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Genetic Polymorphisms and Arterial Thrombosis

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Recent Advances in Geriatrics

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Abstract

In Western countries, acute myocardial infarction and stroke, are major causes of morbidity and mortality (1). An occlusive coronary thrombus on an ulcerated atherosclerotic plaque in the coronary arteries is the central event in more than 90% of patients with Q-wave myocardial infarction (2). The underlying abnormality in non-Q-wave infarctions is a ruptured atherosclerotic plaque, which acts as a nidus for the deposition and activation of platelets. Atherosclerotic changes in the carotid and vertebrobasilar arteries resemble those of coronary arteries (3). These lesions may progress to local occlusions, but most often do not become symptomatic until embolization to more distal arteries takes place (ischemic stroke). In the cerebral arteries, vessel wall and lumen may be normal until the artery is occluded by an embolus from a more proximal arterial lesion or from the heart (4). Rather than to emboli, occlusion of the small penetrating arteries is often due to degenerative changes of the vessels or to extracranial large-artery disease (5).

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Authors and Affiliations

  1. Unità di Trombosi e Aterosclerosi, IRCCS “Casa Sollievo della Sofferenza” S. Giovanni Rotondo, Istituto di Biochimica e Biotecnologie, Università degli Studi di Napoli, “Federico II”, Italy

    Maurizio Margaglione, Elvira Grandone, Francesco P. Mancini & Giovanni Di Minno

  2. Cattedra di Gerontologia e Geriatria, Università degli Studi di Palermo, Italy

    Maurizio Margaglione, Elvira Grandone, Francesco P. Mancini & Giovanni Di Minno

Authors
  1. Maurizio Margaglione
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  2. Elvira Grandone
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  3. Francesco P. Mancini
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  4. Giovanni Di Minno
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Editor information

Editors and Affiliations

  1. University of Palermo, Palermo, Italy

    Mario Barbagallo  & Giuseppe Licata  & 

  2. School of Medicine, Wayne State University, Detroit, Michigan, USA

    James R. Sowers

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© 1998 Springer Science+Business Media New York

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Margaglione, M., Grandone, E., Mancini, F.P., Di Minno, G. (1998). Genetic Polymorphisms and Arterial Thrombosis. In: Barbagallo, M., Licata, G., Sowers, J.R. (eds) Recent Advances in Geriatrics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1483-5_22

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  • DOI: https://doi.org/10.1007/978-1-4899-1483-5_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1485-9

  • Online ISBN: 978-1-4899-1483-5

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