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Breast Milk Taurine and its Possible Influence on the Development of Breast Milk Induced Jaundice of the Neonate — A Hypothesis

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 359))

Abstract

Breast milk-induced jaundice is a well-known entity in otherwise healthy breast-fed newborns (5). Unconjugated bilirubin characteristically increases after the fourth day of life and peaks around the second week. The pathogenesis of breast milk-induced jaundice is largely unknown although some hypotheses have become quite popular such as a cholestatic effect of breast milk pregnane-3,20- diol (2), or the glucuronyltransferase blocking effect of large amounts of long chain fatty acids in breast milk with high lipase activity (15).

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References

  1. Adams, J.A., Hey, D.J., and Hall, R.T. 1985, Incidence of hyperbilirubinemia in breast vs. formula-fed infants, Clin.Pediair., 24:69–71.

    Article  CAS  Google Scholar 

  2. Arias, I.M., Gartner, L.M., Seifert, B., and Furman, M. 1964, Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steroid, pregnane-3,20 β-diol in maternal milk that inhibits glucuronide formation in vitro, J.Clin.Invest., 43:2037–2046.

    Article  CAS  Google Scholar 

  3. Bock, H.E., Kaufmann, W., and Löhr, G.W. 1981, “Pathophysiologie”, Georg Thieme Verlag, Stuttgart.

    Google Scholar 

  4. Dahms, B.B., Krauss, A.N., Gartner, L.M., Klain, D., Soodalter, J., and Aulk, P.A.M. 1973, Breastfeeding and serum bilirubin values during the first 4 days of life, J.Pediatr., 83:1049–1054.

    Article  CAS  Google Scholar 

  5. Gartner, L.M. and Arias, I.M. 1966, Studies of prolonged neonatal jaundice in the breast fed infant, J.Pediatr., 68:54–55.

    Article  CAS  Google Scholar 

  6. Gartner, L.M. and Lee, K.S. 1993, Jaundice in the breast-fed infant: new concepts of pathogenesis, in: “Human milk: Its Biological and Social Values”, Freier, S. and Eidelman, A.I., eds., Excerpta Medica, Amsterdam, pp. 153.

    Google Scholar 

  7. Grundy, S.M., Ahrens, E.H., and Miettinen, T.A. 1965, Quantitative isolation and gas-liquid Chromatographic analysis of total fecal bile acids, J.Lipid Res., 6:397–409.

    CAS  Google Scholar 

  8. Hammons, J.L., Jordan, W.E., Stewart, R.L., Taulbee, J.D., and Berg, R.W. 1988, Age and effects on fecal bile acids in infants, J.Pediatr.Gastroenterol.Nutr., 7:30–38.

    Article  CAS  Google Scholar 

  9. Järvenpää, A.-L., Rassin, D.K., Kuitunen, P., Gaull, G.E., and Räihä, N.C.R. 1983, Feeding the low birth-weight infant. III. Diet influences bile acid metabolism, Pediatrics, 72:677–683681.

    Google Scholar 

  10. Kuhr, M. and Paneth, N. 1982, Feeding practices and early neonatal jaundice, J.Pediatr.Gastroenterol.Nutr., 7:30–38.

    Google Scholar 

  11. Lascari, A.D. 1986, “Early” breast-feeding jaundice: clinical significance, J.Pediatr., 108:156–158.

    Article  CAS  Google Scholar 

  12. Lepage, G. and Roy, C.C. 1988, Fecal bile acids as a means of assessing the integrity of the enterohepatic circulation of bile acids and their microbial degradation, J.Pediatr.Gastroenterol.Nutr., 7:6–19.

    Article  CAS  Google Scholar 

  13. Lester, R., St. Pyrek, J., Littler, J.M., and Adcock, E.W. 1983, Diversity of bile acids in the fetus and newborn infant, J.Pediatr.Gastroenterol.Nutr., 2:335–364.

    CAS  Google Scholar 

  14. Poland, R.L. and Odell, G.B. 1971, Physiologic jaundice; the enterohepatic circulation of bilirubin, N.Engl.Med., 284:1–6.

    Article  CAS  Google Scholar 

  15. Poland, R.L., Schultz, G.E., and Garg, G. 1980, High milk lipase activity associated with breast milk jaundiced infants, Pediatr.Res., 14:1328–1331.

    Article  CAS  Google Scholar 

  16. Ross, S.G., Waugh, T.R., and Malloy, H.T. 1937, The metabolism and excretion of bile pigment in icterus neonatorum, J.Pediatr., 11:397–404.

    Article  Google Scholar 

  17. Setchell, K.D.R. 1983, Liquid-solid extraction, lipophilic gel chromatography and capillary column gas chromatography in the analysis of bile acids form biological samples, in: “Bile Acids in Gastroenterology”, Dowling, R.H., Hofmann, A.F. and Roda, E., eds., MTP Press, Boston, pp. 1–18.

    Chapter  Google Scholar 

  18. Setchell, K.D.R. and Worthington, J. 1982, A rapid method for the quantitative extraction of bile acids and their conjugates from serum using commerically available reversed-phase octadecylsilane bonded silica cartridges, Clin.Chim.Acta, 125:135–144.

    Article  CAS  Google Scholar 

  19. Shackelton, C.H.L. and Whitney, J.O. 1980, Use of Sep-pak cartridges for urinary steroid extraction: evaluation of the method for use prior to gas Chromatographic analysis, Clin. Chim.Acta, 107:231–243.

    Article  Google Scholar 

  20. Siegenthaler, W. 1986, “Klinische Pathophysiologie”, Georg Thieme Verlag, Stuttgart.

    Google Scholar 

  21. van den Ende, A., Rädecker, C.E., Mairuhu, W.M., and van Zanten, A.P. 1982, Improved extraction procedures for determination of bile acids in faeces, Clin. Chim.Acta, 121:95–109.

    Article  Google Scholar 

  22. Yamada, M., Tazawa, Y., and Nakagawa, M. 1985, Alterations of serum bile acid profile in breastfed infants with prolonged jaundice, J.Pediatr.Gastroenterol.Nutr., 4:741–745.

    Article  CAS  Google Scholar 

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© 1994 Springer Science+Business Media New York

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Demirkol, M., Bohles, H. (1994). Breast Milk Taurine and its Possible Influence on the Development of Breast Milk Induced Jaundice of the Neonate — A Hypothesis. In: Huxtable, R.J., Michalk, D. (eds) Taurine in Health and Disease. Advances in Experimental Medicine and Biology, vol 359. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1471-2_42

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  • DOI: https://doi.org/10.1007/978-1-4899-1471-2_42

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1473-6

  • Online ISBN: 978-1-4899-1471-2

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