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Age Influences the Synergy between Butyrylcholinesterase K Variant and Apolipoprotein E ε4 in Late-Onset Alzheimer’s Disease

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Book cover Structure and Function of Cholinesterases and Related Proteins

Abstract

The presence of the K allele of butyrylcholinesterase (BCHE-K) gave an odds ratio of confirmed late-onset (>65y) Alzheimer’s disease of 2.15 (95% CI: 1.1–4.25) (74 cases, 104 controls). The association was confined to carriers of apolipoprotein E ε4 (APOEε4), in whom the BCHE-K allelic odds ratio of confirmed late-onset AD was 6.9 (1.65–29). When the cohort was stratified by age, significant results were only found in the >75y group, in whom the synergy factor of AD (see box) between BCHE-K and APOEε4 was 26.8 (p=0.02). The BCHE-K allele frequency in APOEε4-positive AD cases increased from 0.07 in those <65y to 0.13 in the 65–75y group and 0.24 in those >75y (p=0.01). These findings suggest strong synergy between BCHE-K and APOEε4 in the risk of AD in subjects >75y.

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Author information

Authors and Affiliations

  1. University Department of Pharmacology, Oxford Project to Investigate Memory and Ageing (OPTIMA), Mansfield Rd, Oxford, OX1 3QT, UK

    D. J. Lehmann, C. Johnston & A. D. Smith

  2. Radcliffe Infirmary, Woodstock Rd, Oxford, OX2 6HE, UK

    D. J. Lehmann, C. Johnston & A. D. Smith

  3. University Department of Statistics, 1 South Parks Road, Oxford, OXI 3TG, UK

    M. Cortina Borja

Authors
  1. D. J. Lehmann
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  2. C. Johnston
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  3. M. Cortina Borja
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  4. A. D. Smith
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Editor information

Editors and Affiliations

  1. Walter Reed Army Institute of Research, Washington, D.C., USA

    Bhupendra P. Doctor  & Mary K. Gentry  & 

  2. University of California, San Diego La Jolla, California, USA

    Palmer Taylor

  3. University of Iowa, Iowa City, Iowa, USA

    Daniel M. Quinn

  4. University of Miami School of Medicine, Miami, Florida, USA

    Richard L. Rotundo

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© 1998 Springer Science+Business Media New York

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Lehmann, D.J., Johnston, C., Borja, M.C., Smith, A.D. (1998). Age Influences the Synergy between Butyrylcholinesterase K Variant and Apolipoprotein E ε4 in Late-Onset Alzheimer’s Disease. In: Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. (eds) Structure and Function of Cholinesterases and Related Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1540-5_44

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  • DOI: https://doi.org/10.1007/978-1-4899-1540-5_44

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1542-9

  • Online ISBN: 978-1-4899-1540-5

  • eBook Packages: Springer Book Archive

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