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Hepatotoxicity and -Carcinogenicity of the Fumonisins in Rats

A Review Regarding Mechanistic Implications for Establishing Risk In Humans

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Fumonisins in Food

Part of the book series: Advances in Experimental medicine and Biology ((AEMB,volume 392))

Abstract

Cancer induction by the non-genotoxic mycotoxin, fumonisin B1, has been investigated by studying the mechanisms involved during cancer initiation and promotion in rat liver. Cancer initiation is effected through a toxic-proliferative response while the inhibitory effect on hepatocyte cell proliferation appears to be a key aspect determining cancer promotion. Dose-response effects of the fumonisins on the induction of early neoplastic lesions in both long- and short-term animal experiments have been established. The biphasic response of FB1 on hepatocyte proliferation will be discussed in relation to the known mechanisms of cancer induction by the genotoxic hepatocarcinogens. Recent investigations regarding the effect of the fumonisins on lipid biosynthesis and its inhibitory effect on hepatocyte growth stimulatory responses in vitro will be highlighted. Integration of our current knowledge regarding the carcinogenic potential of the fumonisins in setting a realistic and applicable risk assessment model for this non-genotoxic carcinogen will finally be addressed.

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Authors and Affiliations

  1. Programme on Mycotoxins and Experimental Carcinogenesis, P.O. Box 19070, Tygerberg, 7505, South Africa

    W. C. A. Gelderblom, S. D. Snyman, S. Abel, S. Lebepe-Mazur, C. M. Smuts, L. Van der Westhuizen & W. F. O. Marasas

  2. National Research Programme for Nutritional Intervention, P.O. Box 19070, Tygerberg, 7505, South Africa

    C. M. Smuts

  3. Department of Medical Physiology and Biochemistry, MRC Centre for Molecular and Cellular Biology, University of Stellenbosch Medical School, P.O. Box 19063, Tygerberg, 7505, South Africa

    T. C. Victor

  4. Institut für Tumorbiologie-Krebsforschung, Universität Wien, Borschkegasse 8a, A-1090, Vienna, Austria

    S. Knasmüller & W. Huber

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  1. W. C. A. Gelderblom
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  2. S. D. Snyman
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  3. S. Abel
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  4. S. Lebepe-Mazur
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  5. C. M. Smuts
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  6. L. Van der Westhuizen
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  7. W. F. O. Marasas
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  8. T. C. Victor
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  9. S. Knasmüller
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  10. W. Huber
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Editor information

Editors and Affiliations

  1. Food and Drug Administration, National Center for Food Safety and Technology, Summit-Argo, Illinois, USA

    Lauren S. Jackson

  2. General Mills, Inc., Minneapolis, Minnesota, USA

    Jonathan W. DeVries

  3. University of Nebraska-Lincoln, Lincoln, Nebraska, USA

    Lloyd B. Bullerman

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Gelderblom, W.C.A. et al. (1996). Hepatotoxicity and -Carcinogenicity of the Fumonisins in Rats. In: Jackson, L.S., DeVries, J.W., Bullerman, L.B. (eds) Fumonisins in Food. Advances in Experimental medicine and Biology, vol 392. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1379-1_24

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  • DOI: https://doi.org/10.1007/978-1-4899-1379-1_24

  • Publisher Name: Springer, Boston, MA

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