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Molecular Aspects of Bladder Outlet Obstruction

  • Chapter
Muscle, Matrix, and Bladder Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 385))

Abstract

Lower urinary tract obstruction is a complex disease process wherein interactions between the partially obstructed urethra, detrusor, and central nervous system leads to a constellation of bladder function abnormalities that may not be totally reversible after relief of the obstruction. Although the precise molecular pathophysiology of obstruction-induced bladder dysfunction is still somewhat uncertain, obstruction of the urethra induces gross anatomical, histological, cellular, and molecular alterations in the bladder wall which impairs both bladder storage and emptying.73,38,9,19,42

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Authors and Affiliations

  1. Division of Urology, The University of Texas Southwestern Medical Center, Dallas, Texas, 7235-9110, USA

    Victor K. Lin Ph.D. & John D. McConnell M.D.

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  1. Victor K. Lin Ph.D.
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  2. John D. McConnell M.D.
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Editors and Affiliations

  1. School of Medicine, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Stephen A. Zderic

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Lin, V.K., McConnell, J.D. (1995). Molecular Aspects of Bladder Outlet Obstruction. In: Zderic, S.A. (eds) Muscle, Matrix, and Bladder Function. Advances in Experimental Medicine and Biology, vol 385. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1585-6_8

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  • DOI: https://doi.org/10.1007/978-1-4899-1585-6_8

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