Skip to main content
SpringerLink
Log in

Identification of AT1 Receptors on Cultured Astrocytes

  • Chapter
Recent Advances in Cellular and Molecular Aspects of Angiotensin Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 396))

Abstract

It is well established that the brain contains an endogenous renin-angiotensin system (RAS) that participates in the regulation of blood pressure through the control of water intake and sodium appetite, the secretion of ACTH and Vasopressin and the regulation of sympathetic tone (1). While high affinity binding sites for Ang II were initially characterized in brain homogenates (2, 3), the technique of in vitro receptor autoradiography allowed visualization of Ang II binding sites to specific brain regions including the circumventricular organs, hypothalamus, dorsal and ventral medulla, spinal cord and pituitary gland (1, 4, 5). These brain regions correspond to areas at which the peptide exerts its physiological effects (5) or where the responses are inhibited by Ang II receptor antagonists (6).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ferrario, C.M., Ueno, Y., Diz, D.I. and Barnes, K.L. (1986) in Handbook of Hypertension, Vol.8: Pathophysiology of Hypertension— Regulatory Mechanisms, (eds. A. Zanchetti and R.C. Tarazi), Elsevier Science Publishers B.V. pp 431-54

    Google Scholar 

  2. Simonnet, G. and Vincent, J.D. (1982) Neurochem. Int. 4: 149–55

    Article  PubMed  CAS  Google Scholar 

  3. Bennett, J.P. and Snyder, S.H. (1976) J. Biol. Chem. 251: 7423–30

    PubMed  CAS  Google Scholar 

  4. Speth, R.C., Wamsley, J.K., Gehlert, D.R., Chernicky, C.L., Barnes, K.L. and Ferrario, C.M. (1985) Brain Res. 326: 137–43

    Article  PubMed  CAS  Google Scholar 

  5. Brosnihan, K.B., Diz, D.I., Schiavone, M.T., Averill, D.B. and Ferrario, C.M. (1987) in Brain Peptides and Catecholamines in Cardiovascular Regulation (eds. J.P. Buckley and C.M. Ferrario), Raven Press, New York: pp 313–28

    Google Scholar 

  6. Campagnole-Santos, M.J., Diz, D.I., Santos, R.A., Khosla, M.C., Brosnihan, K.B. and Ferrario, C.M. (1988) Hypertension 11 (Supp 1): I–167–71

    Google Scholar 

  7. Tallant, E.A., Diz, D.I., Khosla, M.C. and Ferrario, C.M. (1991) Hypertension 17: 1135–43

    Article  PubMed  CAS  Google Scholar 

  8. Fluharty, S.J. and Reagan, L.P. (1989) J. Neurochem. 52: 1393–400

    Article  PubMed  CAS  Google Scholar 

  9. Raizada, R.K., Phillips, M.I., Crews, F.T. and Sumners, C. (1987) Proc. Natl. Acad. Sci. USA 84: 4655–9

    Article  PubMed  CAS  Google Scholar 

  10. Jaiswal, N., Diz, D.I., Tallant, E.A., Khosla, M.C. and Ferrario, C.M. (1991) Am. J. Physiol. Regul. Integr. Comp. Physiol. 260: R1000–6

    CAS  Google Scholar 

  11. Jaiswal, N., Tallant, E.A., Diz, D.I., Khosla, M.C. and Ferrario, C.M. (1991) Hypertension 17: 1115–20

    Article  PubMed  CAS  Google Scholar 

  12. Speth, R.C. and Harik, S.I. (1985) Proc. Natl. Acad. Sci. USA 82: 6340–3

    Article  PubMed  CAS  Google Scholar 

  13. Guillot, F.L. and Audus, K.L. (1991) Peptides 12: 535–40

    Article  PubMed  CAS  Google Scholar 

  14. Thomas, W.G., Greenland, K.J., Shinkel, T.A. and Sernia, C. (1992) Brain Res. 588: 191–200

    Article  PubMed  CAS  Google Scholar 

  15. Milsted, A., Barna, B.P., Ransohoff, R.M., Brosnihan, K.B. and Ferrario, C.M. (1990) Proc. Natl. Acad. Sci. USA 87: 5720–3

    Article  PubMed  CAS  Google Scholar 

  16. Deschepper, C.F., Bouhnik, J. and Ganong, W.F. (1986) Brain Res. 374: 195–8

    Article  PubMed  CAS  Google Scholar 

  17. Stornetta, R.L., Hawelu-Johnson, C.L., Guyenet, P.G. and Lynch, K.R. (1988) Science 242: 1444–6

    Article  PubMed  CAS  Google Scholar 

  18. Gyurko, R., Wielbo, D. and Phillips, M.I. (1993) Regul. Pept. 49: 167–74

    Article  PubMed  CAS  Google Scholar 

  19. Printz, M.P., Jennings, C., Healy, D.P. and Kalter, V. (1986) J. Cardiovasc. Pharmacol. 8(Suppl 10): S62–8

    Article  PubMed  CAS  Google Scholar 

  20. Hosli, E. and Hosli, L. (1989) Neuroscience 31: 463–70

    Article  PubMed  CAS  Google Scholar 

  21. Bottari, S.P., Obermüller, N., Bogdal, Y., Zahs, K.R. and Deschepper, C.F. (1992) Brain Res. 585: 372–6

    Article  PubMed  CAS  Google Scholar 

  22. Barna, B.P., Chou, S.M., Jacobs, B., Ransohoff, R.M., Hahn, J.F. and Bay, J.W. (1985) J. Neuroimmunol. 10: 151–8

    Article  PubMed  CAS  Google Scholar 

  23. Estes, M.L., Ransohoff, R.M., McMahon, J.T., Jacobs, B.S. and Barna, B.P. (1991) J. Neurosci. Res. 27: 697–705

    Article  Google Scholar 

  24. Smith, J.B. (1986) Am. J. Physiol. 250: F759–69

    PubMed  CAS  Google Scholar 

  25. Campanile, C.P., Crane, J.K., Peach, M.J. and Garrison, J.C. (1982) J. Biol. Chem. 257: 4951–8

    PubMed  CAS  Google Scholar 

  26. Johnson, R.M. and Garrison, J.C. (1987) J. Biol. Chem. 262: 17285–93

    PubMed  CAS  Google Scholar 

  27. Tallant, E.A., Jaiswal, N., Diz, D.I. and Ferrario, C.M. (1991) Hypertension 18: 32–9

    Article  PubMed  CAS  Google Scholar 

  28. Jaiswal, N., Diz, D.I., Tallant, E.A., Khosla, M.C. and Ferrario, C.M. (1991) Am. J. Hypertens. 4: 228–33

    Article  PubMed  CAS  Google Scholar 

  29. Cole, R. and de Vellis, J. (1989). in A Dissection and Tissue Culture Manual of the Nervous System (eds. A. Shahar, J. de Vellis, A. Vernadakis and B. Haber), Alan R. Liss, Inc. New York: pp 121–33

    Google Scholar 

  30. Berridge, M.J. (1983) Biochem. J. 212: 849–58

    PubMed  CAS  Google Scholar 

  31. Sumners, C., Tang, W., Zelezna, B. and Raizada, M.K. (1991) Proc. Natl. Acad. Sci. USA 88: 7561–11

    Article  Google Scholar 

  32. Sumners, C., Meyers, L.M., Kalberg, C.J. and Raizada, M.K. (1990) Prog. Neurobiol. 34: 355–85

    Article  PubMed  CAS  Google Scholar 

  33. Tsutsumi, K. and Saavedra, J.M. (1991) Am. J. Physiol. Regul. Integr. Comp. Physiol. 261: R209–16

    CAS  Google Scholar 

  34. Khayyall, M., MacGregor, J., Brown, J.J., Lever, A.F. and Robertson, J.I.S. (1973) Clin. Sci. 44: 87–90

    PubMed  CAS  Google Scholar 

  35. Kohara, K., Brosnihan, K.B., Ferrario, C.M. and Milsted, A. (1992) Am. J. Physiol. 262: E651–7

    PubMed  CAS  Google Scholar 

  36. Nishimura, M., Milsted, A., Block, C.H., Brosnihan, K.B. and, Ferrario, C.M. (1992) Hypertension 20: 158–67

    Article  PubMed  CAS  Google Scholar 

  37. Chiu, E.K. and Richardson, J.S. (1983) J. Gen. Pharmacol. 14: 553–63

    Article  CAS  Google Scholar 

  38. Brooks, D.P., Share, L. and Crofton, J.T. (1986) Endocrinology 118: 1716–22

    Article  PubMed  CAS  Google Scholar 

  39. Inoui, M., Crofton, J.T., Toba, K. and Share, L. (1990). FASEB J. 4: A683

    Google Scholar 

  40. White, R.P. and Hagen, A.A. (1982) Pharmacol. Ther. 18: 313–31

    Article  PubMed  CAS  Google Scholar 

  41. Wahl, A., Unterberg, A., Baethmann, A. and Schilling, L. (1988) J. Cereb. Blood Flow Metab. 8: 621–34

    Article  PubMed  CAS  Google Scholar 

  42. Palmer, G.C. (1986) Neurosci. Biobehav. Rev. 10: 79–101

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hypertension Center, Bowman Gray School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina, 27157-1032, USA

    E. Ann Tallant, Debra I. Diz & Carlos M. Ferrario

Authors
  1. E. Ann Tallant
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Debra I. Diz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carlos M. Ferrario
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada , M. Ian Phillips  & Colin Sumners ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Tallant, E.A., Diz, D.I., Ferrario, C.M. (1996). Identification of AT1 Receptors on Cultured Astrocytes. In: Raizada, M.K., Phillips, M.I., Sumners, C. (eds) Recent Advances in Cellular and Molecular Aspects of Angiotensin Receptors. Advances in Experimental Medicine and Biology, vol 396. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1376-0_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-1376-0_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1378-4

  • Online ISBN: 978-1-4899-1376-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation