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Chemistry and Biological Activity of AAL Toxins

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Fumonisins in Food

Part of the book series: Advances in Experimental medicine and Biology ((AEMB,volume 392))

Abstract

AAL toxins and fumonisins comprise a family of highly reactive, chemically related mycotoxins that disrupt cellular homeostasis in both plant and animal tissues. Two critical issues to resolve are the detection of the entire family in food matricies and the mode of cellular disruption. Analysis of the entire set of chemical congeners in food matrices is difficult but has been achieved by a combination of different HPLC and mass spectrometry strategies. The mode of cellular disruption is unknown but likely involves changes associated with the inhibition of ceramide synthase in both plants and animals. Toxin treated cells exhibit morphological and biochemical changes characteristic of apoptosis. Further evaluation of the specific genetic and biochemical changes that occur during toxin-induced cell death may aid in understanding the mole of the action of these mycotoxins.

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Author information

Authors and Affiliations

  1. Department of Food Science and Technology, University of California, Davis, Davis, CA, 95616, USA

    Carl K. Winter

  2. CEPRAP and Department of Plant Pathology, University of California, Davis, Davis, CA, 95616, USA

    David G. Gilchrist

  3. Department of Plant Pathology, University of Nebraska, Lincoln, Lincoln, NE, 68583, USA

    Martin B. Dickman

  4. Department of Veterinary and Biomedical Science and The Center for Biotechnology, University of Nebraska, Lincoln, Lincoln, NE, 68583, USA

    Clinton Jones

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  1. Carl K. Winter
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  2. David G. Gilchrist
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  3. Martin B. Dickman
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  4. Clinton Jones
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Editor information

Editors and Affiliations

  1. Food and Drug Administration, National Center for Food Safety and Technology, Summit-Argo, Illinois, USA

    Lauren S. Jackson

  2. General Mills, Inc., Minneapolis, Minnesota, USA

    Jonathan W. DeVries

  3. University of Nebraska-Lincoln, Lincoln, Nebraska, USA

    Lloyd B. Bullerman

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© 1996 Springer Science+Business Media New York

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Winter, C.K., Gilchrist, D.G., Dickman, M.B., Jones, C. (1996). Chemistry and Biological Activity of AAL Toxins. In: Jackson, L.S., DeVries, J.W., Bullerman, L.B. (eds) Fumonisins in Food. Advances in Experimental medicine and Biology, vol 392. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1379-1_26

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  • DOI: https://doi.org/10.1007/978-1-4899-1379-1_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1381-4

  • Online ISBN: 978-1-4899-1379-1

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