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Intracellular Fatty-Acid-Binding Proteins Characteristics and Function

  • Chapter
Subcellular Biochemistry

Part of the book series: Subcellular Biochemistry ((SCBI,volume 16))

Abstract

Fatty acids are distributed by the bloodstream to peripheral tissues that utilize these molecules for energy production, for storage, or in biosynthetic pathways. Fatty acids are transported in plasma in the form of triacylglycerols in chylomicrons and very-low-density lipoproteins, or noncovalently bound to serum albumin. Lipoprotein lipase liberates the ester-bound fatty acids. On their way from the capillary to the intracellular organelles, fatty acids have to pass a series of aqueous spaces and membrane barriers (Figure 1). Fatty acids may be taken up from blood and transferred to the interstitial space by the endothelial cells of the capillary wall. Albumin-fatty acid complexes may also pass the endothelium through clefts or by way of plasmalemmal vesicles that pass through the capillary endothelial cell (Milici et al., 1987).

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Abbreviations

PMFABP:

plasma membrane fatty-acid-binding protein

FABP:

fatty-acid-binding protein

MDGI:

mammary gland-derived growth inhibitor

CRBP:

cellular retinolbinding protein

ELISA:

enzyme-linked immunosorbent assay

K d :

dissociation constant

NMR:

nuclear magnetic resonance

ANS:

1-anilino-8-naphthalene sulfonate

DOCA:

deoxycorticosterone acetate

CoA:

coenzyme A.

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  1. Department of Biochemistry, University of Nijmegen, 6500 HB, Nijmegen, The Netherlands

    René J. A. Paulussen & Jacques H. Veerkamp

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  1. René J. A. Paulussen
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  1. RUCA-Laboratory for Human Biochemistry, University of Antwerp, B2020, Antwerp, Belgium

    H. J. Hilderson

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Paulussen, R.J.A., Veerkamp, J.H. (1990). Intracellular Fatty-Acid-Binding Proteins Characteristics and Function. In: Hilderson, H.J. (eds) Subcellular Biochemistry. Subcellular Biochemistry, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1621-1_7

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