Skip to main content
SpringerLink
Log in

Bacterial Outer Membrane Protein Vaccines

The Meningococcal Example

  • Chapter
Novel Strategies in the Design and Production of Vaccines

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 397))

Abstract

With respect to bacterial vaccines, a number of approaches were found successful by way of empirical research, trial and error.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baehr, W, Zhang, Y. Z., Joseph, T., Su, H., Nano, F. E., Everett, K. D. E., Caldwell, H. D., 1988, Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane genes, Proc. Natl. Acad. Sci. USA, 85:4000–4004.

    Article  PubMed  CAS  Google Scholar 

  2. Bell, J., Grass, S., Jeanteur, D., Munson, R. S. Jr., Diversity of the P2 protein among nontypeable Haemophilus influenzae isolates, Inf. Immun. 62:2639–2643.

    Google Scholar 

  3. Bjune, G., Høiby, E. A., Grønnesby, J. K., Arnesen, Ø., Fredriksen, J. H., Halstenen, A., Holten, E., Lindbak, A. K., Nøkleby, H., Rosenqvist, E, Solberg, L. K., Closs, O., Eng, J., Frøholm, L. O., Lystad, A., Bakketeig, L. S., Hareide, B., 1991, Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway, Lancet 338:1093–1096.

    Article  PubMed  CAS  Google Scholar 

  4. Brugghe, H. F., Timmermans, J. A. M., Van Unen, L. M. A., Ten Hove, G. J., Van de Werken, G., Poolman, J. T. and Hoogerhout, P., 1994, Simultaneous multiple synthesis and selective conjugation of head-to-tail cyclized peptides, derived from a surface-loop of a meningococcal class 1 outer membrane protein, Int. J. Pept. Prot. Res. 43:166–172.

    Article  CAS  Google Scholar 

  5. Cassio de Moraes, J., Perkins, B.A., Camargo, M.C.C., Rossetto Hidaldo, N.T., Aparecida Barbosa, H., Tavares Sacchi, C., Landgraf, I. M., Gattas, V. L., Vascondcelos, H. de G., Plihaytis, B. D., Wenger, J. D., Broome, C. V, 1992, Protective efficacy of a serogroup B meningococcal vaccine in Sao Paulo, Brazil, Lancet 340:1074–1078.

    Article  Google Scholar 

  6. Christodoulides, M., McGuinness, B. T., Heckels, J. E., 1993, Immunization with synthetic peptides containing epitopes of the class 1 outer membrane protein of Neisseria meningitidis: production of bactericidal antibodies on immunization with a cyclic peptide, J. Gen. Microbiol. 139:1729–1738.

    Article  PubMed  CAS  Google Scholar 

  7. Christodoulides, M., Heckels, J.E., 1994, Immunization with a multiple antigen peptide containing defined B-and T-cell epitopes: production of bactericidal antibodies against group B Neisseria meningitidis, Microbiology 240:2951–2960.

    Article  Google Scholar 

  8. Claassen, I., Meylis, J., Van der Ley, P., Peeters, C., Brons, H., Robert, J., Borsboom, D., Van der Ark, A., Van Straaten, I., Roholl, P., Kuipers, B., Poolman, J., Production, characterization and control of a hexavalent Class 1 Outer Membrane protein containing vesicle vaccine made from tailor-made Neisseria meningitidis strains, Vaccine submitted.

    Google Scholar 

  9. Conlan, J. W., Clarke, I. N., Ward, M. E., 1988, Epitope mapping with solid-phase peptides: identification of type-, subspecies-, species-and genus-reactive antibody binding domains on the major outer membrane protein of Chlamydia trachomatis, Mol. Microbiol. 2:673–679.

    Article  PubMed  CAS  Google Scholar 

  10. Cowan, S. W., Schirmer, T., Rummel, G., Steiert, M., Ghosh, R., Pauptit, R. A., Jansonius, J. N., Rosenbusch, J. P., 1992, Crystal structures explain functional properties of two E.coli porins, Nature, 358:727–733.

    Article  PubMed  CAS  Google Scholar 

  11. Fredriksen, J. H., Rosenqvist, E., Wedege, E., Bryn, K., Bjune, G., Froholm, L. O., Lindbak, A. K., Møgster, B., Namork, E., Rye, U., Stabbetorp, G, Winsnes, R., Aase, B., Closs, O., 1991, Production, characterization and control of MenB-vaccine helsa: an outer membrane vesicle vaccine against group B meningococcal disease, NIPH annals 14:67–80.

    PubMed  CAS  Google Scholar 

  12. Frontiers in medicine: Vaccines, 1994, Science 265:1371-1404.

    Google Scholar 

  13. Gilleland, H. E. Jr., Parker, M. G., Matthews, J. M., Berg, R.D., 1984, Use of a purified outer membrane protein F (porin) preparation of Pseudomonas aeruginosa as a protective vaccine in mice, Inf. Immun. 44:49–54.

    CAS  Google Scholar 

  14. Haase, E. M., Yi, K., Morse, G. D., Murphy, T. F., 1994, Mapping of bactericidal epitopes of the P2 porin protein of nontypeable Haemophilus influenzae, Inf. Immun. 62:3712–3722.

    CAS  Google Scholar 

  15. Helminen, M. E., Maciver, I., Latimer, J. L., Cope, L. D., McCracken, G. M. Jr., Hansen, E. J., 1993, A major outer membrane protein of Moraxella catarrhalis is a target for antibodies that enhance pulmonary clearance of the pathogen in an animal model, Inf. Immun. 61:2003–2010.

    CAS  Google Scholar 

  16. Hoogerhout P., Donders, E. M. L. M., Van Gaans-van den Brink, J. A. M., Kuipers, B, Brugghe, H. F., Van Unen, L. M. A., Timmermans, H., Ten Hove, G. J., De Jong, A. P. J. M., Peeters, C. C. A. M., Wiertz, E. J. H. J., Poolman. J. T., Conjugates of synthetic cyclic peptides elicit bactericidal antibodies against a conformational epitope on a class 1 outer membrane protein of Neisseria meningitidis, Inf. Immun. 63: 3473.3478.

    Google Scholar 

  17. Horwitz M. A., Lee, B. W. E., Dillon, B. J., Harm, G., 1995, Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis, Proc. Natl. Acad. Sci. USA 92:1530–1534.

    Article  PubMed  CAS  Google Scholar 

  18. Idänpään-Heikkilä, I., Muttilainen, S., Wahlström, Saarinen, L., Leinonen, M., Sarvas, M., Mäkelä, P. H., The antibody response to a prototype liposome vaccine containing Neisseria meningitidis outer membrane protein P1 produced in Bacillus subtilis, Vaccine in press.

    Google Scholar 

  19. Isibasi, A., Ortiz-Navarrete, V, Paniagua, J., Pelayo, R., Gonzalez, C. R., Garcia, J. A., Kumate, J., 1992, Active protection of mice against Salmonella typhi by immunization with strain-specific porins, Vaccine 10:811–813.

    Article  PubMed  CAS  Google Scholar 

  20. Lissolo, L., Maitre-Wilmotte, G., Dumas, P., Mignon, M., Danve, B., Quentin-Millet, M. J., 1995, Evaluation of transferrin-binding protein complex as a potential antigen for future meningococcal vaccines, Inf. Immun., 63:884–900.

    CAS  Google Scholar 

  21. Pettersson, A., Kuipers, B., Pelzer, M., Verhagen, E. P. M., Tiesjema, R. H., Tommassen, J., Poolman, J. T., 1990, Monoclonal antibodies against the 70-kilodalton iron-regulated protein of Neisseria meningitidis are bactericidal and strain-specific, Infect. Immun. 58:3036–3041.

    PubMed  CAS  Google Scholar 

  22. Petterson, A., Van der Ley, P. A., Poolman, J. T., Tomassen, J., 1993, Molecular characterization of the 98kDa non-regulated outer membrane protein of Neisseria meningitidis, Inf.Immun. 61:4724–4733.

    Google Scholar 

  23. Poole, E., Lamont, I., 1992, Serovar differentiation of Chlamydia trachomatis by direct sequence analysis of the variable segment 4 region of the major outer membrane protein gene, Inf. Immun. 60:1089–1094.

    CAS  Google Scholar 

  24. Poolman, J. T., Hamstra, H. J., Barlow, A. K., Kuipers, A. J., Loggen, H., Nagel, J., 1990, Outer membrane vesicles of Bordetella pertussis are protective antigens in the mouse intracerebral challenge model. In: Manclark, C.R.(ed.). Proc. VI International Pertussis Symposium, US Public Health Service, Bethesda, Maryland, DHHSPubl. no. (FDA)90-1164, pp 148–156.

    Google Scholar 

  25. Poolman, J. T., Van der Ley, P. A., Wiertz, E. J. H. J., Hoogerhout, P., 1991, Second generation meningococcal OMP-LPS vaccines, NIPH Annuals 14:233–241.

    CAS  Google Scholar 

  26. Poolman, J. T., 1995, Development of a meningococcal vaccine, Infect. Agents Dis. 4:13–28.

    PubMed  CAS  Google Scholar 

  27. Poolman, J. T., Van der Ley, P. A., Tomassen, J., 1995, Surface structures and secreted products of meningococci, In: Meningococcal Disease, Publ. John Wiley & Sons, Ed. K. Cartwright; pp 21-34.

    Google Scholar 

  28. Rappuoli, R., Pizza, M., Podda, A., 1991, Towards third-generation whooping cough vaccines, Tibtech. 9:232–238.

    Article  CAS  Google Scholar 

  29. Roy, S., Das, A. B., Ghosh, A. N., Biswas, T., 1994, Purification, pore-forming ability, and antigenic relatedness of the major outer membrane protein of Shigella dysenteride type 1, Inf. Immun. 62:433–4338.

    Google Scholar 

  30. Sikkema, D. J., Murphy, T. F., 1992, Molecular analysis of the P2 porin protein of nontypeable Haemophilus influenzae. Inf. Immun. 60:5204–5211.

    CAS  Google Scholar 

  31. Skrikumar, R., Dahan, D., Gras, M. F., Ratcliffe, M. J. H., van Alphen, L., Coulton, J. W., 1992, Antigenic sites on porin of Haemophilus influenzae type b: mapping with synthetic peptides and evaluation of structure presictions, J. Bacteriol. 174:4007–4016.

    Google Scholar 

  32. Sonntag, I., Schwartz, H., Hirota, Y, Henning, U., 1978, Cell envelope and shape of Esscherichia coli: multiple mutants missing the outer membrane lipoprotein and other major outer membrane proteins, J. Bacteriol 136:280–285.

    PubMed  CAS  Google Scholar 

  33. Van der Ley, P. A., Heckels, J. E., Virji, M., Hoogerhout, P., Poolman J. T., 1991, Topology of outermembrane porins in pathogenic Neisseria spp, Infect. Immun. 59:2963–2971.

    PubMed  Google Scholar 

  34. Van der Ley, P. A., Poolman, J. T., 1992, Construction of multivalent class 1 OMP expressing meningococcal vaccine strain, Infect. Immun, 60:3156–3161.

    Google Scholar 

  35. Van der Ley, P., Van der Biezen, J., Peeters, C. C. A. M., Poolman, J. T., 1993, Use of transformation to construct antigenic hybrids of the class 1 outer membrane protein in Neisseria meningitidis, Inf. Immun. 61:4724–4733.

    Google Scholar 

  36. Van der Ley, P. A., Van der Biezen, J., Poolman, J. T, 1995, Construction of Neisseria meningitidis strains carrying multiple chromosomal copies of the porA gene for use in the production of a multivalent outer membrane vesicle vaccine, Vaccine 13:401–407.

    Article  PubMed  CAS  Google Scholar 

  37. Wetzler, L. M., Blake, M. S., Barry, K., Gotschlich, E. C., 1992, Gonococcal porin vaccine evaluation: comparison of Por proteosomes, liposomes, and blebs isolated from rmp deletion mutants, J. Infect. Dis., 166:551–555.

    Article  PubMed  CAS  Google Scholar 

  38. Wiertz, E.J.H.J., Van Gaans-van den Brink, J.A.M., Gausephol, H., Prochnicka-Chalufour, A., Hoogerhout, P., Poolman, J.T., 1992, Identification of T cell epitopes occurring in a meningococcal class 1 outer membrane protein using overlapping peptides assembled with simultaneous multiple peptide synthesis, J.Exp.Med, 176:79–88.

    Article  PubMed  CAS  Google Scholar 

  39. Zhong, G., Berry, J., Brunham, R. C., 1994, Antibody recognition of a neutralization epitope on the major outer membrane protein of Chlamydia trachomatis, Inf. Immun. 62:1576–1583.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Vaccine Development and Immune Mechanisms, National Institute of Public Health and Environmental Protection (RIVM), Antonie van Leeuwenhoeklaan 9, P.O. Box 1, 3720 BA, Bilthoven, The Netherlands

    Jan T. Poolman

Authors
  1. Jan T. Poolman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Israel Institute for Biological Research, Ness-Ziona, Israel

    Sara Cohen  & Avigdor Shafferman  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Poolman, J.T. (1996). Bacterial Outer Membrane Protein Vaccines. In: Cohen, S., Shafferman, A. (eds) Novel Strategies in the Design and Production of Vaccines. Advances in Experimental Medicine and Biology, vol 397. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1382-1_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-1382-1_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1384-5

  • Online ISBN: 978-1-4899-1382-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation