Abstract
Taurine is essential to the normal development of the mammalian brain (31). A deficiency of taurine is associated with arrested cell migration in the developing cerebellum in kittens (32, 33) and weaver mice (24, 34) and with morphological abnormalities in the visual cortex of cats during development (35). The role of taurine in development of many other brain structures, however, remains to be elucidated. Taurine concentrations in the brain are four- to six-fold higher in the neonate than in the adult and decline to adult concentrations by 40–50 days post-natal (1, 19, 20, 21, 30, 31). It is unclear, in many brain regions, whether this decline is due to a decrease in concentration within the same cells that contain taurine during adulthood or whether there is a change in localization during development. A localization of taurine in the neonate that differed from the localization in the adult brain would suggest that taurine plays different roles during development than during adulthood.
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© 1994 Springer Science+Business Media New York
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Magnusson, K.R. (1994). Changes in the Localization of Taurine-Like Immunoreactivity during Development and Regeneration in the Rat Brain. In: Huxtable, R.J., Michalk, D. (eds) Taurine in Health and Disease. Advances in Experimental Medicine and Biology, vol 359. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1471-2_24
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DOI: https://doi.org/10.1007/978-1-4899-1471-2_24
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