Abstract
Ozone (O3) is one of the six major air pollutants for which National Ambient Air Quality Standards have been designated under the Clean Air Act (8). Ozone is the most prevalent photochemical oxidant and an important component of “smog”. Ozone has been demonstrated to elicit the release of bronchoactive chemical mediators and to induce inflammation in the lungs of various species, including humans. Although the precise mechanism(s) of lung injury induced by O3 is unknown, this oxidant gas may interact directly with tissues, can generate free radicals, and clearly produces a lung inflammatory response.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Banks, M.A., Porter, D.W., Martin, W.G., and Castranova, V., 1991, Ozone-induced lipid peroxidation and membrane leakage in isolated rat alveolar macrophages: protective effects of taurine, J. Nutr. Biochem. 2:308–313.
Banks, M.A., Porter, D.W., Martin, W.G., and Castranova, V., 1990, Effects of in vitro ozone exposure on peroxidative damage. Membrane damage, leakage, and taurine contents of rat alveolar macrophages, Tox. Appl. Pharmacol. 105:55–65.
Chow, C.K., Hussain, M.Z., Cross, CE., Dungworth, D.L., and Mustafa, M.G., 1976, Effect of low levels of ozone on rat lungs, J. Biochemical responses during recovery and reexposure, Exp. Mol. Pathol. 25:182–188.
Crapo, J.D., Barry, B.E., Foscue, H. A., and Shelburne, J., 1980, Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen, Amer. Rev. Rspir. Dis. 122:123–143.
Ding, A., Nathan, C.F., and Stuehr, D.J., 1988, Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages, J. Immunol. 141:2407–2412.
Fukuda, K., Hirai, Y., Yoshida, H., Hakajima, T., and Usii, T., 1982, Free amino acid content of lymphocytes and granulocytes compared, Clin. Chem. 28:1758–1761.
Gordon, R.E., Snaked, A.A., and Solano, D.F., 1986, Taurine protects hamster bronchiols from acute NO2-induced alteration, Am. J. Path. 125:585–600.
Green, T., Fellman, J.H., Eicher, A.L., and Pratt, K.J., 1991, Anti-oxidant role and subcellular location of hypotaurine and taurine in human neutrophils, Biochem. Biophys. Acta, 1073:91–97.
Grisham, M.B., Jefferson, M.M., Melton, D.F., and Thomas, E.L., 1984, Chlorination of endogenous amines by isolated neutrophils, J. Biol. Chem. 259:10404–10413.
Kroencke, K.D., Kolb-Bachofen, V., Berschick, B., Burkhart, V., and Kolb, H., 1991, Activated macrophages kill pancreatic syngeneic isolet cells via arginine-dependent nitric oxide generation, Biochem. Biophy. Res. Comm. 175:752–758.
Learn, D.B., Fried, V.A., and Thomas, E.L., 1990, Taurine and hypotaurine contents of human leukocytes, J. Leuko. Biol. 48:174–182.
Mustafa, M.G., and Tierney, D.F., 1978, Biochemical and metabolic changes in the lung with oxygen, ozone, and nitrogen dioxide toxicity, Amer. Rev. Respir. Dis. 118:1061–1090.
Park, E., Quinn, M., Wright, C., and Schuller-Levis, G., 1993, Taurine chloramine inhibits the synthesis of nitric oxide and the release of tumor necrosis factor in activated RAW 264.7 cells, J. Leuk. Biol. 54:119–224.
Pendino, K., Punjabi, C., Gardner, C., Laskin, J., and Laskin, D., 1992 Ozone-induced alteration in reactive nitrogen and oxygen intermediate production by rat alveolar macrophages, Toxicologist 12:291 (abstract).
National Research Council, 1991, Rethinking the ozone problem in urban and regional air pollution. National Academy Press, Washington D.C.
Wang, Q.J., Giri, S.N., Hyde, D.M., and Li, C., 1991, Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taurine and niacin, Biochem. Pharmacol. 42:1115–1122.
Wang, Q. J., Hollinger, M. A., and Giri, S. N., 1992, Attenuation of amiodarone-induced lung fibrosis and phopholipidosis in hamsters by taurine and/or niacin treatment, J. Pharmacol. Exp. Ther. 262:127–132.
Wang, Q.J., Giri, S.N., Hyde, D.M., and Nakashima, J.M., 1989, Effects of taurine on bleomycininduced lung fibrosis in hamsters, Proc. Soc. Exp. Biol. Med. 190:330–338.
Witko, V., Nguyen, A.T., and Descamp-Latscha, B., 1992, Microtiter plate assay for phagocyte-derived taurine chloramines, J. Clin. Lab. Anal. 6:47–53.
Wright, C.E., Lin, T.T., Lin, Y.Y., Sturman, J., and Gaull, G., 1985, Taurine scavenges oxidized chlorine in biological systems, Prog. Clin. Biol. Res. 179:113–123.
Zglicznski, J.M., Selvaraj, R.J., Paul, B.B., Stelmaszynska, T., Poskitt, P.K.F., and Sbarra, A.J., 1977, Chlorination by the myeloperoxidase-H202-Cl antimicrobial system at acid and neutral pH, Proc. Soc. Exp. Biol. Med. 154:418–422.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Schuller-Levis, G., Quinn, M.R., Wright, C., Park, E. (1994). Taurine Protects against Oxidant-Induced Lung Injury: Possible Mechanism(s) of Action. In: Huxtable, R.J., Michalk, D. (eds) Taurine in Health and Disease. Advances in Experimental Medicine and Biology, vol 359. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1471-2_4
Download citation
DOI: https://doi.org/10.1007/978-1-4899-1471-2_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-1473-6
Online ISBN: 978-1-4899-1471-2
eBook Packages: Springer Book Archive