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Recent Developments in Alcoholism pp 57–71Cite as

Hypothalamic-Pituitary Function during Alcohol Exposure and Withdrawal and Cocaine Exposure

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Part of the book series: Recent Developments in Alcoholism ((RDIA,volume 10))

Abstract

This chapter examines the neuroendocrine effects of acute exposure to and withdrawal from alcohol and cocaine, with special emphasis on the hypothalamic-pituitary-adrenal (HPA) axis. We present the results from two preliminary controlled inpatient studies that document HPA dysfunction during acute exposure to alcohol and cocaine and during withdrawal from alcohol. We discuss the methodological approach of these studies in comparison to related attempts in the literature to use measures of thyroid and prolactin regulation to predict risk of relapse to alcohol and cocaine use, respectively. Our data and the results of related studies are presented in the context of a proposed index of HPA axis dysfunction that may provide a useful clinical measure of susceptibility to relapse during protracted abstinence from alcohol or cocaine.

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Author information

Authors and Affiliations

  1. West Los Angeles Veterans Administration Medical Center, Brentwood Division, Substance Abuse Service, Los Angeles, California, 90073, USA

    Jeffery N. Wilkins

  2. Treatment and Early Intervention Branch, Addiction Research Center, National Institute on Drug Abuse, and Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, 21224, USA

    David A. Gorelick

  3. Department of Cardiology, Denver General Hospital, Denver, Colorado, 80204, USA

    Koonlawee Nademanee

  4. Department of Anatomy and Cell Biology, UCLA School of Medicine, Los Angeles, California, 90024, USA

    Anna Taylor

  5. West Los Angeles Veterans Administration Medical Center, Brentwood Division, Research Service, Los Angeles, California, 90073, USA

    David S. Herzberg

Authors
  1. Jeffery N. Wilkins
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  2. David A. Gorelick
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  3. Koonlawee Nademanee
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  4. Anna Taylor
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  5. David S. Herzberg
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Editor information

Editors and Affiliations

  1. New York University School of Medicine, New York, New York, USA

    Marc Galanter

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© 1992 Springer Science+Business Media New York

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Wilkins, J.N., Gorelick, D.A., Nademanee, K., Taylor, A., Herzberg, D.S. (1992). Hypothalamic-Pituitary Function during Alcohol Exposure and Withdrawal and Cocaine Exposure. In: Galanter, M. (eds) Recent Developments in Alcoholism. Recent Developments in Alcoholism, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1648-8_3

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  • DOI: https://doi.org/10.1007/978-1-4899-1648-8_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1650-1

  • Online ISBN: 978-1-4899-1648-8

  • eBook Packages: Springer Book Archive

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