Abstract
DNA vaccines are nonreplicating plasmids encoding genes from pathogens. The antigenic proteins are thus expressed in the cells of the vaccinated host and result in the generation of both antibody and cell-mediated immune responses. The ability to generate proteins with native conformation contrasts with certain recombinant protein or inactivated viral vaccines, and offers the means to generate antibodies against the relevant epitopes. Because the desired proteins are synthesized within the host, cell-mediated immune responses can be generated, without the inherent risks of certain viral vectors or of attenuation of certain attenuated viruses (e.g., HIV) and bacteria.
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Ulmer, J.B. et al. (1996). DNA Vaccines for Bacteria and Viruses. In: Cohen, S., Shafferman, A. (eds) Novel Strategies in the Design and Production of Vaccines. Advances in Experimental Medicine and Biology, vol 397. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1382-1_7
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DOI: https://doi.org/10.1007/978-1-4899-1382-1_7
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