Abstract
Phospholipids are the major lipid component of eukaryotic cell membranes. A diversity of phospholipid structures is reflected in distributions that are unique to specific intracellular membranes, as well as the cytoplasmic and extracytoplasmic surfaces of the membrane bilayer. Matched to the spectrum of phospholipids within the cell are cytosolic phospholipid transfer proteins. As a general class of catalyst, these proteins facilitate the transport of monomeric phospholipid molecules between membrane domains (Kader et al., 1982; Wirtz, 1982; Helmkamp, 1986). Although a number of interesting and often highly suggestive catalytic activities have been demonstrated in vitro for phospholipid transfer proteins, it has proved frustratingly difficult to define any in vivo function.
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Abbreviations
- CerPCho:
-
sphingomyelin
- LacCer:
-
lactosylceramide
- PC:
-
phosphatidylcholine
- PE:
-
phosphatidylethanolamine
- PG:
-
phosphatidylglycerol
- PGP:
-
phosphatidylglycerol phosphate
- PI:
-
phosphatidylinositol
- PI4P:
-
phosphatidylinositol 4-phosphate
- PI(4,5)P2 :
-
phosphatidylinositol 4,5-bisphosphate
- PA:
-
phosphatidate
- PS:
-
phosphatidylserine
- CoA:
-
coenzyme A.
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Helmkamp, G.M. (1990). Transport and Metabolism of Phosphatidylinositol in Eukaryotic Cells. In: Hilderson, H.J. (eds) Subcellular Biochemistry. Subcellular Biochemistry, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1621-1_6
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