Skip to main content

Developmental Effects of Taurine Depletion on Synaptosomal Phospholipids in the Rat

  • Chapter
Taurine in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 359))

Abstract

No one working with taurine doubts its biological significance. Evidence continues to accumulate as to its fundamental involvement in phenomena as diverse as calcium homeostasis, osmoregulation, and membrane stabilization. The actions of taurine on these phenomena are, perhaps, interrelated. It continues to be a puzzle, however, as to why, if taurine is important for cell function, its concentration in cognate structures varies so much from species to species, or even temporally within a given species. Taurine concentrations in the heart, for example, can vary, depending on the species, over a tenfold range (10). Synaptosomal taurine concentrations in the rat can vary sixfold, depending on the developmental stage of the brain (14,23).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cantafora, A., Mantovani, A., Masella, R., Mechelli, L., and Alvaro, D. 1986, Effect of taurine administration on liver lipids in guinea pigs, Experientia, 42:407–408.

    Article  CAS  Google Scholar 

  2. Christiansen, K. 1975, Lipid extraction procedure for in vitro studies of glyceride synthesis with labeled fatty acid, Anal.Biochem., 66:93–99.

    Article  CAS  Google Scholar 

  3. Crews, F. 1985, Phospholipid methylation and membrane function, in: “Phospholipids and Cellular Regulation, Vol. I”, Kuo, K.F., ed., CRC Press, Boca Raton, Florida, pp. 131–158.

    Google Scholar 

  4. Crews, F.T., Hirata, F., and Axelrod, J. 1980, Identification and properties of methyltransferases that synthesize phosphatidylcholine in rat brain synaptosomes, J. Neurochem., 34:1491–1498.

    Article  CAS  Google Scholar 

  5. Dyer, J.R. and Greenwood, C.E. 1988, Evidence for altered methionine methyl-group utilization in the diabetic rat’s brain, Neurochem. Res., 13:517–523.

    Article  CAS  Google Scholar 

  6. Gray, E.G. and Whittaker, V.P. 1962, The isolation of nerve endings from brain: an electron microscopic study of cell fragments derived by homogenization and centrifugation, J.Anat., 96:79–88.

    CAS  Google Scholar 

  7. Green, D.E., Mii, S., and Kohout, P.M. 1955, Studies on the terminal electron transport system: I. Succinate dehydrogenase, JBC, 217:551–567.

    CAS  Google Scholar 

  8. Hamaguchi, T., Azuma, J., and Schaffer, S. 1991, Interaction of taurine with methionine: Inhibition of myocardial phospholipid methyltransferase, J. Cardiovasc.Pharmacol., 18:224–230.

    Article  CAS  Google Scholar 

  9. Huxtable, R. and Bressler, R. 1973, Determination of orthophosphate, Anal.Biochem., 57:604–608.

    Article  Google Scholar 

  10. Huxtable, R.J. 1976, Metabolism and function of taurine in the heart, in: “Taurine”, Huxtable, R.J. and Barbeau, A., eds., Raven Press, New York, pp. 99–119.

    Google Scholar 

  11. Huxtable, R.J. 1987, From heart to hypothesis: a mechanism for the calcium modulatory actions of taurine, in: “The Biology of Taurine: Methods and Mechanisms”, Huxtable, R.J., Franconi, F. and Giotti, A., eds., Plenum Press, New York, pp. 371–388.

    Chapter  Google Scholar 

  12. Huxtable, R.J. 1990, The interaction between taurine, calcium and phospholipids: Further investigations of a trinitarian hypothesis, in: “Taurine: Functional Neurochemistry, Physiology, and Cardiology”, Pasantes-Morales, H., Martin, D.L., Shain, W. and del Río, R.M., eds., Wiley-Liss, New York, pp. 185–196.

    Google Scholar 

  13. Huxtable, R.J. 1992, Physiological actions of taurine, Physiol.Rev., 72:101–163.

    CAS  Google Scholar 

  14. Huxtable, R.J., Crosswell, S., and Parker, D. 1989, Phospholipid composition and taurine content of synaptosomes in developing rat brain, Neurochem.International, 15:233–238.

    Article  CAS  Google Scholar 

  15. Huxtable, R.J., Laird, H.E., and Lippincott, S.E. 1979, The transport of taurine in the heart and the rapid depletion of tissue taurine content by guanidinoethyl sulfonate, Journal of Pharmacology and Experimental Therapeutics, 211:465–471.

    CAS  Google Scholar 

  16. Huxtable, R.J. and Peterson, A. 1988, The effect of taurine on calcium binding to brain synaptosomes, Pharmacologist, 30:A86.(Abstract).

    Google Scholar 

  17. Huxtable, R.J. and Peterson, A. 1989, Altered calcium binding induced by taurine in brain synaptosomal membranes, J.Neurochem., 52 (Supp.):S161 B.(Abstract).

    Google Scholar 

  18. Huxtable, R.J. and Sebring, L. 1987, Modulation by taurine of calcium binding to phospholipid vesicles and cardiac sarcolemma, Proc. Western Pharmacol. Soc., 30:153–155.

    CAS  Google Scholar 

  19. Huxtable, R.J. and Sebring, L.A. 1986, Towards a unifying theory for the action of taurine, Trends Pharmacol.Sci., 7:481–485.

    Article  CAS  Google Scholar 

  20. Huxtable, R.J. and Sebring, L.A. 1989, Taurine and the heart: the phospholipid connection, in: “Taurine and the Heart”, Iwata, H., Lombardini, J.B. and Segawa, T., eds., Kluwer Academic Press, Boston, pp. 31–42.

    Chapter  Google Scholar 

  21. Lleu, P.-L., Bowers, R., Gargano, A., Messing, J.M., Sturman, J., and Huxtable, R.J. 1994, Taurine depletion and synaptosomal phospholipid content in cat brain, in: “Taurine in Health and Disease”, Huxtable, R.J. and Michalk, D., eds., Plenum Press, New York, pp. in press.

    Google Scholar 

  22. Lleu, P.-L., Croswell, S., and Huxtable, R.J. 1992, Phospholipids, phospholipid methylation and taurine content in synaptosomes of developing rat brain, in: “Taurine: Nutritional Value and Mechanisms of Action”, Lombardini, J.B., Schaffer, S.W. and Azuma, J., eds., Plenum Publishing, New York, pp. 221–228.

    Google Scholar 

  23. Lleu, P.-L. and Huxtable, R.J. 1992, Phospholipid methylation and taurine content of synaptosomes from cerebral cortex of developing rat, Neurochem.International, 21:109–118.

    Article  CAS  Google Scholar 

  24. Lowry, O.J., Rosebrough, N.J., Farr, A.L., and Randall, R.J. 1951, Protein measurement with folin phenol reagent, J.Biol.Chem., 193:265–275.

    CAS  Google Scholar 

  25. McGivney, A., Crews, F.T., Hirata, F., Axelrod, J., and Siraganian, R.R. 1981, Rat basophilicleukemia cells defective in phospholipid methyltransferase enzyme, Ca2+ influx and histamine release: Reconstruction by hybridization, Proc.Natl.Acad.Sci. USA, 78:6176–6180.

    Article  CAS  Google Scholar 

  26. Okumura, K., Panagia, V., Beamish, R.E., and Dhalla, N.S. 1987, Biphasic changes in the sarcolemmal phosphatidylethanolamine N-methylation activity in catecholamine-induced cardiomyopathy, J.Mol.Cell.Cardiol., 19:356–366.

    Article  Google Scholar 

  27. Panagia, V., Elimban, V., Ganguly, P.K., and Dhalla, N.S. 1987, Decreased Ca2+ binding and Ca2+ ATPase activities in heart sarcolemma upon phospholipid methylation, Mol. Cell.Biochem., 78:65–71.

    Article  CAS  Google Scholar 

  28. Panagia, V., Makino, N., Ganguly, P.K., and Dhalla, N.S. 1987, Inhibition of Na+-Ca2+ exchange in heart sarcolemmal vesicles by phosphatidylethanolamineN-methylation, Eur. J.Biochem., 166:597–603.

    Article  CAS  Google Scholar 

  29. Parker, F. and Peterson, N.F. 1965, Quantitative analysis of phospholipids and phospholipid fatty acids from silica gel thin layer chromatograms, J.Lipid Res., 6:455–460.

    CAS  Google Scholar 

  30. Sebring, L.A. and Huxtable, R.J. 1986, Low affinity binding of taurine to phospholiposomes and cardiac sarcolemma, Biochim.Biophys.Acta, 884:559–566.

    Article  CAS  Google Scholar 

  31. Skipski, V.P., Peterson, R.F., and Barclay, M. 1964, Quantitative analysis of phospholipids by thin-layer chromatography, Biochem.J., 90:374–378.

    CAS  Google Scholar 

  32. Strittmatter, W.J., Hirata, F., and Axelrod, J. 1979, Phospholipid methylation unmasks cryptic α-adrenergic receptors in rat reticulocytes, Science, 204:1207–1209.

    Article  Google Scholar 

  33. Sun, G.Y. and Sun, A.Y. 1985, Ethanol and membrane lipids, Alcohol Clin.Exp.Res., 9:164–180.

    Article  CAS  Google Scholar 

  34. Tallman, J.F.J., Henneberry, R.C., Hirata, F., and Axelrod, J. 1979, Control of β-adrenergic receptors in Heia cells, in: “Catecholamines: Basic and Clinical Frontiers, Vol. I”, Usdin, E., Kopin, I.J. and Barchas, J., eds., Pergamon Press, pp. 489-491.

    Google Scholar 

  35. Whittaker, V.P. and Barker, L.A. 1972, The subcellular fractionation of brain tissue with special reference to the preparation of synaptosomes and their component organelles, in: “Methods in Neurochemistry, Volume II”, Fried, R., ed., Marcel Dekker, NY, pp. 1-52.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Huxtable, R.J., Murphy, J., Lleu, PL. (1994). Developmental Effects of Taurine Depletion on Synaptosomal Phospholipids in the Rat. In: Huxtable, R.J., Michalk, D. (eds) Taurine in Health and Disease. Advances in Experimental Medicine and Biology, vol 359. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1471-2_35

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-1471-2_35

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1473-6

  • Online ISBN: 978-1-4899-1471-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics