oxidase: Low activity in cigarette smokers, Psychiatry Res. 20:199–205.PubMedCrossRefGoogle Scholar
  258. Olbrisch, M., and Oades-Souther, D., August 1986, Smoking cessation and changes in food, alcohol, and caffeine intake, Presented at the Annual Meeting of the American Psychological Association, Washington, DC.Google Scholar
  259. Ornish, S. A., Zisook, S., and McAdams, L. A., 1988, Effects of transdermal Clonidine treatment on withdrawal symptoms associated with smoking cessation: A randomized, controlled trial, Arch. Intern. Med. 148:2027–2031.PubMedCrossRefGoogle Scholar
  260. Overton, P. A., 1984, State dependent learning and drug discriminations, in: Handbook of Psychopharmacology, Vol. 18 (L. L. Iversen, S. D. Iversen, and S. H. Snyder, eds.), pp. 59–127, Plenum, New York.Google Scholar
  261. Pangborn, R. M., and Trabue, I. M., 1973, Gustatory responses during periods of controlled and ad-lib smoking, Percept. Psychophysics 7:139–144.CrossRefGoogle Scholar
  262. Pangborn, R. M., Trabue, I. M., and Barylko-Pikielna, N., 1967, Taste, odor, and tactile discrimination before and after smoking, Percept. Psychophysics 2:529–532.CrossRefGoogle Scholar
  263. Parsons, L. C., and Hamme, S., 1975, The effects of nicotine withdrawal on the sleep awake cycle, Va. J. Sci. 27:86.Google Scholar
  264. Parsons, L. C., Avery, S., Christman, S., Hopkins, J., and Seal, M., 1975a, The effects of 48 hour nicotine withdrawal on heart rate and respiration through continuous monitoring of all night sleep patterns in adult females, Va. J. Sci. 26:92.Google Scholar
  265. Parsons, L. C., Bell, N., Comer, L., Swartz, A., and Weissenborn, C., 1975b, The effects of short-term nicotine withdrawal on day vigilance as measured electrophysiologically, Va. J. Sci. 27:86.Google Scholar
  266. Parsons, L. C., Luttrell, N., Mabe, J., and Pollock, P., 1975c, The effect of 48 hour nicotine withdrawal on all night sleep patterns in adult females, Va. J. Sci. 26:92.Google Scholar
  267. Perlick, D., 1978, The withdrawal syndrome: Nicotine addiction and the effects of stopping smoking in heavy and light smokers, cited in Schacter, 1978.Google Scholar
  268. Pertschuk, M., Pomerleau, O., Adkins, D., and Hirsch, C., 1979, Smoking cessation: The psychological costs, Addict. Behav. 4:345–348.PubMedCrossRefGoogle Scholar
  269. Pickworth, W. B., Herning, R. I., and Henningfield, J. E., 1988, Mecamylamine reduces some EEG effects of nicotine chewing gum in humans, Pharmacol. Biochem. Behav. 30:149–153.PubMedCrossRefGoogle Scholar
  270. Pohorecky, L. A., Newman, B., Sun, J., and Bailey, W. H., 1978, Acute and chronic ethanol ingestion and serotonin metabolism in rat brain, J. Pharmacol. Ther. 204:424–432.Google Scholar
  271. Pomerleau, O. F., and Pomerleau, C. F., 1984, Neuroregulators and the reinforcement of smoking: Towards a biobehavioral explanation, Neurosci. Biobehav. Rev. 8:503–513.PubMedCrossRefGoogle Scholar
  272. Pomerleau, O. F., Adkins, D., and Pertschuk, M., 1978, Predictors of outcome and recidivism in smoking cessation treatment, Addict. Behav. 3:65–70.PubMedCrossRefGoogle Scholar
  273. Pomerleau, O. F., Fertig, J., and Shanhan, S., 1983a, Nicotine dependence in cigarette smoking: An empirically-based, multivariate model, Pharmacol. Biochem. Behav. 19:291–299.PubMedCrossRefGoogle Scholar
  274. Pomerleau, O. F., Fertig, J. B., Seyler, L. E., and Jaffe, J., 1983b, Neuroendocrine reactivity to nicotine in smokers, Psychopharmacology 83:61–67.CrossRefGoogle Scholar
  275. Powell, D. R., and McCann, B. S., 1981, The effects of a multiple treatment program and maintenance procedures on smoking cessation, Prev. Med. 10:94–104.PubMedCrossRefGoogle Scholar
  276. Puddey, I. B., Vandongen, R., Berlen, L. J., and English, D., 1984, Haemodynmaic and neuroendocrine consequences of stopping smoking: A controlled study, Clin. Exp. Pharmacol. Physiol. 11: 423–426.PubMedCrossRefGoogle Scholar
  277. Puddey, I. B., Vandongen, R., Berlen, L. J., English, D. R., and Ukich, A. W., 1985, The effect of stopping smoking on blood pressure: A controlled trial, J. Chronic Dis. 38:483–493.PubMedCrossRefGoogle Scholar
  278. Puska, P., Bjorkqvist, S., and Koskela, K., 1979, Nicotine-containing chewing gum in smoking cessation: A double-blind trial with half year followup, Addict. Behav. 4:141–146.PubMedCrossRefGoogle Scholar
  279. Rabkin, S., 1984, Relationship between weight change and the reduction or cessation of cigarette smoking, Int. J. Obesity 8:665–673.Google Scholar
  280. Redington, K., 1984, Taste differences between cigarette smokers and nonsmokers, Pharmacol. Biochem. Behav. 21:203–208.PubMedCrossRefGoogle Scholar
  281. Rodin, J., 1987, Weight change following smoking cessation: The role of food intake and exercise, Addict. Behav. 12:303–317.PubMedCrossRefGoogle Scholar
  282. Rose, J. E., Herskovic, J. E., Trelling, Y., and Jarvik, M. E., 1985, Transdermal nicotine reduces cigarette craving and nicotine preference, Clin. Pharmacol. Ther. 38:450–456.PubMedCrossRefGoogle Scholar
  283. Rosecrans, J. A., Hendry, J. S., and Hong, J. S., 1985, Biphasic effects of chronic nicotine treatment on hypothalamic immunoreactive B-endorphin in the mouse, Pharmacol. Biochem. Behav. 23:141–143.PubMedCrossRefGoogle Scholar
  284. Russell, M. A. H., Peto, J., and Patel, V. A., 1974, The classification of smoking by factorial structure of motives, J. Roy. Statist. Soc. A. 137:313–333.CrossRefGoogle Scholar
  285. Russell, P., Epstein, L., Sittenfield, S., and Block, D., 1984, The effects of nicotine chewing gum and cessation on the perception of muscle tension, Psychopharmacology 89:230–233.CrossRefGoogle Scholar
  286. Sachs, D. P. L., and Benowitz, N. L., in press, The nicotine withdrawal syndrome: Nicotine abstinence or caffeine excess? in: Problems of Drug Dependence, 1988, NIDA Research Monograph (L. S. Harris, ed.), U.S. Government Printing Office, Washington, DC.Google Scholar
  287. Sannita, W., Crotti, N., Massa, T., Morasso, G., Rosadini, G., Timitilli, C., and Valerio, F., 1984, Electrophysiological concomitants of the long-term withdrawal from cigarette smoking: A pilot study, Res. Commun. Psychol. Psychiatry Behav. 9:273–281.Google Scholar
  288. Schachter, S., 1978, Pharmacological and psychological determinants of smoking, Ann. Intern. Med. 88:104–114.PubMedCrossRefGoogle Scholar
  289. Schecter, M. S., and Cook, P. G., 1976, Nicotine-induced weight loss without an effect on appetite, Eur. J. Pharmacol. 38:63–69.CrossRefGoogle Scholar
  290. Schecter, M., and Rand, M., 1974, Effect of acute deprivation of smoking on aggression and hostility, Psychopharmacology 35:19–28.CrossRefGoogle Scholar
  291. Schneider, N. G., and Jarvik, M. E., 1984, Time course of smoking withdrawal symptoms as a function of nicotine replacement, Psychopharmacology 82:143–144.PubMedCrossRefGoogle Scholar
  292. Schneider, N. G., and Jarvik, M. E., 1985, Nicotine gum vs. placebo gum: Comparisons of withdrawal symptoms and success rates, in: Pharmacological Adjuncts in Smoking Cessation, NIDA Research Monograph 53 (J. Grabowski and S. M. Hall, eds.), pp. 83–101, U.S. Government Printing Office, Washington, DC.Google Scholar
  293. Schneider, N. G., Jarvik, M. E., and Forsythe, A. B., 1984, Nicotine vs placebo gum in the allievation of withdrawal during smoking cessation, Addict. Behav. 9:149–156.PubMedCrossRefGoogle Scholar
  294. Schoenenberger, J. C., 1982, Smoking change in relation to changes in blood pressure, weight, and cholesterol, Prev. Med. 11:441–453.PubMedCrossRefGoogle Scholar
  295. Schwartz, R. D., and Kellar, K. J., 1983, Nicotinic cholinergic receptor binding sites in brain: Regulation in vivo, Science 202:214–216.CrossRefGoogle Scholar
  296. Schwartz, R. D., and Kellar, K. J., 1985, In vivo regulation of [3H] acetylcholine recognition sites in brain by nicotinic cholinergic drugs, J. Neurochem 45:427–433.PubMedCrossRefGoogle Scholar
  297. Schwartz, R. D., McGee, R., and Kellar, K. J., 1982, Nicotine cholinergic receptors labeled by [3H] acetycholine in rat brain, Mol. Pharmacol. 22:56–62.PubMedGoogle Scholar
  298. Seltzer, C. C., and Oechsli, F. W., 1985, Psychosocial characteristics of adolescent smokers before they start smoking: Evidence of self-selection, J. Chronic Dis. 38:17–26.PubMedCrossRefGoogle Scholar
  299. Seyler, L. E., Pomerleau, O. F., Fertig, J. B., Hunt, D., and Parker, K., 1986, Pituitary hormone response to cigarette smoking, Pharmacol. Biochem. Behav. 24:159–162.PubMedCrossRefGoogle Scholar
  300. Shiffman, S. M., 1979, The tobacco withdrawal syndrome, in: Cigarette Smoking as a Dependence Process, NID A Research Monograph No. 23 (N. A. Krasnegor, ed.), pp. 158–185, U.S. Government Printing Office, Washington, DC.Google Scholar
  301. Shiffman, S. M., 1982, Relapse following smoking cessation: A situational analysis, J. Consult. Clin. Psychol. 50:71–86.PubMedCrossRefGoogle Scholar
  302. Shiffman, S. M., August 1986, Tobacco “chippers”: A study of non-dependent cigarette smokers, Presented at the Annual Meeting of the American Psychological Association, Washington, DC.Google Scholar
  303. Shiffman, S. M., and Jarvik, M. E., 1976, Smoking withdrawal symptoms in two weeks of abstinence, Psychopharmacology 50:35–39.PubMedCrossRefGoogle Scholar
  304. Shiffman, S. M., and Jarvik, M. E., 1984, Cigarette smoking, physiological arousal, and emotional response: Nesbitt’s paradox re-examined, Addict. Behav. 9:95–98.PubMedCrossRefGoogle Scholar
  305. Shiffman, S. M., Gritz, E. R., Mallese, J., Lee, M. A., Schneider, N. G., and Jarvik, M. E., 1983, Effects of cigarette smoking and oral nicotine on hand tremor, Clin. Pharmacol. Ther. 33:800–805.PubMedCrossRefGoogle Scholar
  306. Sideroff, S. I., Jarvik, M. E., and Mintz, J., 1987, Responses to stimuli associated with smoking: Comparison between ex-smokers and heavy smokers abstaining for 12 hours, Unpublished manuscript.Google Scholar
  307. Siegel, S., 1983, Classical Conditioning, drug tolerance, and drug dependence, in: Research Advances in Alcohol and Drug Problems, Volume 7 (Y. Israel, F. B. Glaser, H. Kalant, R. E. Popham, W. Schmidt, and R. G. Smart, eds.), pp. 207–246, Plenum Press, New York.CrossRefGoogle Scholar
  308. Silverstein, B., 1982, Cigarette smoking, nicotine addiction, and relaxation, J. Person. Soc. Psychol. 42:946–950.CrossRefGoogle Scholar
  309. Smith, P., and Lombardo, T., November 1986, Effect of abstinence from smoking on motor activity, Presented at the Annual Meeting for the Association for the Advancement of Behavior Therapy, Chicago.Google Scholar
  310. Snyder, F., and Henningfield, J., in press, Effects of acute nicotine deprivation and administration: Assessment on computerized performance tasks, Psychopharmacology. Google Scholar
  311. Snyder, F., Davis, F., and Henningfield, J., August 1986, Chronic tobacco abstinence reduces information processing capabilities in heavy smokers, Presented at the Annual Meeting of the American Psychological Association, Washington, DC.Google Scholar
  312. Snyder, F. R., Davis, F. C., and Henningfield, J. E., 1988, Replacement of cigarette smoking with nicotine gum: Effects on information processing, in: Problems of Drug Dependence, 1987, NIDA Research Monograph No. 81 (L. S. Harris, ed.), pp. 327–328, U.S. Government Printing Office, Washington, DC.Google Scholar
  313. Soldatos, C., Kales, J., Scharf, M., Bixler, E., and Kales, A., 1980, Cigarette smoking associated with sleep difficulty, Science 207:551–553.PubMedCrossRefGoogle Scholar
  314. Solomon, R. L., and Corbit, J. D., 1973, An opponent-process theory of motivation: Cigarette addiction, J. Abnorm. Psychol. 81:158–171.PubMedCrossRefGoogle Scholar
  315. Stamford, B. A., Matter, S., Fell, R. D., and Papnek, P., 1986, Effects of smoking cessation on weight gain, metabolic rate, caloric consumption, and blood lipids, Am. J. Clin. Nutr. 43:486–494.PubMedGoogle Scholar
  316. Stewart, J., de Wit, H., and Eikelbom, R., 1984, The role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants, Psychol. Rev. 91:251–268.PubMedCrossRefGoogle Scholar
  317. Stitzer, M. L., and Gross, J., 1988, Nicotine replacement: Effect on post-cessation withdrawal symptoms and weight gain, in: Problems of Drug Dependence, NID A Research Monograph No. 81 (L. Harris, ed.), pp. 53–58, U.S. Government Printing Office, Washington, DC.Google Scholar
  318. Stolerman, I. P., 1986a, Could nicotine antagonists be used in smoking cessation? Br. J. Addict. 81:47–53.PubMedCrossRefGoogle Scholar
  319. Stolerman, I. P., 1986b, Psychopharmacology of nicotine: Stimulus effects and receptor mechanisms, in: Handbook of Psychopharmacology, Volume 19 (L. L. Iverson, S. D. Iverson, and S. H. Snyder, eds.), Plenum Press, New York.Google Scholar
  320. Stolerman, I. P., Goldfarb, T., Fink, R., and Jarvik, M. E., 1973, Influencing cigarette smoking with nicotine antagonists, Psychopharmacology 28:247–259.CrossRefGoogle Scholar
  321. Stumpfe, K. D., 1984, Tobacco withdrawal symptoms, Munchen. Med. Wochenschr. 126:731–735.Google Scholar
  322. Svikis, D. S., Hatsukami, D. K., Hughes, J. R., Carroll, K. M., and Pickens, R. W., 1986, Sex differences in the tobacco withdrawal syndrome, Addict. Behav. 11:459–462.PubMedCrossRefGoogle Scholar
  323. Swan, G., Denk, C., Parker, S., Carmelli, D., Furze, C., and Rosenman, R., in press, Risk factors for late relapse in male and female ex-smokers, Addict. Behav. Google Scholar
  324. Szalai, L, Allon, R., Doyle, J., and Zamel, N., 1986, EEG alpha-reactivity and self-regulation correlates of smoking and smoking deprivation, Psychosom. Med. 48:67–72.PubMedGoogle Scholar
  325. Tarriere, H. C., and Hartmann, F., 1964, Investigation into the effects of tobacco smoke on a visual vigilance task, in: Proceedings of the Second International Congress of Ergonomics, pp. 525–530, cited in Wesnes and Warburton, 1983.Google Scholar
  326. Tennant, F. S., Tarver, A. L., and Rawson, R. A., 1984, Clinical evaluation of mecamylamine for withdrawal from nicotine dependence, in: Problems of Drug Dependence, 1983, NIDA Research Monograph No. 49 (L. S. Harris, ed.), pp. 239–246, U.S. Government Printing Office, Washington, DC.Google Scholar
  327. Temes, J. W., 1973, An opponent process theory of habitual behavior with special reference to smoking, in: Research on Smoking Behavior, NIDA Research Monograph No. 17 (M. E. Jarvik, J. W. Cullen, E. R. Gritz, T. M. Vogt, and L. J. West, eds.), U.S. Government Printing Office, Washington, DC.Google Scholar
  328. Tonnesen, P., Fryd, V., Hansen, M., Helsted, J., Gunnersen, A., Forchammer, H., and Stockner, M., 1988, Effect of nicotine chewing gum in combination with group counseling on the cessation of smoking, N. Engl. J. Med. 318:15–27.PubMedCrossRefGoogle Scholar
  329. Trends in US cigarette use, 1965 to 1980, 1985, in: The Health Consequences of Smoking: Cardiovascular Disease, Appendix B, U.S. Government Printing Office, Washington, DC.Google Scholar
  330. Tuomilehto, J., Nissinen, A., Puska, P., Salonen, J. T., and Jalkanen, L., 1986, Long-term effects of cessation of smoking on body weight, blood pressure and serum cholesterol in the middle-aged population with high blood pressure, Addict. Behav. 11:1–9.PubMedCrossRefGoogle Scholar
  331. Turnbull, M. J., and Kelvin, A. S., 1971, Cigarette dependence, Br. Med. J. 10:115.CrossRefGoogle Scholar
  332. Ulett, J. A., and Itd, T. M., 1969, Quantitative electroencephalogram in smoking and smoking deprivation, Science 164:969–70.PubMedCrossRefGoogle Scholar
  333. Vale, A. L., and Balfour, D. J. K., 1987, The role of hippocampal 5-HT in the effects of nicotine on habituation to an X-maze, Eur. J. Pharmacol. 141:313–317.PubMedCrossRefGoogle Scholar
  334. Wack, J. T., and Rodin, J., 1982, Smoking and its effects on body weight and the systems of caloric regulation, Am. J. Clin. Nutr. 35:366–380.PubMedGoogle Scholar
  335. Wenzel, D. G., and Azmeh, N., 1970, Chronically administered nicotine and the blood pressure of normotensive and renal hypertensive rats, Arch. Int. Pharmacodyn. 187:367–376.PubMedGoogle Scholar
  336. Wesnes, K., and Warburton, D. M., 1983, Smoking, nicotine and human performance, Pharmacol. Ther. 21:189–208.PubMedCrossRefGoogle Scholar
  337. West, R. J., 1984, Psychology and pharmacology in cigarette withdrawal, J. Psychosom. Res. 28:379–386.PubMedCrossRefGoogle Scholar
  338. West, R. J., 1985, Corticotrophin injections to treat cigarette withdrawal symptoms, J. Roy. Soc. Med. 78:1065–1066.PubMedGoogle Scholar
  339. West, R. J., 1986, Use and misuse of craving, Br. J. Addict. 82:39–40.CrossRefGoogle Scholar
  340. West, R. J., and Russell, M. A. H., 1985a, Effects of withdrawal from long-term nicotine gum use, Psychol. Med. 15:891–893.PubMedCrossRefGoogle Scholar
  341. West, R. J., and Russell, M. A. H., 1985b, Pre-abstinence smoke intake and smoking motivation as predictors of severity of cigarette withdrawal symptoms, Psychopharmacology 87:334–336.PubMedCrossRefGoogle Scholar
  342. West, R. J., and Russell, M. A. H., 1987, Cardiovascular and subjective effects of smoking before and after 24 hr of abstinence from cigarettes, Psychopharmacology 92:118–121.PubMedCrossRefGoogle Scholar
  343. West, R. J., and Schneider, N., 1987, Craving for cigarettes, Br. J. Addict. 82:407–415.PubMedCrossRefGoogle Scholar
  344. West, R. J., Jarvis, M. J., Russell, M. A. H., Carruthers, M. E., and Feyerabend, C., 1984a, Effect of nicotine replacement on the cigarette withdrawal syndrome, Br. J. Addict. 79:215–219.PubMedGoogle Scholar
  345. West, R. J., Russell, M. A. H., Jarvis, M. J., and Feyerabend, C., 1984b, Does switching to an ultra-low nicotine cigarette induce nicotine withdrawal effects? Psychopharmacology 84:120–123.PubMedCrossRefGoogle Scholar
  346. West, R. J., Russell, M. A., Jarvis, M. J., Pizzey, T., and Kadam, B., 1984c, Urinary adrenaline concentrations during 10 days of smoking abstinence, Psychopharmacology 84:141–142.PubMedCrossRefGoogle Scholar
  347. West, R. J., Hajek, P., and Belcher, M., 1987, Time course of cigarette withdrawal symptoms during four weeks of treatment with nicotine chewing gum, Addict. Behav. 12:1–5.CrossRefGoogle Scholar
  348. Westling, H., 1976, Experience with nicotine-containing chewing gum in smoking cessation, Lakartid-ningen 73:2549–2552.Google Scholar
  349. Weybrew, B. B., and Stark, J. E., 1967, Psychological and Physiological Changes Associated with Deprivation from Smoking, U.S. Naval Submarine Medical Center Report No. 490, U.S. Navy, Washington, DC.Google Scholar
  350. Wikler, A., 1953, Neurophysiological aspects of the opiate and barbiturate abstinence syndromes, in: Metabolic and Toxic Diseases of the Nervous System, Volume 32, Proceedings of the Association for Research in Nervous and Mental Disease, Williams & Wilkins, Baltimore.Google Scholar
  351. Wikler, A., 1980, Opioid Dependence: Mechanisms and Treatment, Plenum Press, New York.CrossRefGoogle Scholar
  352. Williams, D., 1979, Different cigarette-smoker classification factors and subjective state in acute abstinence, Psychopharmacology 64:231–235.PubMedCrossRefGoogle Scholar
  353. Williamson, D. F., Forman, M. R., Binken, N. J., Gentry, E. M., Remington, P. L., and Trowbridge, F. L., 1987, Alcohol and body weight in United States adults, Am. J. Public Health 77:1324–1330.PubMedCrossRefGoogle Scholar
  354. Winders, S. E., and Grunberg, N. E., August 1987, Nicotine, body weight, food consumption and body composition in rats, Presented at the Annual Meeting of the American Psychological Association, New York.Google Scholar
  355. Wise, R. A., 1983, Brain neuronal systems mediating reward processes, in: Neurobiology of Opiate Reward Mechanisms (J. E. Smith, and J. D. Lane, eds.), pp. 405–438, Elsevier Biomedical Press, New York.Google Scholar
  356. Woods, J. H., Katz, J. L., and Winger, G., 1987, Abuse liability of benzodiazepines, Pharmacol. Rev. 39:251–414.PubMedGoogle Scholar
  357. World Health Organization, 1981, Nomenclature and classification of drug and alcohol-related problems: A WHO memorandum, Bull. WHO 59:225–242.Google Scholar
  358. Zeidenberg, P., Jaffee, J. H., Kazler, M., Levitt, M. D., Langone, J. J., and Van Vunakis, H., 1977, Nicotine: cotinine levels in blood during cessation of smoking, Comp. Psychiatry 18:93–101.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • John R. Hughes
    • 1
  • Stephen T. Higgins
    • 1
  • Dorothy Hatsukami
    • 2
  1. 1.Departments of Psychiatry, Psychology, and Family PracticeUniversity of VermontBurlingtonUSA
  2. 2.Departments of Psychiatry and PsychologyUniversity of MinnesotaMinneapolisUSA

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