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Elastic Fibers and Their Role in Bladder Extracellular Matrix

  • Chapter
Muscle, Matrix, and Bladder Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 385))

Abstract

The elastic properties of many tissues of the vertebrate body are due in large part to elastic fibers in the extracellular matrix. In some tissues, such as the skin, they form a relatively small but important fraction of the dry weight (2–4%), while in other tissues, such as large arteries and certain specialized ligaments, they may comprise greater than 50%. In the electron microscope, elastic fibers are seen to be composed of two components.1–3 An amorphous fraction lacking any apparent regular or repeating structure composes upwards of 90% of the mature fiber. The microfibrillar component consists of 10–12 nm fibrils located primarily around the periphery of the amorphous component, but also to some extent interspersed within it (Fig. 1). In addition to being distinguishable morphologically, the two components are chemically distinct. The amorphous portion of the elastic fiber is composed of a single protein, elastin, which is primarily responsible for the elastic properties. Although the exact composition of the microfibrils remains to be defined, it is likely that they are composed of several glycoproteins.4

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Authors and Affiliations

  1. Department of Anatomy & Histology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Joel Rosenbloom, Harry Koo, Pamela S. Howard & Edward J. Macarak

  2. Department of Cell Biology & Physiology, School of Medicine, Washington University, St. Louis, MO, 63110, USA

    Robert Mecham

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  1. Joel Rosenbloom
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  2. Harry Koo
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  4. Robert Mecham
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Editors and Affiliations

  1. School of Medicine, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Stephen A. Zderic

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Rosenbloom, J., Koo, H., Howard, P.S., Mecham, R., Macarak, E.J. (1995). Elastic Fibers and Their Role in Bladder Extracellular Matrix. In: Zderic, S.A. (eds) Muscle, Matrix, and Bladder Function. Advances in Experimental Medicine and Biology, vol 385. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1585-6_19

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  • DOI: https://doi.org/10.1007/978-1-4899-1585-6_19

  • Publisher Name: Springer, Boston, MA

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