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Fusaric Acid and Pathogenic Interactions of Corn and Non-Corn Isolates of Fusarium moniliforme, a Nonobligate Pathogen of Corn

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Book cover Fumonisins in Food

Part of the book series: Advances in Experimental medicine and Biology ((AEMB,volume 392))

Abstract

Fusarium moniliform is a nonobligate parasite of corn, which exists as a complex of closely related fungi from different mating population or biological species. Strains of this fungus isolated from corn, have been determined to belong to mating populations A, although other populations have been isolated from corn. The ultrastructural association of the fungus with corn during growth, and the effects of the host on suppression of disease suppression are reviewed. This fungus enters a relationship with corn cultivars that is not always pathogenic. Pathogenesis is delayed, if it ever occurs. F. moniliforme can exist entirely as an endophyte, systemically colonizing kernels, remaining there until germination upon which the fungus infects the emerging seedlings. The symptomless association persists during the growth cycle of corn, and the resulting endophytic hyphae may be the source of mycotoxin production. The host’s ability to suppress the fungus appears to be related to one class of compounds, the cyclic hydroxamic acids and their decomposition products, which can be catabolized by the fungi of mating population A but not C.

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References

  • Backmann, E. Der einfluss von fusarinsaure auf die wasserpermeabilitat von pflanzlichen protoplasten. Phytopath. Z. 1956, 27, 255–288.

    Google Scholar 

  • Bacon, C. W.; Bennett, R. M.; Hinton, D. M.; Voss, K. A. Scanning electron microscopy of Fusarium moniliforme within asymptomatic corn kernels and kernels associated with equine leukoencephalomalacia. Plant Dis. 1992, 76, 144–148.

    Article  Google Scholar 

  • Bacon, C. W.; Nelson, P. E. Fumonisin production in corn by toxigenic strains of Fusarium moniliforme and Fusarium proliferatum. J. Food Protec. 1994, 57, 514–521

    CAS  Google Scholar 

  • Bacon, C. W.; Hinton, D.M; Richardson, M. D. A corn seedling test for resistance to Fusarium moniliforme. Plant Dis. 1994, 78, 302–305.

    Article  Google Scholar 

  • Bacon, C. W.; Porter, J. K.; Norred, W. P. Toxic interaction of fumonisin B1 and fusaric acid measured by injection into fertile chicken eggs. Mycopathologia 1995, 129, 29–35.

    Article  CAS  Google Scholar 

  • Bjeldanes, L. F.; Thomson, S. V. Mutagenic activity of Fusarium moniliforme isolates in the Salmonella typhimurium assay. Appl. Environ. Microbiol. 1979, 37, 1118–1121.

    CAS  Google Scholar 

  • Booth, C. The Genus Fusarium. Commonwealth Mycological Institute: Kew, Surrey, England 1971.

    Google Scholar 

  • Bracker, C. E. Ultrastructure of fungi. Ann. Rev. Phytopathol. 1967, 5, 343–374.

    Article  Google Scholar 

  • Bracker, C. E.; Littlefield, L. J. Structural concepts of host-pathogen interfaces. In Fungal Pathogenicity and the Plant’s Response; Byrde, R.J.W. Cutting, C.V., Eds.; Academic Press: New York, 1973; pp 159–317.

    Google Scholar 

  • Braun, R. Uber Wirkungsweise und Umwandlungen der fusarinsaure. Phytopath. Z. 1960, 39, 197–241.

    Article  Google Scholar 

  • Cheng, S. J.; Jiang, Y. Z.; Li, M. H.; Lo, H. Z. A mutagenic metabolite produced by Fusarium moniliforme isolated from Linxian county, China. Carcinogenesis 1985, 6, 903–905.

    Article  CAS  Google Scholar 

  • Chu, F. S.; Huang, X.; Maragos, C. M. Production and characterization of anti-idiotype and anti-anti-idiotype antibodies against fumonisin B1. J. Agric. Food Chem. 1995, 43, 261–267.

    Article  CAS  Google Scholar 

  • Cole, R. J.; Kieksey, J. W.; Cutler, H. G.; Doupnik, B. L.; Peckham, J. C. Toxin from Fusarium moniliforme: Effects on plants and animais. Science 1973, 179, 1324–1326.

    Article  CAS  Google Scholar 

  • Cook, R. J. Water relations in the biology of Fusarium. In Fusarium: Diseases, Biology, and Taxonomy, Nelson, P. E.; Toussoun, T. A.; Cook, R. J., Eds.; The Pennsylvania State University Press: University Park, 1981; pp 236–244.

    Google Scholar 

  • Davis, D. Fusaric acid in selective pathogenicity. Phytopathology 1969, 59, 1391–1395.

    CAS  Google Scholar 

  • De Leon, C.; Pandey, S. Improvement of resistance to ear and stalk rot and agronomic traits in tropical maize gene pools. Crop Sci. 1989, 29, 12–17.

    Article  Google Scholar 

  • Desjardins, A. E.; Plattner, R. D.; Nelson, P. E. Fumonisin production and other traits of Fusarium moniliforme strains from maize in northeast Mexico. Appl. Environ. Microbiol. 1994, 60, 1695–1697.

    CAS  Google Scholar 

  • Dowd, P. F. Toxicological and biochemical interactions of the fungal metabolites fusaric acid and kojic acid with xenobiotics in Heliothis zea (F) and Spodoptera frugiperda (J.E. Smith). Pestic. Biochem. Physiol. 1988, 32, 123–134.

    Article  CAS  Google Scholar 

  • Ehrlich, M. A.; Ehrlich, H. G. Fine structure of the host-parasite interfaces in mycoparasitism. Ann. Rev. Phytopathol. 1971, 9, 155–184.

    Article  Google Scholar 

  • Fisher, K. D. Hydrolytic enzyme and toxin production by sweet potato fusaria. Phytopathology 1965, 55, 396–398.

    CAS  Google Scholar 

  • Foley, D. C. Systemic infection of corn by Fusarium moniliforme. Phytopathology 1962, 52, 870–872.

    Google Scholar 

  • Galum, M.; Paran, N.; Ben-Shaul, Y. Structural modifications of the phycobiont in the lichen thallus. Protoplasma 1970, 69, 85–96.

    Article  Google Scholar 

  • Gaumann, E. Fusaric acid as a wilt toxin. Phytopathology 1957, 47, 342–357.

    Google Scholar 

  • Hadley, G.; Johnson, R. P.; John, D. A. Fine structure of the host-fungus interface in orchid mycorrhiza. Planta 1971, 100, 191–199.

    Article  Google Scholar 

  • Heath, M. C. Ultrastructure of host and nonhost reactions to cowpea rust. Phytopathology 1972, 62, 27–38.

    Article  Google Scholar 

  • Headrick, J. M.; Pataky, J. K. Resistance to kernel infection by Fusarium moniliforme in inbred lines of sweet corn and the effect of infection on emergence. Plant Dis. 1989. 73; 882–892.

    Article  Google Scholar 

  • Heitefuss, R.; Stahmann, M. A.; Walker, J. C. Production of pectolytic enzymes and fusaric acid by Fusarium oxysporum F. sp. conglutinans in relation to cabbage yellows. Phytopathology 1960, 50, 367–370.

    CAS  Google Scholar 

  • Hidaka, H.; Nagatsu, T.; Takeya, K. Fusaric acid, a hypotensive agent produced by fungi. J. Antibiot. 1969, 22, 228–230.

    Article  CAS  Google Scholar 

  • Hinton, D.M; Bacon, C. W. The distribution and ultrastructure of the endophyte of toxic tall fescue. Can. J. Bot. 1985, 63, 36–42.

    Article  Google Scholar 

  • Jacobs, J. B.; Ahmadjian, V. The ultrastructure of lichens. I. A general survey. J. Phycol. 1969; 5, 227–240.

    Article  CAS  Google Scholar 

  • Kedera, C. J.; Leslie, J. F.; Claflin, L. E. Genetic diversity of Fusarium section Liseola (Gibberella fujikuroi) in individual maize stalks. Phytopathology 1994; 84; 603–607.

    Article  Google Scholar 

  • King, S. B.; Scott, G. E. Genotypic differences in maize to kernel infection by Fusarium moniliforme. Phytopathology 1981, 71, 1245–1247.

    Article  Google Scholar 

  • Klittich, C. J.; Leslie, J. F. Identification of a second mating population within the Fusarium moniliformeanamorph of Gibberella fujikuroi. Mycologia 1992, 84, 541–547

    Article  Google Scholar 

  • Kommedahl, T.; Windeis, C. E. Root-, stalk-, and ear-infecting Fusarium species on corn in the USA. In Fusarium: Diseases, Biology and Taxonomy, Nelson, P. E.; Toussoun, T. A.; Cook, R. J., Eds.; The Pennsylvania State University Press: University Park, 1981; pp 94–103.

    Google Scholar 

  • Kuo, M. S.; Scheffer, R. P. Evaluation of fusaric acid as a factor in development of Fusarium wilt. Phytopathology 1964, 54, 1041–1044.

    CAS  Google Scholar 

  • Leslie, J. F. Mating populations in Gibberella fujikuroi (Fusarium section Liseola). Phytopathology 1991, 81, 1058–1060.

    Google Scholar 

  • Leslie, J. F.; Doe, F. J.; Plattner, R. D.; Shackelford, D. D.; Jonz, J. Fumonisin Bj production and vegetative compatibility of strains from Gibberella fujikuroi mating population ‘A’ (Fusarium moniliforme). Mycopathologia 1992, 117, 37–45.

    Article  CAS  Google Scholar 

  • Liddell, C. M.; Burgess, L. W. Survival of Fusarium moniliforme at controlled temperature and relative humidity. Trans. Br. Mycol. Soc. 1985, 84, 121–130.

    Article  Google Scholar 

  • Marasas, W. F. O.; Nelson, P. E.; Toussoun, T. A. Toxigenic Fusarium Species; The Pennsylvania State University Press: University Park, 1984.

    Google Scholar 

  • Molot, P. M.; Simone, J. Technique de contamination artificielle des semences de mais par les Fusarioses. Rev. Zoo. Agricole Appl. 1967, 3, 29–32.

    Google Scholar 

  • Niemeyer, H. M. Hydroxamic acids (4-hydro-l, 4-benzozazin-3-ones), defense chemical in the Gramineae. Phytochemistry 1988, 27, 3349–3358.

    Article  CAS  Google Scholar 

  • Norred, W. P.; Wang, E.; Yoo, H.; Riley, R. T.; Merrill, A. H., Jr. In vitro toxicology of fumonisins and the mechanistic implications. Mycopathologia 1992, 117, 73–78.

    Article  CAS  Google Scholar 

  • Nyvall, R. F.; Kommedahl, T. Individual thickened hyphae as survival structures of Fusarium moniliforme in corn. Phytopathology 1968, 58, 1704–1707.

    Google Scholar 

  • Nyvall, R. F.; Kommedahl, T. Saprophytism and survival of Fusarium moniliforme in corn stalks. Phytopathology 1970, 60, 1233–1235.

    Article  Google Scholar 

  • Ochor, T. E.; Trevatham, L. E.; King, S. B. Relationship of harvest date and host genotype to infection of maize kernels by Fusarium moniliforme. Plant Dis. 1987, 71, 311–313.

    Article  Google Scholar 

  • Ooka, J.J; Kommedahl, T. Wind and rain dispersal of Fusarium moniliforme in corn fields. Phytopathology 1977, 67, 1233–1235.

    Google Scholar 

  • Paterson, R. R. M.; Rutherford, M. A. A simplified rapid technique for fusaric acid detection in Fusarium strains. Mycopathologia 1991, 113, 171–173.

    Article  CAS  Google Scholar 

  • Pennypacker, B. W. Anatomical changes involved in the pathogenesis of plants by Fusarium. In Fusarium: Diseases, biology, and taxonomy; Nelson, P. E.; Toussoun, T. A.; Cook, R. J., Ed.; Pennsylvania State University Press: University Park, 1981; pp 400–408.

    Google Scholar 

  • Petersen, W.; Böttger, M. Contribution of organic acids to the acidification of the rhizosphere of maize seedlings. Plant Soil 1991, 132, 159–163.

    CAS  Google Scholar 

  • Pitel, D. W.; Vining, L. C. Accumulation of dehydrofusaric acid and its conversion to fusaric and 10-hydroxy-fusaric acids in cultures of Gibberella fujikuroi. Can. J. Biochem. 1970, 48, 623–630.

    Article  CAS  Google Scholar 

  • Plattner, R. D.; Nelson, P. E. Production of beauvericin by a strain of Fusarium proliferatum isolated from corn fodder for swine. Appl. Environ. Microbiol. 1994, 60, 3894–3896.

    CAS  Google Scholar 

  • Porter, J. K.; Bacon, C. W. Fusaric acid, a toxin produced by Fusarium moniliforme: Effects on brain and pineal neurotransmitters and metabolites in rats. Proc.6th Collog. Eur. Pineal Soc. 1993, June 23–27, E19. (Abstract)

    Google Scholar 

  • Richard, J. L.; Bennett, G. A.; Ross, P. F.; Nelson, P. E. Analysis of naturally occurring mycotoxins in feedstuffs and food. J. Anim. Sci. 1993, 71, 2563–2574.

    CAS  Google Scholar 

  • Richardson, M. D.; Bacon, C. W. Cyclic hydroxamic acid accumulation in corn seedlings exposed to reduced water potentials before, during, and after germination. J. Chem. Ecol. 1993, 8, 1613–1624.

    Article  Google Scholar 

  • Richardson, M. D.; Bacon, C. W. Catabolism of 6-methoxy-benzoxazolinone and 2-benzoxazolinone. Mycologia 1995, 87, 510–517.

    Article  CAS  Google Scholar 

  • Riley, R. T.; Norred, W. P.; Bacon, C. W. Fungal toxins in foods: Recent concerns. Annu. Rev. Nutr. 1993, 13, 167–189.

    Article  CAS  Google Scholar 

  • Shurtleff, M. C. Compendium of Corn Diseases, 2nd ed.; The American Phytopathological Society: St. Paul, MN, 1980.

    Google Scholar 

  • Stoll, C.; Renz, J. Uber den Fusarinsaure-und dehydrofusarinsaure-stoffwechsel von Gibberella fujikuroi. Phytopath. Z. 1957, 29, 380–387

    CAS  Google Scholar 

  • Styer, R. C.; Cantliffe, D. J. Relationship between environment during seed development and seed vigor of two endosperm mutants of corn. J. Amer. Soc. Hort. Sci. 1983. 108, 717–720.

    Google Scholar 

  • Sydenham, E. W.; Shephard, G. S.; Thiel, P. G.; Marasas, W. F. O. Stockenström, S. Fumonisin contamination of commercial corn-based human foodstuffs. J. Agric. Food Chem. 1991, 39, 2014–2018.

    Article  CAS  Google Scholar 

  • Tamari, K.; Kaji, J. Studies on the mechanism of the growth inhibitory action of fusarinic acid on plants. J. Bact. 1954, 41, 143–165.

    CAS  Google Scholar 

  • Thiel, P. G.; Shephard, G. S.; Sydenham, E. W.; Marasas, W. F. O.; Nelson, P. E.; Wilson, T. M. Levels of fumonisins B1 and B2 in feeds associated with confirmed cases of equine leukoencephalomalacia. J. Agric. Food Chem. 1991, 39, 109–111.

    Article  CAS  Google Scholar 

  • Thomas, M. D.; Buddenhagen, I. W. Incidence and persistence of Fusarium moniliforme in symptomless maize kernels and seedlings in Nigeria. Mycologia 1980, 72, 882–887.

    Article  Google Scholar 

  • Van Etten, H. D.; Matthews, D. E.; Matthews, P. S. Phytoalexin detoxification: importance for pathogenicity and practical implications. Ann. Rev. Phytopathol. 1989, 27, 143–164.

    Article  Google Scholar 

  • Vesonder, R. F.; Hesseltine, C. W. Metabolites of Fusarium. In Fusarium: Diseases, Biology and Taxonomy; Nelson, P.E.; Toussoun, T.A. Cook, R.J., Eds.; The Pennsylvania State University Press: University Park, 1981; pp 350–364.

    Google Scholar 

  • Wahlroos, O.; Virtanen, A. I. On the antifungal effect of benzoxazolinone and 6-methoxybenzoxazolinone, respectively on Fusarium nivale. Acta Chem. Scand. 1958, 12, 124–128

    Article  CAS  Google Scholar 

  • Whitney, N. J.; Mortimore, C. G. An antifungal substance in the corn plant and its effect on growth of two stalk-rotting fungi. Nature 1959, 183, 341.

    Article  CAS  Google Scholar 

  • Wiebe, L. A.; Bjeldanes, L. F. Fusarin C, a mutagen from Fusarium moniliforme. J. Food Sci 1981, 46, 1424–1426.

    Article  CAS  Google Scholar 

  • Woodward, M. D.; Corcuera, L. J.; Helgeson, J. P.; Upper, C. D. Decomposition of 2, 4-dihydroxy-7-methoxy-2H-l, 4-benzoxazin-3(3H)-one in aqueous solution. Plant Physiol. 1978, 61, 796–802.

    Article  CAS  Google Scholar 

  • Xie, Y. S.; Arnason, J. T.; Philogène, B. J. R.; Atkinson, J.; Morand, P. Distribution and variation of hydroxamic acids and related compounds in maize (Zea mays) root system. Can. J. Bot. 1991, 69, 677–681.

    Article  CAS  Google Scholar 

  • Yabuta, T.; Kambe, K.; Hayashi, T. Biochemistry of the bakanae-fungus. I. Fusarinic acid, a new product of the bakanae fungus. J. Agr. Chem. Soc. Japan 1937, 10, 1059–1068.

    Google Scholar 

  • Yan, K.; Dickman, M. B.; Xu, J.-R.; Leslie, J. F. Sensitivity of field strains of Gibberella fujikuroi (Fusarium section Liseola) to benomyl and hygromycin B. Mycologia, 1993, 85, 206–213.

    Article  CAS  Google Scholar 

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  1. Toxicology and Mycotoxin Research Unit, Russell Research Center, USDA, ARS, P.O. Box 5677, Athens, Georgia, 30604-5677, USA

    C. W. Bacon & D. M. Hinton

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  1. C. W. Bacon
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Editors and Affiliations

  1. Food and Drug Administration, National Center for Food Safety and Technology, Summit-Argo, Illinois, USA

    Lauren S. Jackson

  2. General Mills, Inc., Minneapolis, Minnesota, USA

    Jonathan W. DeVries

  3. University of Nebraska-Lincoln, Lincoln, Nebraska, USA

    Lloyd B. Bullerman

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Bacon, C.W., Hinton, D.M. (1996). Fusaric Acid and Pathogenic Interactions of Corn and Non-Corn Isolates of Fusarium moniliforme, a Nonobligate Pathogen of Corn. In: Jackson, L.S., DeVries, J.W., Bullerman, L.B. (eds) Fumonisins in Food. Advances in Experimental medicine and Biology, vol 392. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1379-1_16

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  • DOI: https://doi.org/10.1007/978-1-4899-1379-1_16

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