Skip to main content

HIV—Peplotion Vaccine

A Novel Approach to Vaccination against AIDS by Transepithelial Transport of Viral Peptides and Antigens to Langerhans Cells for Induction of Cytolytic T Cells by HLA Class I and CD1 Molecules for Long Term Protection

  • Chapter
Novel Strategies in the Design and Production of Vaccines

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 397))

Abstract

Two properties of the human immunodeficiency virus (HIV) make the control of HIV spread in the human population difficult: a) infection of T cells and dendritic cells and macrophages, the professional antigen-presenting cells and b) transmission from donor to recipient by HIV-1 -infected cells. The rapid spread of HIV infection in the human population in epidemic form was enhanced by the transmission of infected cells from infected individuals to non-infected partners as part of human sexual behavior, and due to exposure of intravenous drug users to infected syringes. Despite attempts to educate the human population in safe sexual behavior, the spread of HIV infection continues and the end of the HIV epidemic is not in sight.

UNESCO European Network “Man Against Virus.”

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Becker, Y., 1993, From the discovery of poliovirus vaccinia virus mRNAs and polyribosomes to computer analysis of HIV-1 and 2 glycoproteins, in Concepts in Virology (B.W.J. Mahy and D.K. Lvov, editors) pp 77-79, Hardwood Academic Publishers.

    Google Scholar 

  • Becker, Y, 1994a, HIV-1 proteins in infected cells determine the presentation of viral peptides by HLA class I and class II molecules and the nature of the cellular and humoral antiviral immune responses-a review, Virus Genes, 8:249–270.

    Article  PubMed  CAS  Google Scholar 

  • Becker, Y, 1994b, An analysis of the role of skin Langerhans cells (LC) in the cytoplasmic processing of HIV-1 peptide after “peplotion” transpidermal transfer and HLA class I presentation to CD8+ CTLs-an approach to immunization of humans, Virus Genes, 9:133–147.

    Article  Google Scholar 

  • Becker, Y, 1995, Computer simulations to predict the availability of peptides with known HLA class I motifs possibly generated by proteolysis of HIV-1 proteins in infected cells, Virus Genes 10:in press.

    Google Scholar 

  • Beckman, E.M., Porcelli, S.A., Morita, CT., Behar, S.M., Furlong, S., and Brenner, M.B., 1994, Recognition of a lipid antigen by CD1 restricted α/β+ T cells, Nature, 37: 691–694.

    Article  Google Scholar 

  • Bjorkman, P.J., Saper, M.A., Samaraoni, B., Bennet, W.S., Strominger, J.L., and Wiley, D.C., 1987, The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329:512–518, 1987.

    Article  PubMed  CAS  Google Scholar 

  • Bolognesi, D., 1994, Not Yet, it is too early to use a live attenuated virus vaccine against HIV-1, J. NIH Res. 6:55,59-62.

    Google Scholar 

  • Cameron, P.U., Mallal, S.A., French, M.A.H., and Dawkins, R.L. 1990, Central MHC genes between HLA-B and complement C4 confer risk for HIV-1 disease progression, Human Immunology 29:282–295.

    Article  PubMed  CAS  Google Scholar 

  • Choi, H.K., Flynn, G.L., and Amidon, G.G., 1994, Transdermal delivery of bioactive peptides: the effect of n-decylmethyl solfoxide, pH and inhibitors of enkephalin metabolism and transport, Pharm. Res. 7:1099–1106, 1990.

    Article  Google Scholar 

  • Desrosiers, R.C., 1994, Yes, it is time to consider use of a live-attenuated virus vaccine against HIV, J. NIH Res. 6:54,56-59.

    Google Scholar 

  • Haynes, B.F., 1993, Scientific and social issues of human immunodeficiency virus vaccine development, Science 260:1279–1286.

    Article  PubMed  CAS  Google Scholar 

  • McKinney, E.L., and Streilein, J.W., 1989, On the extraordinary capacity of allogeneic epidermal Langerhans cells to prime cytotoxic T cells in vivo, J. Immunol. 143:1560–1564.

    PubMed  CAS  Google Scholar 

  • Nair, S., Babu, J.S., Dunham, R.G., Kanda, P., Burke, R.L., and Rouse, B.T., 1993, Induction of primary, antiviral cytotoxic, and proliferative responses with antigens administered via dendritic cells, J. Virol. 67:4062–4069.

    PubMed  CAS  Google Scholar 

  • Porcelli, S., Brenner, M.B., Greenstein, J.L., Balk, S.P., Terhorst, C. and Bleicher, P.A., 1989, Recognition of cluster of differentiation 1 antigens by human CD4CD8 cytolytic T lymphocytes, Nature 341:447–450.

    Article  PubMed  CAS  Google Scholar 

  • Porcelli, S., Morita, C.T., and Brenner, M.B., 1992, CD1b restricts the response of human CD48 T lymphocytes to a microbial antigen, Nature 360:593–597.

    Article  PubMed  CAS  Google Scholar 

  • Rabinovich, N.R., Mclnnes, P., Klein, D.L., and Hall, B.F., 1994, Vaccine technologies: view to the future, Science 265:1401–1404.

    Article  PubMed  CAS  Google Scholar 

  • Reid, C.D.L., Fryer, PR., Clifford, C., Kirk, A., Tikerpae, J., and Knight, S.C., 1990, Identification of hematopoietic progenitors of macrophages and dendritic Langerhans cells (DL-CFU) in human bone marrow and peripheral blood, Blood 76:1139–1149.

    PubMed  CAS  Google Scholar 

  • Sabin, A.B., 1992, Improbability of effective vaccination agaoinst human immunodeficiency virus because of its intracellular transmission and rectal portal of entry, Proc. Natl. Acad. Sci. USA 89:8852–8855.

    Article  PubMed  CAS  Google Scholar 

  • Salk, J., Bretscher, P.A., Salk, PL., Clerici, M., and Shearer, G.M., 1993, A strategy for prophylactic vaccination against AIDS, Science 260:1270–1272.

    Article  PubMed  CAS  Google Scholar 

  • Schultz, M., Zinkernagel, R.M., and Hengartner, H., 1991, Peptide-induced antiviral protection by cytotoxic T cells, Proc. Natl. Acad. Sci. USA 88:991–993.

    Article  Google Scholar 

  • Takahashi, H., Takeshita, T., Morein, B., Putney, S., Germain, R.N., and Berzofsky, J.A., 1990, Induction of CD8+ cytotoxic T cells by imunization with purified HIV-1 envelope protein in ISCOMs, Nature 34:873–875.

    Article  Google Scholar 

  • Walker, C., Selby, M., Erickson, A., Do, D.C., Valensi, J-P, and Van Nest, G., 1992, Cationic lipids direct a viral glycoprotein into class I major histocompatibility complex antigen-presentation pathway, Proc. Natl. Acad. Sci. USA 89:7915–7918.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Becker, Y. (1996). HIV—Peplotion Vaccine. In: Cohen, S., Shafferman, A. (eds) Novel Strategies in the Design and Production of Vaccines. Advances in Experimental Medicine and Biology, vol 397. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1382-1_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-1382-1_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1384-5

  • Online ISBN: 978-1-4899-1382-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics